Germline gene and allele table: Mouse (Mus musculus) IGHV

Click here to see Correspondence between the different mouse IGHV subgroup nomenclatures

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T), and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between:
- parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
- brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Reference sequences in bold have been mapped: "mapped" refers to sequences which have been obtained from clones (phages, cosmids, YACs...) either by subcloning or PCR, and does not apply to sequences obtained directly from genomic DNA.

Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).

Click on the strain name to get information on the strain (link to MGD)
In the "Sequences from the literature" column, names of the sequences are preceded by the designation of the mouse strain.

Mouse (Mus musculus) gene names and IGHV allele names are provisional. Definitive gene and allele nomenclature will be assigned once the complete genomic sequence of the mouse IGH locus will be made publicly available.

For a given gene name, each horizontal line corresponds to a different allele. For more information, see Alignments of alleles and Tables of alleles (IMGT Repertoire).

The 15 mouse (Mus musculus) IGHV subgroups form three clans (Figure IGHV clans), which comprise, respectively:

IGHV subgroup IGHV
gene name
IGHV
allele name
Fct R T Pr Strains Reference sequences Accession numbers Sequences from the literature
1 IGHV1S1 1S1*01 F + +   C57BL/6 V186-1 J00532 [3]  
IGHV1S2 1S2*01 F + +   C57BL/6 V186-2 J00530 [3] C57BL/6, V186-2 [M60252][46]
IGHV1S3 1S3*01 F       C57BL/6 V145 J00533 [3] C57BL/6, C1egc [L26936][61]°
IGHV1S4 1S4*01 F       C57BL/6 V23 J00534 [3] C57BL/6, C3egc [L26852][61]°,
C57BL/6, C35e [L26855][61]°,
C57BL/6, C44e [L26859][61]°,
C57BL/6, C45g [L26864][61]°
IGHV1S5 1S5*01 F       C57BL/6 V6 J00535 [3] C57BL/6, C9gc [L26866][61](36)(41)°
IGHV1S6 1S6*01 F + + + C57BL/6 V3 J00536 [3]  
IGHV1S7 1S7*01 F +     C57BL/6 V102 J00537 [3](1)  
IGHV1S8 1S8*01 F + + + BALB/c V108A J00488 [5]  
IGHV1S9 1S9*01 P(2)       BALB/c V108B J00511 [10]  
IGHV1S10 1S10*01 P(3)       BALB/c V104A X06864/M31015 [30] BALB/c, V104A [J00503][5](4)
IGHV1S11 1S11*01 P(5)       BALB/c V111 J00513 [10]  
IGHV1S12 1S12*01 F       BALB/c VH105 J00507 [10]  
IGHV1S13 1S13*01 F + +   BALB/c VH124 X00160 [12]  
IGHV1S14 1S14*01 F       BALB/c VH104B K00707/X00161 [12]  
IGHV1S15 1S15*01 P(6)       BALB/c VH3 K00603 [13]  
IGHV1S16 1S16*01 P(7)       BALB/c VH33 K00604 [13]  
IGHV1S17 1S17*01 P(8)       BALB/c VH28 K00605 [13]  
IGHV1S18 1S18*01 P(9)       BALB/c VH5 K00606 [13]  
IGHV1S19 1S19*01 P(10)       BALB/c VH31 K00607 [13]  
IGHV1S20 1S20*01 F + + + A/J VH-Id-11 K02153 [15](11)  
IGHV1S21 1S21*01 F       A/J VH-Id-7 K02154 [15](12) A/J, VH-Id-14 [K02155][15](12)
1S21*02 [F]       A/J MH X05745 [31](13)°  
IGHV1S22 1S22*01 F         MVAR 1 X02063 [16](14) BALB/c, J558.e [AF304549][73]°
IGHV1S23 1S23*01 F         MVAR 2\10 X02064 [16]  
