Alignment of alleles: Nurse shark (Ginglymostoma cirratum) IGHW1

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
The Cysteines involved in the IG CH1, CH2 and CH3 intrachain disulfide bridge are shown with a larger letter C in purple. The Cysteines involved in the H-L or H-H interchain disulfide bridge are shown with a larger letter C in black.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

                                       1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                      D   V   Q   V   K   P   S   V   Y   V   S   S   T   S   C   D   T   S   S   N
  U51450  ,IGHW1*01, (CH1) (cDNA)  (G)AT GTC CAG GTC AAA CCT TCA GTT TAT GTT TCC AGT ACT TCC TGT GAC ACA AGC TCC AAT

                                      21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                      Q   D   E   I   S   L   L   C   L   V   K   D   F   Q   P   R   N   I   Q   Q
  U51450  ,IGHW1*01, (CH1) (cDNA)    CAA GAT GAG ATC AGC CTC CTC TGT CTG GTC AAG GAT TTC CAG CCC AGG AAC ATC CAA CAA

                                      41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
                                      T   W   F   S   D   N   K   E   I   T   T   G   F   N   R   Y   P   A   I   L
  U51450  ,IGHW1*01, (CH1) (cDNA)    ACA TGG TTC AGT GAC AAT AAA GAG ATC ACA ACT GGA TTC AAT AGG TAT CCA GCA ATC TTG

                                      61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                      G   Q   N   M   T   Y   T   M   S   S   V   L   S   V   S   A   S   D   W   N
  U51450  ,IGHW1*01, (CH1) (cDNA)    GGG CAA AAT ATG ACG TAC ACA ATG AGC AGT GTG CTC AGT GTC TCT GCA TCG GAT TGG AAT

                                      81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                      A   N   K   V   Y   H   C   K   A   G   Y   K   A   N   E   M   V   E   A   V
  U51450  ,IGHW1*01, (CH1) (cDNA)    GCG AAC AAG GTC TAC CAC TGC AAG GCG GGC TAC AAG GCA AAT GAA ATG GTG GAA GCT GTG

                                     101 102 103 104 105 106 107
                                      V   T   K   P   S   P   P
  U51450  ,IGHW1*01, (CH1) (cDNA)    GTC ACA AAG CCT TCG CCT CCA C



                                       1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                      R   Q   P   Q   S   P   H   V   F   S   V   V   P   S   W   E   M   V   Y   N 
  U51450  ,IGHW1*01, (CH2) (cDNA)     GT CAG CCT CAA TCT CCC CAT GTC TTC TCT GTT GTT CCA TCC TGG GAG ATG GTC TAC AAT

                                      21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                      Q   T   A   A   A   L   G   C   I   L   S   G   F   Y   P   D   S   V   Q   V
  U51450  ,IGHW1*01, (CH2) (cDNA)    CAA ACC GCT GCT GCC CTG GGG TGC ATA CTA TCT GGA TTC TAT CCT GAC AGT GTA CAG GTT

                                      41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
                                      S   W   F   K   A   G   V   P   I   S   Q   S   G   A   K   L   P   S   T   K
  U51450  ,IGHW1*01, (CH2) (cDNA)    TCC TGG TTT AAA GCC GGA GTG CCA ATC TCC CAA TCG GGT GCC AAA CTC CCT TCC ACC AAG

                                      61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                      G   K   G   N   T   F   E   T   V   S   Y   L   T   V   Q   V   A   D   W   K
  U51450  ,IGHW1*01, (CH2) (cDNA)    GGA AAA GGC AAT ACA TTT GAA ACA GTC TCT TAC CTG ACT GTC CAG GTG GCA GAT TGG AAG

                                      81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                      K   G   D   E   Y   T   C   A   V   S   H   E   P   T   S   F   S   T   R   I
  U51450  ,IGHW1*01, (CH2) (cDNA)    AAA GGG GAT GAA TAC ACT TGT GCA GTG TCT CAT GAG CCG ACC AGC TTC AGT ACC AGG ATC

                                     101 102 103 104 105 106
                                      N   M   K   Y   R   E
  U51450  ,IGHW1*01, (CH2) (cDNA)    AAC ATG AAG TAT CGA GAG G



