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Nomenclature and overview of the human immunoglobulin genes

Editors: Marie-Paule Lefranc and Gérard Lefranc (Université Montpellier 2, CNRS, Montpellier, France).

TO CONSULT:

How many IGH, IGK, IGL genes in the human genome? Where are they localized?

What is the organization of the human IGH, IGK and IGL loci?

How many functional IG genes? What is the expressed IG repertoire?

How to make 107 Ig-Heavy, 4.104 Ig-Lambda and 6.104 Ig-Kappa chains? (1012 different antibodies)

What is the structure of an immunoglobulin and its different chains?

Are all the human IG genes known ? How to analyse the expressed variable IG genes?

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Created:
11/06/2001
Last updated:
25/04/2012
Authors:
Elodie Foulquier and Marie-Paule Lefranc
Editor:
Chantal Ginestoux