IGHV1S24 1S24*01 F         MVARG2 X02065 [16](14)  
IGHV1S25 1S25*01 F         MVAR11 X02066 [16](14)  
IGHV1S26 1S26*01 F       BALB/c H30 X02458 [23](14)  
IGHV1S27 1S27*01 F + +   BALB/c H13-3 X02459 [23]  
IGHV1S28 1S28*01 P(15)       BALB/c H24 X02460 [23]  
IGHV1S29 1S29*01 F + + + BALB/c H16 X02461 [23](18)  
IGHV1S30 1S30*01 P(17)       BALB/c H26-1 X02462 [23]  
1S30*02 F       BALB/c pHC103 D13201 [52](14)  
IGHV1S31 1S31*01 F       BALB/c H8 X02463 [23](19)  
IGHV1S32 1S32*01 F       BALB/c H9 X02464 [23](19)  
IGHV1S33 1S33*01 F + + + BALB/c H13-1 X02465 [23](16) A1/A4 [M13787][26](21)c
IGHV1S34 1S34*01 F + +   BALB/c H26-6 X02467 [23](20)  
IGHV1S35 1S35*01 F       BALB/c pcDFL.1 M12376 [24](21)c  
IGHV1S36 1S36*01 F         B4 M13788 [26](21)c  
IGHV1S37 1S37*01 F         A5 M13789 [26](22)c  
IGHV1S38 1S38*01 F       BALB/c H130 M17950 [35] H18 [X02468][23](16)
IGHV1S39 1S39*01 P(23)       BALB/c VAR104 M17574 [30]  
IGHV1S40 1S40*01 F       BALB/c VAR100 M17575 [30]  
IGHV1S41 1S41*01 F + +   BALB/c VAR32 X06868 [30](24)  
IGHV1S42 1S42*01 P(25)       BALB/c pHC104 D13202 [52]  
1S42*02 P(26)       BALB/c VAR34 M17696 [30]  
IGHV1S43 1S43*01 [F] + + + A/J VhId(CR) X05746 [31](27)°  
IGHV1S44 1S44*01 [F]       I/St L13 M19402 [37](28)°  
IGHV1S45 1S45*01 F +     I/St L15 M19403 [37](29)  
IGHV1S46 1S46*01 [F]       I/St L7.1 M20774 [37]°  
IGHV1S47 1S47*01 ORF(30)       A/J VH15 M34977 [39]  
IGHV1S48 1S48*01 P(31)       A/J VH1.3 M34978 [39]  
IGHV1S49 1S49*01 F       A/J VH186 M34979 [39]  
IGHV1S50 1S50*01 F       A/J VH83 M34980 [39]  
IGHV1S51 1S51*01 P(32)       A/J VH122B M34981 [39]  
IGHV1S52 1S52*01 F + + + A/J VH1.8 M34982 [39]  
IGHV1S53 1S53*01 F       A/J VH43X M34983 [39]  
1S53*02 F + +   BALB/c VHATAG-1 L14547 [58](33) BALB/c, H17 [X02466][23](16)
IGHV1S54 1S54*01 F       A/J VH21 M34984 [39](91)  
IGHV1S55 1S55*01 F       A/J VH122T M34985 [39]  
IGHV1S56 1S56*01 F +     A/J VH43Y M34987 [39]  
IGHV1S57 1S57*01 P(34)       BALB/c pHC102 D13200 [52]  
IGHV1S58 1S58*01 F       BALB/c VHATAG-2 L14548 [58] BALB/c, J558.k [AF304555][73]°
IGHV1S59 1S59*01 F + + + MRL/lpr GLvh50 L17134 [56]  
IGHV1S60 1S60*01 F + + + MRL/lpr GN1 D14633 [63]  
IGHV1S61 1S61*01 F + + + MRL/lpr GN2 D14634 [64]  
IGHV1S62 1S62*01 [F]       C57BL/6 C22e L26851 [61](35)°  
IGHV1S63 1S63*01 [F]       C57BL/6 C31e L26853 [61](35)°  
1S63*02 [F]       C57BL/6 C44gc L26863 [61](35)(47)°  
IGHV1S64 1S64*01 [F]       C57BL/6 C33eg L26854 [61](35)° C57BL/6J, CHS1.22 [AF025444][68](35)°
IGHV1S65 1S65*01 [F]       C57BL/6 C36e L26856 [61](35)°  
IGHV1S66 1S66*01 [F]       C57BL/6 C38e L26857 [61](35)°  
IGHV1S67 1S67*01 [F]       C57BL/6 C40c L26858 [61](35)°  
1S67*02 [F]       BALB/c BHS2.18 AF025447 [68](35)(42)°  
IGHV1S68 1S68*01 [F]       C57BL/6 C6e L26860 [61](35)°  
IGHV1S69 1S69*01 [F]       C57BL/6 C8g L26865 [61](35)° C57BL/6, C16c [L26928][61](35)
IGHV1S70 1S70*01 [F]       BALB/c B1c L26867 [61](35)°  
IGHV1S71 1S71*01 [F]       BALB/c B10c L26868 [61](35)°  
IGHV1S72 1S72*01 [F]       BALB/c B12c L26869 [61](35)°  
