When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).
Exon names are shown between parentheses on the first line.
The Cysteines involved in the IG CH1, CH2 and CH3 intrachain disulfide bridge are shown with a larger letter C in purple.
The Cysteines involved in the H-L or H-H interchain disulfide bridge are shown with a larger letter C in black.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A S P T S P K V F P L S L D S
J00221 ,IGHA2*01 (CH1) (G)CA TCC CCG ACC AGC CCC AAG GTC TTC CCG CTG AGC CTC GAC AGC
M60192 ,IGHA2*02 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
S71043 ,IGHA2*03 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
T P Q D G N V V V A C L V Q G F
J00221 ,IGHA2*01 (CH1) ACC CCC CAA ... ... ... ... GAT GGG AAC GTG GTC GTC GCA TGC CTG GTC CAG GGC TTC
M60192 ,IGHA2*02 --- --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
S71043 ,IGHA2*03 --- --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
F P Q E P L S V T W S E S G Q N V
J00221 ,IGHA2*01 (CH1) TTC CCC CAG ... GAG CCA CTC AGT GTG ACC TGG AGC GAA AGC GGA CAG AAC GTG ... ...
M60192 ,IGHA2*02 --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
S71043 ,IGHA2*03 --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
T A R N F P P S Q D A S G
J00221 ,IGHA2*01 (CH1) ... ... ACC GCC AGA AAC TTC CCA CCT AGC CAG GAT GCC TCC GGG ... ... ... ... ...
M60192 ,IGHA2*02 ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
S71043 ,IGHA2*03 ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
D L Y T T S S Q L T L P A T Q C P D
J00221 ,IGHA2*01 (CH1) GAC CTG TAC ACC ACG AGC AGC CAG CTG ACC CTG CCG GCC ACA CAG TGC ... ... CCA GAC
M60192 ,IGHA2*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
S71043 ,IGHA2*03 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G K S V T C H V K H Y T N P S Q D
J00221 ,IGHA2*01 (CH1) GGC AAG TCC GTG ACA TGC CAC GTG AAG CAC TAC ... ... ... ACG AAT CCC AGC CAG GAT
S
M60192 ,IGHA2*02 --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- T-- --- --- ---
S
S71043 ,IGHA2*03 --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- T-- --- --- ---
119 120 121 122 123 124
V T V P C P
J00221 ,IGHA2*01 (CH1) GTG ACT GTG CCC TGC CCA G
R
M60192 ,IGHA2*02 --- --- --- --- --- -G- -
R
S71043 ,IGHA2*03 --- --- --- --- --- -G- -
------------------->(1)
1 2 3 4 5 6
V P P P P P
J00221 ,IGHA2*01 (H) (2) TT CCC CCA CCT CCC CCA
M60192 ,IGHA2*02 -- --- --- --- --- ---
S71043 ,IGHA2*03 -- --- --- --- --- ---
1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
C C H P R L S L H R P A L
J00221 ,IGHA2*01 (CH2) TGC TGC CAC CCC CGA CTG TCG CTG CAC CGA CCG GCC CTC
M60192 ,IGHA2*02 --- --- --- --- --- --- --- --- --- --- --- --- ---
AJ012264,IGHA2*02 ---
S71043 ,IGHA2*03 --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E D L L L G S E A N L T C T L T G L
J00221 ,IGHA2*01 (CH2) GAG GAC CTG CTC TTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA CTG ACC GGC CTG
M60192 ,IGHA2*02 --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
AJ012264,IGHA2*02 --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
S71043 ,IGHA2*03 --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
R D A S G A T F T W T P S S G K S
J00221 ,IGHA2*01 (CH2) AGA GAT GCC ... TCT GGT GCC ACC TTC ACC TGG ACG CCC TCA AGT GGG AAG AGC ... ...
M60192 ,IGHA2*02 --- --- --- ... --- --- --- -
AJ012264,IGHA2*02 --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
S71043 ,IGHA2*03 --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
A V Q G P P E R D L C G
J00221 ,IGHA2*01 (CH2) ... ... GCT GTT CAA GGA CCA CCT GAG CGT GAC CTC TGT GGC ... ... ... ... ... ...
