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Polarity

The polarity is the direction of transcription of a V-GENE relative to a J-C-CLUSTER or D-J-C-CLUSTER in a same locus. There are two exclusive instances of 'polarity':

• same polarity as that of the J-C-CLUSTER or D-J-C-CLUSTER
• opposite polarity to that of the J-C-CLUSTER or D-J-C-CLUSTER

A V-GENE with a same polarity as that of the J-C-CLUSTER or D-J-C-CLUSTER rearranges by a deletional joining.
A V-GENE with an opposite polarity to that of the J-C-CLUSTER or D-J-C-CLUSTER rearranges by an inversional joining.

References:

[1]	Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, 398 pages (2001) ISBN:0124413528.

See also:

• Locus

Created: 18/07/2001
Last updated: Wednesday, 29-Jun-2011 17:02:00 CEST
Author: Marie-Paule Lefranc
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc

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