IGHV1S73 1S73*01 [F]       BALB/c B13c L26870 [61](35)°  
IGHV1S74 1S74*01 [P](37)       BALB/c B13e L26871 [61](35)°  
IGHV1S75 1S75*01 [F]       BALB/c B14e L26872 [61](35)° BALB/c, B2c [L26876][61](35)°,
BALB/c, B5e [L26884][61](35)°
IGHV1S76 1S76*01 [P](38)       BALB/c B16c L26873 [61](35)°  
IGHV1S77 1S77*01 [F]       BALB/c B16e L26874 [61](35)° BALB/c, B9c [L26887][61](35)°
IGHV1S78 1S78*01 [F]       BALB/c B18c L26875 [61](35)°  
IGHV1S79 1S79*01 [F]       BALB/c B20c L26877 [61](35)°  
IGHV1S80 1S80*01 [F]       BALB/c B21c L26878 [61](35)°  
IGHV1S81 1S81*01 [F]       BALB/c B25c L26880 [61](35)°  
IGHV1S82 1S82*01 [F]       BALB/c B26c L26881 [61](35)°  
IGHV1S83 1S83*01 [F]       BALB/c B3e L26882 [61](35)°  
IGHV1S84 1S84*01 [P](38)       BALB/c B4c L26883 [61](35)°  
IGHV1S85 1S85*01 [F]       BALB/c B6c L26885 [61](35)°  
IGHV1S86 1S86*01 [F]       BALB/c B7c L26886 [61](35)°  
IGHV1S87 1S87*01 [F]       C57BL/6 C11c L26925 [61](35)°  
IGHV1S88 1S88*01 [P](39)       C57BL/6 C14c L26926 [61](35)°  
IGHV1S89 1S89*01 [F]       C57BL/6 C15c L26927 [61](35)°  
IGHV1S90 1S90*01 [F]       C57BL/6 C19c L26929 [61](35)°  
IGHV1S91 1S91*01 [F]       C57BL/6 C2c L26930 [61](35)°  
IGHV1S92 1S92*01 [F]       C57BL/6 C20c L26931 [61](35)°  
IGHV1S93 1S93*01 [F]       C57BL/6 C22c L26932 [61](35)°  
IGHV1S94 1S94*01 [F]       C57BL/6 C23c L26933 [61](35)°  
1S94*02 [F]       C57BL/6 C10gc L26861 [61](35)° C57BL/6, C11g [L26862][61](35)°,
C57BL/6, B23c [L26879][61](35)°
IGHV1S95 1S95*01 [F]       C57BL/6 C25c L26934 [61](35)°  
IGHV1S96 1S96*01 [F]       C57BL/6 C26c L26935 [61](35)°  
IGHV1S97 1S97*01 [F]       C57BL/6 C27c L26952 [61](35)°  
IGHV1S98 1S98*01 [F]       C57BL/6 C46g L27628 [61](35)°  
IGHV1S99 1S99*01 [F]       C57BL/6 C57C18 L33933 [61](35)° C57BL/6, C57G14 [L33935][61]°,
C57BL/6, C57G3 [L33938][61]°,
C57BL/6, C57C9 [L33949][61]°
IGHV1S100 1S100*01 [F]       C57BL/6 C57C27 L33934 [61](35)° C57BL/6, C57G6 [L33939][61]°
IGHV1S101 1S101*01 [P](40)       C57BL/6 C57G15 L33936 [61](35)°  
1S101*02 [P]       C57BL/6 C57G18 L33950 [61](35)(43)°  
IGHV1S102 1S102*01 [F]       C57BL/6 C57C16 L33940 [61](35)° C57Bl/6, C57G26 [L33937][61](35)°
IGHV1S103 1S103*01 [F]       C57BL/6 C57C2 L33942 [61](35)°  
IGHV1S104 1S104*01 [P](40)       C57BL/6 C57C44 L33943 [61](35)°  
IGHV1S105 1S105*01 [P](44)       C57BL/6 C57C48 L33944 [61](35)°  
IGHV1S106 1S106*01 [F]       C57BL/6 C57G1 L33945 [61](35)°  
IGHV1S107 1S107*01 [F]       C57BL/6 C57G5 L33946 [61](35)°  
IGHV1S108 1S108*01 [F]       C57BL/6 C57G9 L33947 [61](35)°  
IGHV1S109 1S109*01 [P](45)       C57BL/6 C57G30 L33948 [61](35)°  
IGHV1S110 1S110*01 [P](40)       C57BL/6 C57G22 L33951 [61](35)°  
IGHV1S111 1S111*01 [F]       BALB/c BALB11 L33952 [61](35)°  
IGHV1S112 1S112*01 [P](46)       BALB/c BALB13 L33953 [61](35)° BALB/c, BALB58 [L33956][61]°
IGHV1S113 1S113*01 [F]       BALB/c BALB17 L33954 [61](35)°  
IGHV1S114 1S114*01 [F]       BALB/c BALB19 L33955 [61](35)°  
IGHV1S115 1S115*01 [F]       BALB/c BALB6 L33957 [61](35)°  
