Alignment of alleles: Nurse shark (Ginglymostoma cirratum) IGHV2S38

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Alignments of alleles are provisory in the absence of the complete germline gene repertoire.

                            1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20 
                           V   R   V   D   Q   T   P   Q   T       I   T   K   E   T   G   E   S   L   T  
  U18713  ,IGHV2S38*01    GTT CGA GTG GAC CAA ACA CCG CAA ACA ... ATA ACA AAG GAG ACG GGC GAA TCA CTG ACC 

                                                  ____________________CDR1-IMGT__________________
                           21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                           I   N   C   V   L   R   D   S   N   C   P   L   S   D                   T   S  
  U18713  ,IGHV2S38*01    ATC AAC TGT GTC CTA CGA GAT AGT AAC TGT CCA TTG TCC GAC ... ... ... ... ACG AGC 

                                                                                      ______________ CDR2-
                           41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                           W   Y   R   K   K   S   G   S   T       N   E   E                              
  U18713  ,IGHV2S38*01    TGG TAT CGC AAA AAA TCG GGC TCA ACA ... AAC GAG GAG ... ... ... ... ... ... ... 

                          IMGT_______________
                           61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80 
                                                       S   M   S   K   G       G   R   Y   V   E   T   V  
  U18713  ,IGHV2S38*01    ... ... ... ... ... ... ... AGC ATG TCG AAA GGT ... GGA CGA TAT GTT GAA ACA GTT 


                           81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                           N   S   G   S   K   S   F   S   L   R   I   N   D   L   T   V   E   D   S   G  
  U18713  ,IGHV2S38*01    AAC AGC GGA TCA AAG TCC TTT TCT TTG AGA ATT AAT GAT CTA ACA GTT GAA GAC AGT GGC  

                                          _CDR3-IMGT
                          101 102 103 104 105 106
                           T   Y   R   C   K   L  
  U18713  ,IGHV2S38*01    ACG TAT CGA TGC AAA CTC     #c
#c: rearranged cDNA


Created: Monday, 11-Jul-2011 12:56:54 CEST
Authors: Lorena Betancourt and Dominique Scaviner

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