                                       1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                      E   V   S   V   F   L   Q   N   P   S   I   K   E   L   W   I   N   K   T   A
  U51450  ,IGHW1*01, (CH3) (cDNA)     AA GTG TCT GTC TTT CTC CAA AAT CCT TCA ATC AAA GAG CTT TGG ATC AAC AAG ACC GCC

                                      21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                      T   L   V   C   T   A   V   C   S   D   P   S   Q   V   W   I   T   W   K   V
  U51450  ,IGHW1*01, (CH3) (cDNA)    ACC CTG GTG TGT ACA GCA GTC TGT TCT GAT CCC AGC CAG GTC TGG ATC ACC TGG AAG GTG

                                      41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
                                      N   G   R   Q   R   S   K   G   V   T   A   Q   P   Q   R   E   E   G   T   Q
  U51450  ,IGHW1*01, (CH3) (cDNA)    AAT GGG AGG CAG AGA AGT AAA GGG GTT ACA GCT CAG CCA CAG AGA GAG GAA GGC ACC CAA

                                      61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                      Y   I   V   I   S   Q   L   Q   T   T   A   E   E   W   E   S   G   V   E   F
  U51450  ,IGHW1*01, (CH3) (cDNA)    TAC ATC GTC ATC AGC CAA CTC CAA ACC ACA GCA GAG GAG TGG GAG AGT GGA GTG GAG TTT

                                      81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                      V   C   S   A   Q   S   G   P   S   S   S   P   V   S   K   R   T   R   S   L
  U51450  ,IGHW1*01, (CH3) (cDNA)    GTG TGT TCT GCT CAA AGT GGT CCC TCA TCC TCA CCA GTG TCA AAG CGG ACA AGG AGT CTA

                                     101
                                      R
  U51450  ,IGHW1*01, (CH3) (cDNA)    AGA G



                                       1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                      V   P   Q   K   S   P   E   V   R   L   L   P   P   P   A   Q   E   T   E   N 
  U51450  ,IGHW1*01, (CH4) (cDNA)     TT CCG CAA AAA AGT CCC GAG GTC AGA CTG CTG CCT CCA CCA GCC CAA GAG ACC GAG AAT

                                      21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                      Q   S   R   V   T   L   E   C   V   I   T   G   F   Y   P   D   L   I   Q   V
  U51450  ,IGHW1*01, (CH4) (cDNA)    CAG AGC AGA GTT ACA CTC GAG TGT GTA ATC ACT GGA TTC TAC CCA GAC CTC ATA CAG GTC

                                      41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
                                      S   W   E   K   D   S   S   L   I   S   S   N   T   R   A   G   L   T   A   L
  U51450  ,IGHW1*01, (CH4) (cDNA)    TCC TGG GAG AAG GAC AGC AGC CTG ATC TCC TCC AAC ACC CGT GCT GGC CTC ACT GCT CTG

                                      61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                      E   Q   T   G   T   F   S   V   R   H   Y   L   T   V   S   T   E   E   W   R
  U51450  ,IGHW1*01, (CH4) (cDNA)    GAG CAG ACA GGG ACA TTC AGT GTC AGG CAC TAC CTG ACT GTG AGC ACA GAG GAG TGG AGG

                                      81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                      K   G   S   V   F   T   C   A   V   F   H   P   P   S   N   F   A   S   R   K
  U51450  ,IGHW1*01, (CH4) (cDNA)    AAA GGT TCA GTC TTC ACC TGT GCA GTG TTT CAT CCA CCG TCC AAC TTT GCC AGC AGG AAG

                                     101 102 103 104 105 106
                                      E   V   K   N   V   Q
  U51450  ,IGHW1*01, (CH4) (cDNA)    GAG GTG AAG AAT GTC CAA G



                                       1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                      D   E   C   L   D   T   G   I   S   V   T   L   S   K   P   P   F   V   E   I
  U51450  ,IGHW1*01, (CH5) (cDNA)     AT GAA TGC TTG GAC ACT GGA ATC TCG GTC ACC TTA AGC AAG CCT CCA TTT GTA GAG ATC