IGHV1S116 1S116*01 [F]       BALB/c BALB67 L33958 [61](35)°  
IGHV1S117 1S117*01 [F]       BALB/c BALB71 L33959 [61](35)°  
IGHV1S118 1S118*01 [F]       BALB/c BALB8 L33960 [61](35)°  
IGHV1S119 1S119*01 [F]       BALB/c BALB9 L33961 [61](35)°  
IGHV1S120 1S120*01 [F]       BALB/c BHS2.2 AF025443 [68](35)°  
IGHV1S121 1S121*01 [F]       BALB/c BHS2.19 AF025445 [68](35)°  
IGHV1S122 1S122*01 [F]       BALB/c BHS2.9 AF025446 [68](35)°  
IGHV1S123 1S123*01 [F]       BALB/c BHS2.23 AF025448 [68](35)°  
IGHV1S124 1S124*01 [P](93)       BALB/c BHS2.7 AF025449 [68](35)°  
IGHV1S125 1S125*01 [F]       BALB/c F102 AF305910 [73]°  
IGHV1S126 1S126*01 [F]       BALB/c J558.a AF304545 [73]°  
IGHV1S127 1S127*01 [F]       BALB/c J558.b AF304546 [73]°  
IGHV1S128 1S128*01 [F]       BALB/c J558.c AF304547 [73]°  
IGHV1S129 1S129*01 [F]       BALB/c J558.d AF304548 [73]°  
IGHV1S130 1S130*01 [F]       BALB/c J558.f AF304550 [73]° BALB/c, BHS2.14 [AF049607][69](35)°
IGHV1S131 1S131*01 [F]       BALB/c J558.g AF304551 [73]°  
IGHV1S132 1S132*01 [F]       BALB/c J558.h AF304552 [73]°  
IGHV1S133 1S133*01 [F]       BALB/c J558.i AF304553 [73]°  
IGHV1S134 1S134*01 [F]       BALB/c J558.j AF304554 [73]°  
IGHV1S135 1S135*01 [F]       BALB/c J558.l AF304556 [73]°  
IGHV1S136 1S136*01 [F]       BALB/c J558.m AF304557 [73]°  
IGHV1S137 1S137*01 [F]       BALB/c J558.n AF304558 [73]°  
2 IGHV2S1 2S1*01 F + +     PJ14 V00767 [2]  
IGHV2S2 2S2*01 F + +   BALB/c VH101 J00502 [11] BALB/c, VH101 [M36690][6](48)
IGHV2S3 2S3*01 F       NFS Q5SH.100 M27021 [43]  
IGHV2S4 2S4*01 F + +   BALB/c VOx-1 U53526 [65]  
IGHV2S5 2S5*01 F       BALB/c OX2 [59](49) [X01436][18]#g,
[M21165][33]#g,
[M21166][33]#g
3 IGHV3S1 3S1*01 F + + + A/J SA-5.1 K01569 [20] A/J, SA-5.1 [K02791][17](50)
3S1*02 F + + + BALB/c 1210.7 (cloneSB-2.1) K02790 [17](51)  
IGHV3S2 3S2*01 F + + + BALB/c SB32 M12435 [27](52)  
IGHV3S3 3S3*01 F + + + BALB/b VH3A1 M61217 [47](53)  
IGHV3S4 3S4*01 F       BALB/c   D13203 [52](54)  
IGHV3S5 3S5*01 [F]       C57BL VH36-60 AF171065 [72](55)°  
IGHV3S6 3S6*01 (F)(56)       BALB/c 37.1.1 AJ223544 [29]#c  
IGHV3S7 3S7*01 (F)       C57BL/6 42.7C11.2 AJ223545 [29]#c  
4 IGHV4S1 4S1*01 F + + + BALB/c VH441 V00774 [9]  
IGHV4S2 4S2*01 F + + + BALB/c VH55 X01437 [19]  
5 IGHV5S1 5S1*01 F       BALB/c VH81X (7183.1) X01113 [21]  
5S1*02 [F]       C57BL/6 VH7183.1b AF120460 [71](57)°  
IGHV5S2 5S2*01 F       129/Sv VHD6.96 (7183.2) AF290969 [74]  
IGHV5S3 5S3*01 F + + + BALB/c VH283 (7183.3) X00163 [14]  
5S3*02 [F]       C57BL/6 VH7183.3b AF120472 [71](57)(58)°  
IGHV5S4 5S4*01 F + +   BALB/c VH37.1 (7183.4) X03399 [19]  
5S4*02 F       129/Sv 37.1 AF290967 [74](49)  
IGHV5S5 5S5*01 F + +   BALB/c VH50.1 (7183.5) X03400 [19] 129/Sv, 50.1 [AF039070][74]
5S5*02 [F]       C57BL/6 VH7183.5b AF120473 [71](57)(60)°  
IGHV5S6 5S6*01 F + +   129/Sv VH3:3.39 (7183.7) AF290959 [74]  
5S6*02 [F]       C57BL/6 VH7183.7b AF120474 [71](57)°  
IGHV5S7 5S7*01 P(62)       129/Sv VHE4-psi (7183.8) AF290964 [74] BALB/c, [K02889][21]#g
IGHV5S8 5S8*01 F + +   BALB/c VH10-19 X59817 [51]  
