|IMGT unique numbering|
|IMGT label for conserved AA||AA and IMGT numbering||IMGT label for regions||IMGT label for FR and CDR||Old VH Numbering #1|
|R106 (or K106)||3'V-REGION||CDR3-IMGT||R94 (or K94)|
Among the interactions between AA of the VH CDR3-IMGT: salt bridge between R106 (or K106) and D116 in the CDR3-IMGT.
Among the interactions between AA of the VH FR3-IMGTand FR4-IMGT: hydrogen bond between C104 (FR3-IMGT) and G119 (FR4-IMGT).
The genomic coordinates of the whole Homo sapiens IGH locus in GRCh38.p2 are:
106.879.844 (5' end of the locus, telomeric, 5' end of IGHV(III)-82)
105.584.157 (3' end of the locus, centromeric, 3' end of IGHA2).
(1296 kb in the current assembly)
You can query 'LOCALIZATION in GENOME ASSEMBLIES' at the bottom of the 'IMGT/GENE-DB Query page' (just click on 'Submit' as the 'Homo sapiens IGH' is searched by default), for retrieving gene localization in the genome assembly.
You can modify these coordinates if you would like to encompass more sequence in 5' or 3' of the locus (for ex 5 kb on each side)
106.879.844 + 5.000
105.584.157 - 5.000