Homo sapiens IGHG1 amino acids involved in the interactions with the C1q, FcγR and FCGRT

1. Structural and biological properties of human immunoglobulins

2. Human immunoglobulin (IG) chain characteristics

3. IG interchain disulfide bridges per monomer

4. Lysines and cysteines of the Homo sapiens IGHG1, IGKC and IGLC1 and positions in the C-DOMAIN

5. Amino acid positions involved in ADCC, CDC, half life and half-IG exchange

6. IMGT engineered variant nomenclature: IGHG variants

The IMGT unique numbering is shown, for the Homo sapiens IGHG1 CH2 and CH3 domains involved in the interactions with the C1q, FcγR and FCGRT.

The IGHG1 amino acid sequence is the translation of J00228 (IGHG1*01). Correspondence is shown with the Eu numbering. For correspondence for the complete IGHG1 sequence, see Correspondence between the IMGT unique numbering for C-DOMAIN, the IMGT exon numbering, the Eu and Kabat numberings: Human IGHG.

AA and positions highlighted in this table are those from ‘Amino acid positions involved in ADCC, ADCP, CDC, half-life and half-IG exchange’, quoted for their interaction with the FcγR (yellow) or with the FGRT (FcRn) (orange). IGHG1 AA and positons important for the C1q binding [1, 2, 3, 4] are shown with a green background.

Strands, turns and loops for C-DOMAIN IMGT unique numbering for C-DOMAIN CH2 Strands, turns and loops for C-DOMAIN IMGT unique numbering for C-DOMAIN CH3
IGHG1 Eu numbering IGHG1 Eu numbering
1.6 (A) 231 - - -
1.5 P 232 - - -
1.4 E 233 1.4 (G) -
1.3 L 234 1.3 Q -
1.2 L 235 1.2 P 343
1.1 G 236 1.1 R 344
A-STRAND 1 G 237 A-STRAND 1 E 345
2 P 238 2 P 346
3 S 239 3 Q 347
4 V 240 4 V 348
5 F 241 5 Y 349
6 L 242 6 T 350
7 F 243 7 L 351
8 P 244 8 P 352
9 P 245 9 P 353
10 K 246 10 S 354
11 P 247 11 R 355
12 K 248 12 D 356
13 D 249 13 E 357
14 T 250 14 L 358
15 L 251 15 T 359
AB-TURN 15.1 M 252 AB-TURN 15.1 - -
15.2 I 253 15.2 - -
15.3 - - 15.3 - -
B-STRAND 16 S 254 B-STRAND 16 K 360
17 R 255 17 N 361
18 T 256 18 Q 362
19 P 257 19 V 363
20 E 258 20 S 364
21 V 259 21 L 365
22 T 260 22 T 366
23 C 261 23 C 367
24 V 262 24 L 368
25 V 263 25 V 369
26 V 264 26 K 370
BC-LOOP 27 D 265 BC-LOOP 27 G 371
28 V 266 28 F 372
29 S 267 29 Y 373
30 H 268 30 P 374
31 E 269 31 - -
34 D 270 34 - -
35 P 271 35 S 375
36 E 272 36 D 376
37 V 273 37 I 377
38 K 274 38 A 378
C-STRAND 39 F 275 C-STRAND 39 V 379
40 N 276 40 E 380
41 W 277 41 W 381
42 Y 278 42 E 382
43 V 279 43 S 383
44 D 280 44 N 384
45 G 281 45 G 385
CD-STRAND 45.1 V 282 CD-STRAND 45.1 Q 386
45.2 E 283 45.2 P 387
45.3 V 284 45.3 E 388
45.4 H 285 45.4 N 389
D-STRAND 77 N 286 D-STRAND 77 N 390
78 A 287 78 Y 391
79 K 288 79 K 392
80 T 289 80 T 393
81 K 290 81 T 394
82 P 291 82 P 395
83 R 292 83 P 396
84 E 293 84 V 397
DE-TURN 84.1 E 294 DE-TURN 84.1 V 398
84.2 Q 295 84.2 L 399
84.3 Y 296 84.3 D 400
84.4 N 297 84.4 S 401
85.4 S 298 85.4 D 402
85.3 T 299 85.3 G 403
85.2 Y 300 85.2 S 404
85.1 R 301 85.1 F 405
E-STRAND 85 V 302 E-STRAND 85 L 406
86 V 303 86 Y 407
87 S 304 87 S 408
88 V 305 88 K 409
89 L 306 89 L 410
90 T 307 90 T 411
91 V 308 91 V 412
92 L 309 92 D 413
93 H 310 93 K 414
94 Q 311 94 S 415
95 D 312 95 R 416
96 W 313 96 W 417
F-STRAND 97 L 314 F-STRAND 97 Q 418
98 N 315 98 Q 419
99 G 316 99 G 420
100 K 317 100 N 421
101 E 318 101 V 422
102 Y 319 102 F 423
103 K 320 103 S 424
104 C 321 104 C 425
FG-LOOP 105 K 322 FG-LOOP 105 S 426
106 V 323 106 V 427
107 S 324 107 M 428
108 N 325 108 H 429
109 K 326 109 E 430
110 A 327 110 A 431
111 - - 111 - -
112 - - 112 L 432
113 L 328 113 H 433
114 P 329 114 N 434
115 A 330 115 H 435
116 P 331 116 Y 436
117 I 332 117 T 437
G-STRAND 118 E 333 G-STRAND 118 Q 438
119 K 334 119 K 439
120 T 335 120 S 440
121 I 336 121 L 441
122 S 337 122 S 442
123 K 338 123 L 443
124 A 339 124 S 444
125 K 340 125 P 445
- - - CHS 1 G 446
- - - CHS 2 K 447
References:
  1. [1] Tao M.H. et al., J Exp Med, 178(2):661-7 (1993). PMID: 8340761
  2. [2] Brekke O.H. et al., Eur J Immunol, 24(10):2542-7 (1994). PMID: 7925582
  3. [3] Idusogie E.E. et al., J. Immunol, 164(8):4178-84 (2000). PMID: 10754313
  4. [4] Morgan A. et al., Immunology, 86(2):319-24 (1995). PMID: 7490135

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