IGHV5S9 5S9*01 F       129/Sv 7183.9 AF290971 [74] BALB/c, VH7183.9 [X67407][49]
BALB/c, 76-1BG [U04231][60](65)°
IGHV5S10 5S10*01 F + +   129/Sv 7183.10 AF290962 [74] BALB/c, VH7183.10 [X67408][49](63)°
IGHV5S11 5S11*01 [F] + +   BALB/c VH7183.11 X67409 [49](63) °  
5S11*02 [F]       C57BL/6 VH7183.11b AF120459 [71](61)°  
IGHV5S12 5S12*01 [F] + + + BALB/c 57-1M (7183.12) U04228 [60](65)° BALB/c, VH7183.12 [X67410][49]
IGHV5S13 5S13*01 F       129/Sv 7183.13 AF290963 [74](63) BALB/c, VH7183.13 [X67411][49](63)°
IGHV5S14 5S14*01 F       129/Sv 7183.14 AF290968 [74] BALB/c, VH7183.14 [X67412][49](63)°
IGHV5S15 5S15*01 F + + + 129/Sv 68-5N
(7183.16)
AF290966 [74](64) BALB/c, 68-5N [U04230][60](65)°
IGHV5S16 5S16*01 F       129/Sv 98-3G
(7183.17)
AF290961 [74] BALB/c, 98-3G [U04232][60](66)°
IGHV5S17 5S17*01 F +     BALB/c 69-1
(7183.18)
U04227 [60]  
IGHV5S18 5S18*01 F + + + 129/Sv 61-1P
(7183.19)
AF290972 [74] BALB/c, 61-1P [U04229][60](65)°
IGHV5S19 5S19*01 [F]       C57BL/6 VH7183.21b AF120461 [71](57)°  
IGHV5S20 5S20*01 (F) + + + C57BL/6 VH7183.22b AF120462 [71](57)#g  
IGHV5S21 5S21*01 [F]       C57BL/6 VH7183.23b AF120463 [71](57)°  
IGHV5S22 5S22*01 [F]       C57BL/6 VH7183.26b AF120465 [71](57)°  
IGHV5S23 5S23*01 [F]       C57BL/6 VH7183.27b AF120466 [71](57)°  
IGHV5S24 5S24*01 [F]       C57BL/6 VH7183.30b AF120469 [71](57)°  
IGHV5S25 5S25*01 [F]       C57BL/6 VH7183.31b AF120470 [71](57)°  
IGHV5S26 5S26*01 [F]       C57BL/6 VH7183.32b AF120471 [71](57)°  
6 IGHV6S1 6S1*01 F       BALB/c 22.1 X03398 [19]  
IGHV6S2 6S2*01 [F]       BALB/c V3 K00692 [8](67)°  
IGHV6S3 6S3*01 [F]       BALB/c V6 K00693 [8](67)°  
IGHV6S4 6S4*01 [F]       BALB/c VH76 K00694 [8](68)°  
7 IGHV7S1 7S1*01 F + + + BALB/c V1 V00758 [1](69) BALB/c, V1 [J00538](90),
BALB/c, V1 [M16723][34],
CLA-2, V1 [X17402][41]
7S1*02 F       C57BL/10 V1 X03253 [22]  
IGHV7S2 7S2*01 P(70)       BALB/c V3 J00500 [7] BALB/c, V3 [J00524][4](71)
BALB/c, V3 [M16724][34](72)
IGHV7S3 7S3*01 F + + + BALB/c V11 J00525 [4] BALB/c, V11 [M16725][34]
7S3*02 F + +   C57BL/10 V11 X03256 [22]  
7S3*03 F + +   NZB V11 M20457 [36] NZW, V11 [M20458][36]
7S3*04 F       C57BL/10 V3 X03254 [22]  
IGHV7S4 7S4*01 F       BALB/c V13 M16726 [34] BALB/c, V13 [J00526][4](73)
7S4*02 F       C57BL/10 V13 X03255 [22]  
8 IGHV8S1 8S1*01 P(74) +     BALB/c V31 X03302 [25] VMU-3.1 [X03303][25]#g
IGHV8S2 8S2*01 P(75)         Pkp66 U14945 [62]  
IGHV8S4 8S4*01 [F]       C57BL/6 CB17H-1 U23019 [66](76)°  
IGHV8S5 8S5*01 [F]       C57BL/6 CB17H-10 U23020 [66](76)°  
IGHV8S6 8S6*01 [P](77)       C57BL/6 CB17H-2 U23021 [66](76)°  
IGHV8S7 8S7*01 [F]       C57BL/6 CB17H-3 U23022 [66](76)°  
IGHV8S8 8S8*01 [F]       C57BL/6 CB17H-6 U23023 [66](76)°  
IGHV8S9 8S9*01 [F]       C57BL/6 CB17H-8 U23024 [66](76)°  
IGHV8S10 8S10*01 [P](78)       C57BL/6 CB17H-9 U23025 [66](76)°  
9 IGHV9S1 9S1*01 F       BALB/c 161 Z15020 [54](79)  
IGHV9S2 9S2*01 F       BALB/c 141 Z15021 [54](79) BALB/K, VGK3 [L14365][57],
BALB/c, VMS1 [53]
IGHV9S3 9S3*01 F + + + BALB/c 251 Z15022 [54](79) BALB/K, VGK1A [L14362][57],
