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List of standardized IMGT/LIGM-DB keywords

Use the following keywords as far as possible to describe your sequences when you submit them to a generalist database (EMBL-Bank, GenBank, DDBJ).

ChainType

The chain type identifies the nature of the peptidic chain potentially encoded by IG, TR, MH and RPI genes.

ConfigurationType

FormatType

Functionality

GeneType

Four types of genes are involved in the IG and TR synthesis: the variable (V), diversity (D) and joining (J) genes which encode the part of the IG and TR chain, or variable domain, that binds the antigens (recognition function), and the constant (C) genes which encode the part of the IG or TR chain, or C region, which has effector properties in IG.

General

HealthStatus

IMGT_Expertise

LocationType

MolecularComponent

MoleculeType

Molecule_EntityType

Obtention

Particularities

Recombinaison

Regulation

StructureType

The structure type distinguishes sequences that show a classical organisation (regular), from those which have been modified either naturally (spliced, processed...), or artificially (humanized, engineered...).

TaxonomyRelated

  • chimeric
    Identifies, whatever the molecule type, the sequences that have a classical organization and result from the fusion in vivo or in vitro of molecules from two (usually) sources. For example, L-V-D-J-C-sequence of IG resulting from the fusion in vitro of the variable domain from one source (murine, rat...) with the constant region from human [2 sources].
  • humanized
    Identifies, whatever the molecule type, the sequences that have a classical organization and have been modified in vitro with the purpose of humanization. For example, L-V-D-J-C-sequence of IG resulting from the grafting in vitro of the CDR from one source (murine, rat...) to the FR (and with the constant region) from human [2 sources].
  • synthetic construct
    Identifies sequences which cannot be assigned to a taxon (Taxonomy), or to chimeric or humanized.