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Spacefill 3D representation of an IgG immunoglobulin

VH corresponds to the V-D-J-REGION (in green (V), orange (DJ)) of the heavy chain.
VL corresponds to the V-J-REGION (in green (V) and yellow (J)) of the light chain.
Click here for a Schematic representation of an immunoglobulin.

The corresponding PDB (Protein Data Bank) format file is from Mike's immunoglobulin structure function site (http://www.umass.edu/microbio/rasmol/padlan.htm).

The first chrystal 3D structure of a complete immunoglobulin is that of B12, a human IgG1, anti-HIV1, determined in 2001 (PDB code: 1hzh in IMGT/3Dstructure-DB).

This IgG1 model is described in Fig. 1 in Anatomy of the Antibody Molecule by Eduardo A. Padlan, Mol. Immunol. 31:169-217, 1994.
It is a composite model of a F(ab')2 built from the Fab from 2ig2 and an Fc fragment from 1fc2. Part of the hinge region and other details are theoretically modeled.


Created: 28/06/2001
Last updated: Wednesday, 29-Jun-2011 17:01:44 CEST
Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Editors: Elodie Foulquier, Chantal Ginestoux

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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