The Academic Press FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field.
The Immunoglobulin FactsBook the first published reference for all functional and ORF immunoglobulin genes. Introductory chapters present up-to-date information on immunoglobulin structural and biological properties, chain synthesis, gene chromosomal localization, and organization of the IGH, IGK and IGL loci. This is followed by entries on all the 203 functional and ORF variable, diversity, joining and constant genes in man, and provides the first complete overview of the potential repertoire of the immunoglobulin heavy, kappa and lambda loci.
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Reviews on the Immunoglobulin FactsBooks
E-STREAMS Vol. 5, No. 8 - August 2002 :
Immunoglobulin FactsBook, by Marie-Paule Lefranc, Gérard Lefranc
San Diego, CA , Academic Press, 2001
The Immunoglobulin FactsBook is part of the very well respected FactsBook series published by Academic Press. The FactsBook series focuses on protein groups, in this case functional and ORF (Open Reading Frame) immunoglobulin or antibody genes.
The authors, Marie-Paul Lefranc and Gérard Lefranc, are from the IMGT, the international ImMunoGeneTics database, Laboratoire d'ImmunoGénétique Moléculaire, Université Montpellier II, Institut de Génétique Humaine CNRS, Montpellier, France, and both have extensive publication records in the field, as well as being involved in the production of the database.
The book starts with four chapters outlining the organization of the entries and explaining the terms used. The types of immunoglobulins are explained, depending on heavy or light chain, whether they are membrane or secreted, biological function, etc. The review of the synthesis of immunoglobulins includes many useful figures. "Chapter 4 represents a major IMGT contribution by providing, in a unique document, the first complete description of the immunoglobulin germline repertoire in humans." The introduction also covers the standardized numbers the IMGT uses.
After the four introductory chapters, section two is the listing of 203 genes and 459 alleles, for a total of 837 sequences displayed. The entries cover nomenclature, definition and functionality, gene location, gene structure (when known), nucleotide and amino acid sequences, framework (FR) and complementarity determining regions (CDR) for the V-GENE entries, Collier de Perles (two-dimensional graphical representations of the immunoglobulin variable regions) and accession numbers from various databases. References are given after the entries for the different groups covered. Updates and new genes, as well as other databases and software for comparisons and other genome work can be found at the web site for IMGT, the international ImMunoGeneTics database, http://www.imgt.org (an extremely useful site for anyone in the field).
Like the rest of the FactsBook series, this volume was published to help high level researchers-graduate students and above. Recommended for medical school libraries and university science libraries supporting advanced molecular biology programs. Many laboratories will want to purchase this volume for easy reference as well.
Source: E-STREAMS (Electronic Reviews of Science & Technology References, August 2002)
E-Streams (http://www.e-streams.com) is a review web site for librarians.
The T cell receptor FactsBook the first published reference for all functional and ORF T cell receptor genes. Introductory chapters provide up-to-date information on T cell receptor structural and biological properties, chain synthesis, gene chromosomal localization, and organization of the TRA, TRB, TRG and TRD loci. This is followed by entries on all the 168 functional and ORF variable, diversity, joining and constant genes in man, and provides the first complete overview of the potential repertoire of the T cell receptor alpha, beta, gamma and delta loci.
- ELSEVIER store (Imprint: Academic Press) : Print Book ISBN :9780124413528, eBook ISBN :9780080542645
- Amazon (USA) Amazon (France)
Reviews on the T cell receptor FactsBooks
E-mail sent by Lee Hood (Systems Biology, Seattle,USA) to the authors on the 12 April 2002
"I consider the T cell Receptor FactsBook an indispensable reference. The T cell Receptor FactsBook has done an outstanding job."
The Immunoglobulin FactsBook and The T cell receptor FactsBook provide information on:
- - assignment to subgroup and nomenclature
- - gene definition and functionality
- - gene location
- - allelic polymorphisms
- - standardization sequence alignments with protein translation
- - framework and complementarity determining regions length
- - two-dimensional representations (or Colliers de Perles)
- - IMGT and EMBL/GenBank accession numbers
- - genome database accession numbers
- - key references
 Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, 458 pages (2001) ISBN:012441351X
 Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, 398 pages (2001) ISBN:0124413528