BALB/c, VMS9 [53]
9S3*02 F + + + BALB.K VGK1B L14363 [57](80) BALB/c, VFM11 [53]
IGHV9S4 9S4*01 F + + + BALB/c 281 Z15023 [54] BALB.K, VGK7 [L14369][57],
BALB/c, VFM1 [53]
IGHV9S5 9S5*01 F       BALB.K VGK2 L14364 [57](82)  
IGHV9S6 9S6*01 F + + + BALB.K VGK4 L14366 [57](81) BALB/c, VMS2 [53]
IGHV9S7 9S7*01 F       BALB.K VGK5 L14367 [57](92)  
IGHV9S8 9S8*01 F       BALB.K VGK6 L14368 [57](81)  
10 IGHV10S1 10S1*01 F + +   C57BL/10 B4 (VH10.1b) AF064442 [70]  
10S1*02 F + +   BALB/c C9.5 (VH10.1a) AF064444 [70](83)  
IGHV10S2 10S2*01 F + +   C57BL/10 B12 (VH10.2b) AF064443 [70]  
10S2*02 F + +   BALB/c C8 (VH10.2a) AF064445 [70](84)  
IGHV10S3 10S3*01 F + +   BALB/c C6 (VH10.3a) AF064446 [70]  
IGHV10S4 10S4*01 F + + + MRL/lpr 0401-13 [50](49) MRL/lpr, MRL-DNA4 [M21470][38](86)#c
IGHV10S5 10S5*01 P(85)       MRL/lpr 0401-4 [50](49) MRL/lpr, MRL-RF24BG [X16801][32](87)#c
11 IGHV11S1 11S1*01 (F)       BALB/c CP8
(clone pCP12)
M35502/Y00743 [40]#c  
12 IGHV12S1 12S1*01 (F)         HY1-1H2 M22439 [42]#c  
IGHV12S2 12S2*01 (P)(88)         16-A M26465 [44]#c  
13 IGHV13S1 13S1*01 (F)(89)       NZB 3609N X55935 [48]#g  
14 IGHV14S1 14S1*01 F + + + BALB/c H10 X03571 [28]  
IGHV14S2 14S2*01 F       BALB/c H4a-3 X03572 [28]  
IGHV14S3 14S3*01 F + + + BALB/c H2b-3 X03573 [28]  
IGHV14S4 14S4*01 (F)       MRL/lpr SM7-13 X55934 [48]#g  
15 IGHV15S1 15S1*01 (F)       BALB/c VH15A U39293 [67]#c  
° genomic DNA, but not known as being germline or rearranged.
#c: rearranged cDNA, #g: rearranged genomic DNA
c: cDNA

IMGT notes:
(1) The sequence described in the manuscript is different from the one submitted to the EMBL data library. Nucleotide a at position 261 in EMBL flat file (codon 11 in FR1-IMGT), nucleotide g in the manuscript.
(2) No INIT-CODON in L-PART1, and non canonical V-HEPTAMER: cacagcg instead of cacagtg.
(3) In frame STOP-CODON (positions 300-302) at codon 44 in FR2-IMGT.
(4) Four nucleotides of the V-REGION of the V104A sequence from Givol et al. [5] were corrected by Blankestein et al. [30]. Nucleotides gc at positions 1096-1097 in EMBL flat file are replaced by nucleotides ca (g148>c, c149>a, A55>Q in the IMGT unique V-REGION numbering), nucleotide g at position 1111 is replaced by nucleotide a (g163>a, G60>S in CDR2-IMGT) and nucleotide c at position 1132 is replaced by g (c184>g, Q69>E in FR3-IMGT).
(5) In frame STOP-CODON (positions 1031-1033) at codon 102 in FR3-IMGT, and non canonical V-HEPTAMER: cacagcg instead of cacagtg.
(6) In frame STOP-CODON (positions 309-311) at codon 41 instead of the CONSERVED-TRP in FR2-IMGT.
(7) In frame STOP-CODON (positions 319-321) at codon 44 in FR2-IMGT.
(8) No INIT-CODON in L-PART1, and non canonical V-HEPTAMER: gacagtg instead of cacagtg.
(9) In frame STOP-CODON (positions 62-64) at codon 1 in FR1-IMGT.
(10) In frame STOP-CODON (positions 286-288) at codon 55 in FR2-IMGT.
(11) Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent).
(12) Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent) and partial FR3-IMGT (AA 100 to 104 are absent).
