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IMGT Nomenclature Committee (IMGT-NC)

Chairperson

Marie-Paule Lefranc (Marie-Paule.Lefranc@igh.cnrs.fr)
Senior Member of the Institut Universitaire de France; Professor Université Montpellier II
IMGT, LIGM IGH, UPR CNRS 1142, Montpellier, France

Objectives

The IMGT Nomenclature Committee (IMGT-NC) is responsible for the standardized classification and nomenclature of the immunoglobulins (IG) and T cell receptors (TR) of human and other vertebrate species. IMGT-NC Subcommittee for immunoglobulins and T cell receptors, and of the immunoglobulin superfamily (IgSF) and the major histocompatibility superfamily (MhSF) (IMGT-NC Subcommittee for IgSF and MhSF) in IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org [1].

The IMGT-NC Subcommittee for immunoglobulins and T cell receptors is the 'WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors'.

Rules for the nomenclature are described in the IMGT Scientific chart and are based on the concept of CLASSIFICATION of IMGT-ONTOLOGY [2].
WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007 [6,7] pdf

The IMGT Nomenclature Committee (IMGT-NC) is responsible of the coherence of the IG, TR and MH gene and allele nomenclature, as well as that of the related proteins, with the concepts of IDENTIFICATION, DESCRIPTION and NUMEROTATION of IMGT-ONTOLOGY in IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org [1].

IMGT-NC works in close collaboration with

Submission of new V alleles to IMGT-NC

The submission of new alleles of V genes requires:

Sequences from NGS are accepted only for known alleles if they complete the germline genomic sequence in 5' or in 3' (a few alleles may have incomplete sequences in 5' or 3' if they were retrieved from the literature before IMGT/GENE-DB was established).

Although new potential V alleles may be identified from NGS from blood sample DNA amplification, they are not considered by the IMGT nomenclature committee (IMGT-NC) because the sequences are not mapped. If a new V allele is suspected by NGS, its sequence needs to be confirmed from a direct Sanger sequencing from the germline gDNA from the individual, or identified in an existing mapped BAC, cosmid or phage of the alternative genomes on the genome browsers, for submission to IMGT-NC.

References:
[1] Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003) Full text
[2] Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999) PMID:10745995, LIGM:221 pdf
[3] Wain, H.M. et al., Genomics, 79, 464-470 (2002) PMID: 11944974
[4] Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, 458 pages (2001) ISBN: 012441351X
[5] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, 398 pages (2001) ISBN: 0124413528
[6] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007, Dev. Comp. Immunol., 2007 Nov 6 (2007) PMID: 18036660.
[7] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Nov. 2007, Immunogenetics, 59, 899-902 (2007) PMID: 18046549.
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