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Correspondence between V numberings

Correspondence between numberings for CDR of different lengths (horizontal display)

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CDR2-IMGT

This table displays the correspondence between the IMGT unique Lefranc numbering [1], Kabat [2] and Chothia [3-5] numberings for CDR2 of different lengths, with gaps indicated by dashes. For a table showing the same CDR2 amino acid numberings but without gaps, and therefore without correspondence, click here.

Asterisks indicate positions for which it is not possible to make changes from one numbering to the other, automatically [1].
Brackets indicate the limits of the CDR in each numbering.

Click on the protein name for the CDR2-IMGT 3D structure.
For more information on the proteins, see Protein with known 3D structures Identification and Colliers de Perles: Human Immunoglobulins


IMGT               FR2-IMGT              CDR2-IMGT                            FR3-IMGT 
unique
numbering [1]          55 [56  57  58  59  60  61  62  63  64  65] 66  67  68  69  70  71  72  73  74                     CDR       CDR2-
                                                                                                                        length[2]  IMGT[1]
                                    *   *   *  *   *   *   *   *
IGHV [2]              [50  51  52  52A 52B 52C 53  54  55  56  57  58  59  60  61  62  63  64   -  65]                     19        10 
and VH                [50  51  52  52A 52B  -  53  54  55  56  57  58  59  60  61  62  63  64   -  65]                     18         9 
                      [50  51  52  52A  -   -  53  54  55  56  57  58  59  60  61  62  63  64   -  65]                     17         8
                      [50  51  52   -   -   -  53  54  55  56  57  58  59  60  61  62  63  64   -  65]                     16         7 

                                                                                                          H2 "canonical    H2       CDR2-      Example
                                                                                                            structure"   length[5] IMGT[1]   of proteins
                                    *   *   *  *   *   *   *   *
IGHV [3-5]             50  51  52 [52a 52b 52c 53  54  55] 56  57  58  59  60  61  62  63  64   -  65           4           6         10      McPC603,4-4-20
and VH                 50  51  52 [52a 52b  -  53  54  55] 56  57  58  59  60  61  62  63  64   -  65           -           5          9 
                       50  51  52 [52a  -   -  53  54  55] 56  57  58  59  60  61  62  63  64   -  65           2,3         4          8       Kol, J539
                       50  51  52 [ -   -   -  53  54  55] 56  57  58  59  60  61  62  63  64   -  65           1           3          7       Newm






IMGT               FR2-IMGT            CDR2-IMGT                            FR3-IMGT 
unique
numbering [1]         55 [56  57  58  59  60  61  62  63  64  65] 66  67  68  69  70  71  72  73  74                      CDR       CDR2-
                                                                                                                        length[2]  IMGT[1]
                                   *   *   *   *   *   *   *   *
IGKV [2]              49 [50  51  52   -   -   -   -   -   -   -  53  54  55  56] 57  58  59   -  60                       7          3 
and V-KAPPA
                                                                                                          L2 "canonical    L2       CDR2-     Example
                                                                                                            structure"   length[5] IMGT[1]  of proteins
                                   *   *   *   *   *   *   *   *
IGKV [3-5]            49 [50  51  52]  -   -   -   -   -   -   -  53  54  55  56  57  58  59   -  60            1          3          3       Rei, McPC603,                                                                                                                                             J539
and V-KAPPA




IMGT               FR2-IMGT            CDR2-IMGT                            FR3-IMGT
unique                                                                                       
numbering [1]         55 [56  57  58  59  60  61  62  63  64  65] 66  67  68  69  70  71  72  73  74                       CDR       CDR2-
                                                                                                                         length[2]  IMGT[1]
                                   *   *   *   *   *   *   *   *
IGLV [2]              49 [50  51  52   -   -   -   -   -   -   -  53  54  55  56] 57  58  59   -  60                       7          3
and V-LAMBDA
                                                                                                          L2 "canonical    L2        CDR2-     Example
                                                                                                            structure"   length[5]  IMGT[1]  of proteins
                                   *   *   *   *   *   *   *   *
IGLV [3-5]            49 [50  51  52]  -   -   -   -   -   -   -  53  54  55  56  57  58  59   -  60            1          3          3       Kol, Rhe
and V-LAMBDA
References:
[1] Lefranc, M.-P., The Immunologist, 7, 132-136 (1999).
[2] Kabat, E.A. et al., In: Sequences of Proteins of Immunological Interest, NIH Publication, 91-3242 (1991).
[3] Chothia, C. and Lesk, A.M., J. Mol. Biol., 196, 901-917 (1987).
[4] Chothia, C. et al., Nature, 342, 877-883 (1989).
[5] Al-Lazikani, B. et al., J. Mol. Biol., 273, 927-948 (1997).