As examples, for the IG and TR genes, the instances functional (for germline V-GENE, D-GENE, J-GENE, and for C-GENE) and productive (for rearranged V-J and V-D-J genomic or cDNA entities) mean that the coding regions have an open reading frame without stop codon, and that there is no described defect in the splicing sites, and/or recombination signals, and/or regulatory elements. According to the gravity of the identified defects and to the gene configuration, the functionality can be defined as ORF or pseudogene (for germline V-GENE, D-GENE or J-GENE, and for C-GENE) and unproductive (for rearranged V-J and V-D-J genomic or cDNA entities).
For genes other than IG and TR, the functionality instances are the same as "For Germline IG and TR entities and for C-GENE".
Functionality can be queried from the "Taxonomy,..." module in IMGT/LIGM-DB.
Functionality is shown between:
|||Lefranc, M.-P., Exp. Clin. Immunogenet., 15, 1-7 (1998) PMID: 9619395, LIGM: 199|
|||Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999) PMID: 10745995, LIGM: 221|