IMGT®, the international ImMunoGeneTics information system®

logo IMGT

Nomenclature

IMGT nomenclature provides immunologists and geneticists with unique standardized IMGT gene names for the immunoglobulins (IG) or antibodies and T cell receptors (TR) of all jawed vertebrate species (gnathostomata) from fishes to humans, allowing data extraction and comparison of the highly complex and hugely diverse B and T cell antigen receptor repertoires, whatever the species [18].

The IMGT nomenclature of IG and TR genes and alleles is the official nomenclature approved by the IUIS Immunoglobulins (IG), T cell receptors (TR) and Major Histocompatibility (MH) Nomenclature Sub-Committee [16,17].

The WHO-IUIS Nomenclature Subcommitte for Immunoglobulins and T cell receptors report. Aug. 19, 2007. pdf [16,17]

Exhaustive and standardized list of human IG and TR gene names and mouse IG and TR gene names are available from the IMGT Repertoire at the IMGT Web resources [6]. These lists provide links to NCBI (for human), MGD (for mouse), and Entrez Gene entries.

IMGT IG and TR genes at HGNC

Immunoglobulins (IG)
T cell receptors (TR)

Princeps publications on IG and TR gene nomenclature

Lefranc, M.-P. Nomenclature of the human immunoglobulin genes. In: Current Protocols in Immunology (J. E. Coligan, B.E. Bierer, D.E. Margulies, E.M. Shevach and W. Strober, eds.), John Wiley and Sons, Hoboken N.J., pp. A.1P.1-A.1P.37 (2000). LIGM: 230. PMID: 18432650 [6]

Lefranc, M.-P. Nomenclature of the human T cell receptor genes. In: Current Protocols in Immunology (J. E. Coligan, B.E. Bierer, D.E. Margulies, E.M. Shevach and W. Strober, eds.), John Wiley and Sons, Hoboken N.J., pp. A.1O.1-A.1O.23 (2000). LIGM:231. PMID: 18432649 [11]

Lefranc M.-P. and Lefranc G. The Immunoglobulin FactsBook , Academic Press, London, UK, 2001 (458 pages) [7]

Lefranc M.-P. and Lefranc G. The T cell receptor FactsBook , Academic Press, London, UK, 2001 (398 pages) [12]

Lefranc M-P. Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics. Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022. Open access PMID: 24600447 [18] (on invitation of the IUIS Nomenclature Committee)

IMGT/GENE-DB

IMGT/GENE-DB allows to retrieve information on IG and TR genes of human and other jawed vertebrate species (gnathostomata), based on the IMGT gene name nomenclature [15].

on invitation of the IUIS Nomenclature Committee

References:
[1] Giudicelli, V. and Lefranc, M-P., Bioinformatics, 15, 1047-1054 (1999) PMID: 10745995, LIGM:221 pdf
[2] Ghanem, N. et al., Exp. Clin. Immunogenet., 5, 186-195 (1988)on invitation of the IUIS Nomenclature Committee PMID: 2908491, LIGM:63
[3] Bensmana, M. et al., Nucleic Acids Res., 16, 3108 (1988) PMID: 3130612, LIGM:65
[4] Lefranc, M.-P. and Rabbitts, T.H., Trends Biochem. Sci., 14, 214-218 (1989) PMID: 2527426, LIGM:84
[5] Lefranc, M.-P. and Rabbitts, T.H., Res. Immunol., 141, 615-618 (1990) PMID: 2151348, LIGM:126
[6] Lefranc, M.-P., Current Protocols in Immunology, Wiley, J. and Sons, New York, Supplement 40, A.1P.1-A1P.37 (2000), LIGM:230 PMID: 10087405, LIGM:210 pdf
[7]Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, 458 pages (2001) ISBN: 012441351X
[8] Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 100-116 (2001) PMID: 11340299, LIGM:246 pdf
[9] Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 161-174 (2001) PMID: 11549845, LIGM:251 pdf
[10] Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 242-254 (2001) PMID: 11872955, LIGM:254 pdf
[11] Lefranc, M.-P., Current Protocols in Immunology, Wiley, J. and Sons, New York, Supplement 40, A.1O.1-A.1O.23 (2000) LIGM:231
[12] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, 398 pages (2001) ISBN: 0124413528
[13] Wain, H.M. et al., Genomics, 79, 464-470 (2002) PMID: 11944974
[14] Glusman, G. et al., Immunity, 15, 337-349 (2001) PMID: 11567625
[15] Giudicelli, V. et al., Nucl. Acids Res., D593-D597 (2005) PMID: 15608269, LIGM:292
[16] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007, Dev. Comp. Immunol., 2007 Nov 6 (2007), LIGM:336 PMID: 18036660
[17] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Nov. 2007, Immunogenetics, 59, 899-902 (2007), LIGM:334 PMID: 18046549
[18] Lefranc M-P. Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022 Open access PMID: 24600447, LIGM:429