IMGT EC FP5 project
(European Commission
Fifth Framework programme)

Quality of Life and Management of Living Resources (QLG2-2000-01287) implemented in the Fifth Framework programme (1999-2002)

Integrated system to manage the enormous complexity of the genome and proteome of the specific immune response: IMGT, the international ImMunoGeneTics information system®

IMGT Home page

IMGT®, the international ImMunoGeneTics information system®

IMGT coordinator

IMGT® initiator and coordinator: Marie-Paule Lefranc (
Senior member of the Institut Universitaire de France
Chair of Immunogenetics and Immunoinformatics
Professor Université Montpellier 2
CNRS Délégation Languedoc-Roussillon, LIGM, IGH, Montpellier (France)

IMGT EC FP5 partners

PCRDT partners
  • LIGM
    Laboratoire d'ImmunoGénétique Moléculaire, IGH, CNRS, Université Montpellier 2, Montpellier, France
    European Molecular Biology Laboratory-European Bioinformatic Institute, Hinxton, UK
  • CR
    Cancer Research UK, London, UK
    Seraing, Belgium
  • BPRC
    Biomedical Primate Research Centre, Rijswijk, The Netherlands

Overall objectives of the project

IMGT®, the international ImMunoGeneTIcs information system® is one of the most successful and integrated European project. The workplan of the 5th PCRDT focused on the genome and proteome (genes, proteins, polymorphisms and structures) of the immunoglobulins (IG), T cell receptors (TR) and major histocompatibility (MH) of human and other vertebrates. The IMGT consortium managed to go beyond the expected deliverables and milestones with the creation of additional new databases (IMGT/3Dstructure-DB, IMGT/GENE-DB) and tools (IMGT/JunctionAnalysis, IMGT/PhyloGene, IMGT/Allele-Align, IMGT/GeneView, IMGT/GeneSearch, IMGT/LocusView), in addition to those expected in the workplan. Moreover, the IMGT Repertoire (the IMGT major Web resource on IG, TR and MH) has been extended to related proteins of the immune system (RPI), particularly those with V-like, C-like and G-like domains, opening new insights in the evolution of these proteins.

Progress to date

The IMGT Home page is at Montpellier at and provides a common access to a high-quality integrated information system® specializing in IG, TR, MH and RPI of human and other vertebrate species. It comprises:

    Author: Marie-Paule Lefranc
  1. the IMGT databases
  2. IMGT Web resources (8000 pages)
  3. and IMGT interactive tools

The unique common access to IMGT® is the IMGT Home page The IMGT MH sequence databases (human: HLA and nonhuman primates: MH-NHP) are hosted on the EBI server. All the other IMGT databases, resources and tools on IG, TR, MH and RPI are localized at Montpellier on the CINES and IGH servers.

IMGT creations and updates

Workpackages and milestones

Created: 09/05/2003
Last updated: Tuesday, 24-Jun-2014 22:01:04 CEST
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text. Nucleic Acids Res. 2015 Jan 28;43(Database issue):D413-422. doi: 10.1093/nar/gku1056. Epub 2014 Nov 5. Full text.

IMGT founder and Executive Director Emeritus: Marie-Paule Lefranc
IMGT director: Sofia Kossida
Bioinformatics manager: Véronique Giudicelli
Computer manager: Patrice Duroux
Webmaster: Amélie Houles
  Université de Montpellier   

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