                                      21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                      W   R   N   R   T   A   T   I   L   C   E   V   L   Y   R   D   L   E   G   V
  U51450  ,IGHW1*01, (CH5) (cDNA)    TGG AGG AAC AGA ACA GCA ACC ATT CTG TGT GAG GTA CTT TAC CGT GAT TTA GAG GGA GTC

                                      41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
                                      R   V   T   W   K   V   D   G   I   M   R   Q   D   G   V   K   T   Q   G   P
  U51450  ,IGHW1*01, (CH5) (cDNA)    AGG GTA ACC TGG AAA GTG GAT GGA ATC ATG AGA CAA GAT GGA GTG AAG ACC CAG GGT CCC

                                      61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                      K   N   C   G   Q   K   E   I   I   L   S   R   L   T   V   P   A   A   E   W
  U51450  ,IGHW1*01, (CH5) (cDNA)    AAG AAC TGT GGA CAA AAA GAG ATC ATC CTC AGT AGA CTG ACG GTC CCT GCT GCA GAA TGG

                                      81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                      E   S   G   V   E   Y   M   C   L   V   E   D   E   N   L   P   I   P   Q   K
  U51450  ,IGHW1*01, (CH5) (cDNA)    GAG AGT GGG GTT GAG TAT ATG TGT TTG GTG GAG GAT GAA AAT TTG CCA ATA CCA CAG AAA

                                     101 102 103 104 105 106 107 
                                      R   F   I   R   K   A   Q   
  U51450  ,IGHW1*01, (CH5) (cDNA)    AGG TTC ATC AGG AAA GCC CAA G



                                       1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                       V   E   V   K   T   H   P   Q   V   Y   L   L   P   P   S   P   D   E   M   E   
  U51450  ,IGHW1*01, (CH6) (cDNA)      TT GAG GTT AAG ACT CAC CCT CAA GTC TAC CTC CTG CCT CCT TCA CCA GAT GAG ATG GAA 

                                      21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                      T   A   H   T   A   T   L   V   C   L   V   T   G   F   S   P   A   D   I   D   
  U51450  ,IGHW1*01, (CH6) (cDNA)    ACT GCT CAT ACT GCG ACC CTG GTT TGC CTG GTC ACT GGA TTC TCT CCC GCA GAT ATC GAC

                                      41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
                                      L   A   W   M   A   S   D   T   L   L   K   T   G   F   I   H   Q   P   V   T   
  U51450  ,IGHW1*01, (CH6) (cDNA)    CTG GCT TGG ATG GCC AGT GAT ACC CTT TTG AAG ACA GGG TTC ATT CAT CAA CCT GTG ACT 

                                      61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                      E   D   G   R   G   G   W   N   S   G   S   R   L   T   V   S   A   E   E   W   
  U51450  ,IGHW1*01, (CH6) (cDNA)    GAG GAT GGC AGA GGA GGC TGG AAC TCG GGC AGT CGC TTG ACA GTC TCT GCA GAG GAG TGG 

                                      81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                      D   S   G   T   T   Y   S   C   V   V   G   H   E   S   V   T   T   N   V   F   
  U51450  ,IGHW1*01, (CH6) (cDNA)    GAC AGC GGC ACC ACG TAC TCC TGT GTG GTG GGA CAC GAG TCA GTC ACA ACA AAT GTG TTC 

                                     101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120
                                      R   S   I   N   K   S   H   S   K   P   N   L   V   N   V   S   L   V   L   T   
  U51450  ,IGHW1*01, (CH6) (cDNA)    AGA AGC ATT AAT AAA TCC CAC AGC AAA CCC AAC CTG GTT AAT GTC TCA CTT GTT CTA ACT 

                                     121 122 123 124 125 126 127
                                      E   S   F   N   S   C   S   *
  U51450  ,IGHW1*01, (CH6) (cDNA)    GAA AGC TTT AAC TCC TGT TCA



This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.


Last updated: Monday, 11-Jul-2011 12:56:59 CEST
Created: 01/07/2002
Author: Dominique Scaviner

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For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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