| Print of this table: Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, London, UK (458 pages), 2001, ISBN:012441351X |
Chain characteristics |
Chain types |
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| Heavy chain | Light chain | |||||||||||
| μ | δ | γ1 | γ2 | γ3 | γ4 | α1 | α2 | ε | κ | λ | ||
| Molecular weight (kDa) | 70 | 60 | 50 | 50 | 53-57 | 50 | 55 | 55 | 70 | 25 | 25 | |
| Number of variable domains | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Number of CH constant domains | 4 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 4 | 1 | 1 | |
| Length in number of amino acids |
Hinge | 0 | 58 | 15 | 12 | 32, 47 or 62 |
12 | 19 | 6 | 0 | - | - |
| Membrane IG transmembrane region |
25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | - | - | |
| Membrane IG intracytoplamic region |
3 | 3 | 28 | 28 | 28 | 28 | 14 | 14 | 28 | - | - | |
| Secreted IG tailpiece (1) |
20 | 9 | 2 | 2 | 2 | 2 | 20 | 20 | 2 | - | - | |
| N-glycosylation sites (2) | 5 | 3 | 1 | 1 | 2 | 1 | 2 | 4 | 7 | 0 | 0 | |
| O-glycosylation sites (3) | - | 7 | - | - | - | - | 8 | - | - | - | 0 | |
| Allotypes | none | none | G1m | G2m | G3m | G4m | none | A2m | Em | Km | none | |
Notes:
(1) encoded by CH-S (see Chapter 3 of the Immuglobulin FactsBook).
(2) only indicated for the C-REGION.
(3) O-glycosylation sites are located in the delta and alpha1 hinge regions.
Created: Monday, 11-Jul-2011 12:56:59 CEST
Authors: Valérie Thouvenin and Marie-Paule Lefranc
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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