Alignment of alleles: Nurse shark (Ginglymostoma cirratum) IGHV1S1

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Alignments of alleles are provisory in the absence of the complete germline gene repertoire.

                            1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20 
                           E   I   T   L   I   Q   P   E   A       E   T   G   H   P   G   G   S   L   S                           
   M92851  ,IGHV1S1*01    GAG ATT ACT TTG ATT CAA CCA GAG GCA ... GAG ACC GGC CAT CCT GGA GGC TCC CTG AGT       
          
                                                   ____________________CDR1-IMGT__________________
                           21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                           L   T   C   K   T   R   G   F   N   L   G   S   S   S                   M   Y
   M92851  ,IGHV1S1*01    CTG ACC TGT AAA ACC CGT GGG TTC AAT CTT GGC AGC TCC TCC ... ... ... ... ATG TAT       

                                                                                      ______________ CDR2-
                           41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                           W   I   R   Q   V   P   G   Q   G   L   E   W   I   V   Y   Y   Y   S   S   S        
   M92851  ,IGHV1S1*01    TGG ATC CGA CAG GTT CCC GGA CAG GGG CTG GAG TGG ATA GTT TAC TAC TAT AGT TCT TCG

                          IMGT_______________
                           61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80 
                           M   N               N   Y   A   P   A   I   K       D   R   F   T   A   A   K 
   M92851  ,IGHV1S1*01    ATG AAT ... ... ... AAC TAT GCG CCA GCG ATT AAA ... GAT CGA TTT ACT GCG GCC AAA  


                           81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                           D   T   S   N   N   I   F   A   L   E   M   R   S   V   K   I   D   D   T   A 
   M92851  ,IGHV1S1*01    GAC ACT TCA AAC AAC ATC TTC GCA TTG GAA ATG AGG AGT GTG AAG ATC GAC GAC ACC GCC

                                          _CDR3-IMGT
                          101 102 103 104 105 106
                           I   Y   Y   C   T   R
   M92851  ,IGHV1S1*01    ATC TAT TAC TGT ACA AGA     #c
#c: rearranged cDNA


Created: Monday, 11-Jul-2011 12:56:54 CEST
Authors: Lorena Betancourt and Dominique Scaviner

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