The 'configuration' concept defines the status of the V, D and J genes before or after DNA rearrangements, respectively. The two main instances of that concept are:
The 'configuration' concept is particularly important because it is unique, in the animal and plant genomes, to the vertebrate IG and TR genes.
Note that the C-GENEs do not rearrange directly and therefore their configuration is undefined.
|||Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999) PMID: 10745995, LIGM:221|