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Archives

About IMGT

Only major updates are reported here.
Other updates are reported in individual pages or chapters.

2009

23 December 2009 - CREATION: Alignments of alleles: Dog Canis lupus familiaris TRGC in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Dog Canis lupus familiaris TRG C-REGIONs

15 December 2009 - CREATION: Alignments of alleles: Dog Canis lupus familiaris TRGV in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Dog Canis lupus familiaris TRG V-REGIONs

11 December 2009 - CREATION: Alignments of alleles: Dog Canis lupus familiaris TRGJ in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Dog Canis lupus familiaris TRG J-REGIONs

04 December 2009 - IMGT/mAb-DB is on-line

  1. IMGT/mAb-DB Query page is on-line in IMGT monoclonal antibodies database
  2. IMGT/mAb-DB Documentation is on-line in IMGT monoclonal antibodies database

30 November 2009 - UPDATE: Protein display: Norway rat (Rattus norvegicus) IGHC in IMGT Repertoire (IG and TR)

  1. Addition of amino acids resulting from the splicing in the Protein display: Norway rat (Rattus norvegicus) IGH C-REGIONs in IMGT Repertoire

25 November 2009 - CREATION: Protein displays: Dog (Canis lupus familiaris) TRGJ and TRGC in IMGT Repertoire (IG and TR)

  1. Creation of Protein display: Dog (Canis lupus familiaris) TRG J-REGIONs in IMGT Repertoire
  2. Creation of Protein display: Dog (Canis lupus familiaris) TRG C-REGIONs in IMGT Repertoire

02 November 2009 - UPDATE of IMGT/3Dstructure-DB (Version 4.0.0) and Related other IMGT® resources

  1. Update of Web interfaces for IMGT/3Dstructure-DB database and IMGT/DomainDisplay, IMGT/DomainGapAlign, IMGT/Collier-de-Perles and IMGT/StructuralQuery tools.
    • Improvements of the web interfaces (5 types of search, linked lists, ...)
    • Improvement of Sequence in IMGT format in the IMGT/3Dstructure-DB card, 'Chain sequence' section:
      • Plain (FASTA format)
      • With regions and domains
      • With FR-IMGT and CDR-IMGT
      • With cysteins involved in disulfide bridges and with N-glycosylation sites (INN entries)
      • With N-glycosylation sites (PDB entries)
    • Update of the IMGT domain reference directory from the IMGT/GENE-DB database. Addition of 163 Rattus norvegicus IGKV genes and alleles (136 functional, 6 ORF and 21 pseudogenes).
    • Update of IMGT/DomainGapAlign tool:
      • Improvement of the Web interface and the display of results
      • Highlight of the amino acids changes between the closest germline V-REGION (for 'V') or C-DOMAIN (for 'C) and the sequences submitted by users
      • IMGT mutation and AA change description (see IMGT amino acid classes)
      • Results summary (corresponding to the closest genes and alleles) with: CDR-IMGT lengths, Number of different AA in CDR-IMGT (CDR3 not included), FR-IMGT lengths, Number of different AA in FR-IMGT, Number of AA class changes and List of AA class changes.
    • Update of 3D visualization with Jmol:
      • The whole chain sequences are displayed in a box, indicating th chain ID, the IMGT Receptor description and the lenght of the chain. Users just have to click on a residue in sequences to visualize it in the Jmol applet (wireframe by default)
      • The interface is now composed of 5 sub-menus: Selection, View, coloration, IMGT and Paratope/epitope
      • Go to 3D visualization with Jmol for more details.

20 November 2009 - CREATION: Gene tables: Dog (Canis lupus familiaris) TRGJ and TRGC in IMGT Repertoire (IG and TR)

  1. Creation of the Gene table: Dog (Canis lupus familiaris) TRGJ in IMGT Repertoire
  2. Creation of the Gene table: Dog (Canis lupus familiaris) TRGC in IMGT Repertoire

21 October 2009 - UPDATE: Norway rat (Rattus norvegicus) IGKV, J and C in IMGT/GENE-DB

  1. Addition of 163 IGKV gapped sequences IMGT/GENE-DB
  2. Addition of 7 IGKJ sequences IMGT/GENE-DB
  3. Addition of 2 IGKC gapped sequences IMGT/GENE-DB

17 July 2009 - UPDATE: Dog (Canis lupus familiaris) TRGC in IMGT/GENE-DB

  1. Addition of artificially spliced exon(s) for functional and ORF TRGC genes in IMGT/GENE-DB

02 June 2009 - UPDATE of IMGT/Education

  1. Creation new pages IMGT Education Tutorials MHC

13 May 2009 - UPDATE: Norway rat (Rattus norvegicus) IGHC in IMGT/GENE-DB

  1. Addition of artificially spliced exon(s) for functional and ORF IGHC genes in IMGT/GENE-DB

07 May 2009 - Update of IMGT Repertoire (MH) and IMGT Repertoire (RPI)

  1. IMGT Repertoire MHC: addition of Oncorhynchus mykiss (rainbow trout) MHC-I and MHC-II genes.
  2. IMGT Repertoire RPI: update of MICA alleles, update of RPI entries.

29 April 2009 - CREATION: Protein display: Dog (Canis lupus familiaris) TRG V-REGIONs in IMGT Repertoire (IG and TR)

  1. Creation of the Protein display: Dog (Canis lupus familiaris) TRG V-REGIONs in IMGT Repertoire

27 April 2009 - UPDATE of IMGT/V-QUEST (Version 3.2.0)

  1. Addition of "Export in Excel file output : the "Detailed view" results are recorded in 11 sheets.
  2. Query Page : the option "2. Alignment for D-GENE" of "A. Detailed view" is no more selected by default.
  3. A. Detailed view results:
    • In "Result summary", D-GENE(s) and allele(s) are shown only if identified by IMGT/JunctionAnalysis"
    • In "4. Results of IMGT/JunctionAnalysis"
      • In case of unmutated IGK or IGL V-GENE (no mutations in FR1-IMGT, CDR1-IMGT, FR2-IMGT, CDR2-IMGT and FR3-IMGT), the number of allowed mutations in 3'V-REGION and 5'J-REGION has been set to 2.
      • The number of accepted D-GENE in the junction is indicated
    • In "10. V-REGION mutation statistics": update of the presentation of the amino acid table
    • In "11. V-REGION mutation hot spots": the tables are displayed as follow: (a/t)a, t(a/t), (a/g)g(c/t)(a/t), (a/t)(a/g)c(c/t)
    • In "13. Sequences of V-, V-J- or V-D-J- REGION ('nt' and 'AA') with gaps in FASTA": the V-J- or V-D-J- REGION amino acid sequences are shown in red for unproductive sequences with an out-of-frame junction.
  4. "Export in text" output : elimination of HTML tags (except for option "5. V-REGION protein display with colored AA according to the AA IMGT Classes" of Synthesis View).
  5. "B. Synthesis view results": in "7. V-REGION most frequently occurring AA per position and per FR-IMGT and CDR-IMGT", a message is added when, at a given position, 100% of the analyzed sequences have the same AA change.
  6. Update of IMGT gap positions in Homo sapiens IGHV3-72*02.