(13) Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent) and partial FR3-IMGT (AA 98 to 104 are absent). This sequence differs by 2 nucleotides from K02154 and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(14) Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent).
(15) In frame STOP-CODON (positions 530-532) at codon 90 in FR3-IMGT.
(16) Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 100 to 104 are absent).
(17) No INIT-CODON in L-PART1.
(18) Partial V-REGION: partial FR3-IMGT (AA 100 to 104 are absent).
(19) Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 81 to 104 are absent).
(20) Partial V-REGION: partial FR1-IMGT (AA 1 to 11 are absent).
(21) Sterile transcript.
(22) Sterile transcript, partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 81 to 104 are absent).
(23) In frame STOP-CODON (positions 300-302) at codon 44 in FR2-IMGT.
(24) Partial V-REGION: partial FR1-IMGT (AA 1 to 10 are absent).
(25) In frame STOP-CODON (positions 236-238) at codon 51 in FR2-IMGT, 1st-CYS is replaced by Arg, and INSERTION of 1 nucleotide (g at position 401) in the V-HEPTAMER.
(26) Partial V-REGION: partial FR3-IMGT (AA 93 to 104 are absent), in frame STOP-CODON at codon 51 in FR2-IMGT. This sequence differs by 1 nucleotide from D13202 and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(27) Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent).
(28) Partial V-REGION: partial FR3-IMGT (AA 77 to 104 are absent), no CDR3-IMGT.
(29) INSERTION of 1 nucleotide (c at position 684) in the V-HEPTAMER.
(30) Non canonical V-HEPTAMER: cacattg instead of cacagtg.
(31) No INIT-CODON in L-PART1.
(32) In frame STOP-CODON (positions 375-377) at codon 44 in FR2-IMGT.
(33) This sequence differs by 1 nucleotide from M34983 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(34) No INIT-CODON in the L-PART1, DELETION of 1 nucleotide (between positions 395/396) in FR2-IMGT and non canonical V-HEPTAMER: tacagtg instead of cacagtg.
(35) Partial V-REGION: partial FR3-IMGT (AA 93 to 104 are absent), no CDR3-IMGT..
These sequences were isolated from liver genomic DNA. Most of these sequences are probably germline but some could be from B cells rearranged sequences. In order to assess the level of B lymphocyte contamination in liver, quantative PCR assay was performed. The level of rearranged templates in liver DNA is about one rearranged VH186.2-related gene for every 1000-4000 unrearranged VH186.2-related templates (Rothenfluh in Ph.D thesis) citation in [61]. Based on this observation, the authors consider that their sequences are germline.
(36) DELETION of 1 nucleotide (between positions 787/788) in FR2-IMGT.
(37) In frame STOP-CODON (positions 888-890) at codon 67 in FR3-IMGT.
(38) In frame STOP-CODON (positions 851-853) at codon 54 in FR2-IMGT.
(39) DELETION of 1 nucleotide (between positions 786/787) in FR1-IMGT.
(40) CONSERVED-TRP is replaced by a STOP-CODON.
(41) L26866 and J00535 are mentioned as identical in Weiller et al. [68], the nucleotide t missing between positions 63/64 in L26866 EMBL flat file seems to be a typing error.
(42) This sequence differs by 1 nucleotide from L26858 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(43) This sequence differs by 1 nucleotide from L33936 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(44) DELETION of 1 nucleotide (between positions 838/839) in FR2-IMGT.
(45) In frame STOP-CODON (positions 957-959) at codon 89 in FR3-IMGT, no CDR3-IMGT..
(46) In frame STOP-CODON (positions 793-795) at codon 27 in CDR1-IMGT.
(47) This sequence differs by 1 nucleotide from L26863 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(48) J00502 (761 bp) and M36690 (509 bp) are from the same clone but differ by one nucleotide (g at position 441 in J00502, t at position 188 in M36690) at codon 13 in FR1-IMGT. Comparison with other sequences indicates that the J00502 has the correct sequence.
(49) This sequence differs by 1 nucleotide from X03399 in the V-REGION.
(50) The nucleotide c at position 271 in the EMBL flat file is a typing error because this nucleotide is a g in the manuscript (c271>g in the IMGT unique V-REGION numbering.)
(51) The nucleotide c at position 271 in the EMBL flat file is a typing error because this nucleotide is a g in the manuscript (c271>g in the IMGT unique V-REGION numbering.)
This sequence differs by 1 nucleotide from K02791 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(52) Partial V-REGION: partial FR3-IMGT (AA 92 to 104 are absent), no CDR3-IMGT.
(53) Partial V-REGION: partial FR3-IMGT (AA 102 to 104 are absent), no CDR3-IMGT.
(54) Partial V-REGION: partial FR2-IMGT (AA 1 to 54 are absent).
(55) Partial V-REGION: partial FR1-IMGT (AA 1 to 7 are absent), partial FR3-IMGT (AA 101 to 104 are absent), no CDR3-IMGT.
