IMGT/3Dstructure-DB card: 1igt

Mouse rearranged IGH V-D-J2 REGION [8.8.11]

The Collier de Perles (in space) shows on the forefront the strands located at the interface with the the Ig-Light chain V-DOMAIN. Hydrogen bonds between these strands (G, F, C, C', C'') are represented by green lines. On the back are shown the strands located on the external face of the Ig-Heavy chain V-DOMAIN.

Legend:

• Amino acids are shown in the one-letter abbreviation.
• Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50 % of analysed Ig and TcR sequences are shown in blue.
• All Proline (P) are shown in yellow.
• The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT. The CDR3-IMGT is described using the IMGT unique numbering for V-DOMAIN.
• Hatched circles or squares correspond to missing positions according to the IMGT unique numbering for V-REGIONs. Missing positions of the CDRs are not shown in this representation.
• Arrows indicate the direction of the beta strands and their different designations in 3D structure.
• CDR-IMGT regions are colored according to the IMGT color menu.

Created: 19/12/97
Last updated: Tuesday, 15-Nov-2011 12:03:14 CET
Author: Manuel Ruiz
Contact: Marie-Paule Lefranc

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