(56) JUNCTION is out_of_ frame .
(57) These sequences were isolated from liver genomic DNA by PCR using a sense FR1 primer and a FR3 antisense primer. They are probably germline but this needs to be confirmed with a germline sequence.
(58) This sequence differs by 4 nucleotides from K02890 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(59) This sequence differs by 4 nucleotides from X00163 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(60) This sequence differs by 1 nucleotide from X03400 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(61) This sequence differs by 5 nucleotides from X67409 in the V-REGION and is temporarily considered as an allele of this sequence, these data need to be confirmed with a germline sequence.
(62) DELETION of 1 nucleotide (between positions 248/249) in the L-PART2 and in frame STOP-CODON (positions 428-430) at codon 67 in the FR3-IMGT.
(63) Partial V-REGION: partial FR1-IMGT (AA 1 to 12 are absent).
(64) Partial V-REGION: partial FR1-IMGT (AA 1 to 23 are absent).
(65) Partial V-REGION: partial FR1-IMGT (AA 1 to 10 are absent).
(66) Partial V-REGION: partial FR1-IMGT (AA 1 to 24 are absent).
(67) Partial V-REGION: partial CDR2-IMGT and no FR3-IMGT.
(68) Partial V-REGION: partial FR1-IMGT (AA 3 to 5 are absent ), partial FR3-IMGT (AA 67 to 104 are absent).
(69) V00758 is also part of J00538 (positions 443-856) which is a sequence constructed from data of 4 different sources. See note (90).
(70) In frame STOP-CODON (positions 151-153) at codon 52 in FR2-IMGT, STOP-CODON at codon 98 in FR3-IMGT, INSERTION of 4 nucleotides caca (position 281-284) in FR3-IMGT.
(71) The nucleotides c at position 151 and g at position 292 in the J00524 EMBL flat file are typing errors (c151>g and g292>c). The sequences J00500 and J00524 are identical.
(72) This sequence is mentioned as identical to the V3 sequence from Crews et al. [4], in [34], the nucleotide a at position 773 in the M16724 EMBL flat file (instead of g, in J00504 [4]) may represent a typing error.
(73) The nucleotides t at position 140, t at position 144 and a at position 145 in the J00526 EMBL flat file seem to be typing errors (t140>c, t144>a, a145>g).
(74) DELETION of 1 nucleotide (between positions 440/441) in FR2-IMGT and DELETION of 3 nucleotides (between positions 487/488) in CDR2-IMGT.
(75) In frame STOP-CODON at codon 14 in FR1-IMGT, in frame STOP-CODON at codon 106 in CDR3-IMGT, and non canonical V-HEPTAMER: ctcattg instead of cacagtg.
(76) Partial V-REGION: partial FR3-IMGT (AA 103 to 104 are absent), no CDR3-IMGT.
(77) Partial V-REGION: partial FR3-IMGT (AA 103 to 106 are absent), in frame STOP-CODON (positions 146-148) at codon 52 in FR2-IMGT.
(78) Partial V-REGION: partial FR3-IMGT (AA 104 is absent), in frame STOP-CODON at codon 103 in FR3-IMGT.
(79) Partial V-REGION: partial FR3-IMGT (AA 102 to 104 are absent), no CDR3-IMGT..
(80) Partial V-REGION: partial CDR3-IMGT (AA 105 to 106 are absent). This sequence differs by 1 nucleotide from Z15022 and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(81) Partial V-REGION: partial CDR3-IMGT (AA 105 to 106 are absent).
(82) Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent), partial CDR3-IMGT (AA 105 to 106 are absent).
(83) This sequence differs by 2 nucleotides from AF064442 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(84) This sequence differs by 3 nucleotides from AF064443 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
(85) DELETION of 1 nucleotide in the FR1-IMGT leading to a frameshift.
(86) This sequence differs by 1 nucleotide from the putative germline sequence from Chao et al. [50].
(87) This sequence is identical to the putative germline sequence from Chao et al. [50].
(88) INSERTION of 1 bp in FR1-IMGT and INSERTION of 1 bp in FR3-IMGT leading to frameshifts.
(89) JUNCTION is out_of_ frame .
(90) J00538 is a sequence constructed from data of 4 different sources. Positions 443-856 correspond to the germline sequence from V00758. Other parts of the sequence are derived from rearranged clones and need to be confirmed by genomic germline data.
(91) M34984 differs from M34983 by two additional nucleotides (nucleotides ga) at the end of the CDR3-IMGT.
(92) Partial V-REGION: partial FR1-IMGT (AA 1 to 2 are absent), no CDR3-IMGT.
(93) No INIT-CODON in L-PART1.

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Created: 23/03/2001
Last updated: Friday, 27-May-2016 21:01:50 CEST
Author: Christèle Martinez-Jean

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
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Amélie Houles

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