AJ012264,IGHA2*02 ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
S71043 ,IGHA2*03 ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
C Y S V S S V L P G C A Q P W N H
J00221 ,IGHA2*01 (CH2) ... TGC TAC AGC GTG TCC AGT GTC CTG CCT GGC TGT GCC CAG CCA TGG ... ... AAC CAT
AJ012264,IGHA2*02 ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
S71043 ,IGHA2*03 ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G E T F T C T A A H P E L K T P L T
J00221 ,IGHA2*01 (CH2) GGG GAG ACC TTC ACC TGC ACT GCT GCC CAC CCC GAG ... ... TTG AAG ACC CCA CTA ACC
AJ012264,IGHA2*02 --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
S71043 ,IGHA2*03 --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
119 120 121 122 123 124
A N I T K S
J00221 ,IGHA2*01 (CH2) GCC AAC ATC ACA AAA TCC G
AJ012264,IGHA2*02 --- --- --- --- --- --- -
S71043 ,IGHA2*03 --- --- --- --- --- --- -
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
G N T F R P E V H L L P P P S
J00221 ,IGHA2*01 (CH3) GA AAC ACA TTC CGG CCC GAG GTC CAC CTG CTG CCG CCG CCG TCG
AJ012264,IGHA2*02 -- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
S71043 ,IGHA2*03 -- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E E L A L N E L V T L T C L A R G F
J00221 ,IGHA2*01 (CH3) GAG GAG CTG GCC CTG ... ... AAC GAG CTG GTG ACG CTG ACG TGC CTG GCA CGT GGC TTC
AJ012264,IGHA2*02 --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
S71043 ,IGHA2*03 --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
S P K D V L V R W L Q G S Q E L P R
J00221 ,IGHA2*01 (CH3) AGC CCC ... ... AAG GAT GTG CTG GTT CGC TGG CTG CAG GGG TCA CAG GAG CTG CCC CGC
AJ012264,IGHA2*02 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
S71043 ,IGHA2*03 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
E K Y L T W A S R Q E P S Q G T
J00221 ,IGHA2*01 (CH3) GAG ... AAG TAC CTG ACT TGG GCA TCC CGG CAG GAG CCC AGC CAG GGC ... ... ... ACC
AJ012264,IGHA2*02 --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ---
S71043 ,IGHA2*03 --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ---
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
T T F A V T S I L R V A A E D W K K
J00221 ,IGHA2*01 (CH3) ACC ACC TTC GCT GTG ACC AGC ATA CTG CGC GTG GCA GCC GAG GAC TGG ... ... AAG AAG
Y
AJ012264,IGHA2*02 --- --- -A- --- --A --- --- --- --- --- --- --- --T --- --- --- ... ... --- ---
S71043 ,IGHA2*03 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G D T F S C M V G H E A L P L A F T Q
J00221 ,IGHA2*01 (CH3) GGG GAC ACC TTC TCC TGC ATG GTG GGC CAC GAG GCC ... CTG CCG CTG GCC TTC ACA CAG
E
AJ012264,IGHA2*02 --- --G --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---
S71043 ,IGHA2*03 --- --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---
____________________________________CHS
119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138
K T I D R L A G K P T H V N V S V
J00221 ,IGHA2*01 (CH3) AAG ACC ATC GAC CGC TTG GCG ... ... ... GGT AAA CCC ACC CAT GTC AAT GTG TCT GTT
M I
AJ012264,IGHA2*02 --- --- --- --- --- A-- --- ... ... ... --- --- --- --- --C A-- --- --- --- ---
S71043 ,IGHA2*03 --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- ---
________________________________________
139 140 141 142 143 144 145 146 147 148
V M A E V D G T C Y *
J00221 ,IGHA2*01 (CH3) GTC ATG GCG GAG GTG GAC GGC ACC TGC TAC
A
AJ012264,IGHA2*02 --- --- --- --- -C- --T --- --- --- ---
S71043 ,IGHA2*03 --- --- --- --- --- --- --- --- --- ---
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
G S C C V A D W Q M P P P Y V V L D L P
M60194 ,IGHA2*02 (M) (G)GC TCT TGC TGT GTT GCA GAT TGG CAG ATG CCG CCT CCC TAT GTG GTG CTG GAC TTG CCG
21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40
Q E T L E E E T P G A N L W P T T I T F
M60194 ,IGHA2*02 (M) CAG GAG ACC CTG GAG GAG GAG ACC CCC GGC GCC AAC CTG TGG CCC ACC ACC ATC ACC TTC
41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60
L T L F L L S L F Y S T A L T V T S V R
M60194 ,IGHA2*02 (M) CTC ACC CTC TTC CTG CTG AGC CTG TTC TAT AGC ACA GCA CTG ACC GTG ACC AGC GTC CGG
61 62 63 64 65 66 67 68 69 70 71
G P S G K R E G P Q Y *
M60194 ,IGHA2*02 (M) GGC CCA TCT GGC AAG AGG GAG GGC CCC CAG TAC
IMGT notes:
| (1) | Arrows show the repetitive unit of the IGHA2 hinge as described in Flanagan, J.G. et al., Cell, 36, 681-688 (1984). |
| (2) | In the IGHA gene, the hinge (H) and the (CH2) are joined in a single exon. |
Created: 20/01/1999
Last updated: Friday, 21-Dec-2012 22:07:21 CET
Authors: Christèle Martinez-Jean and Nathalie Bosc
Contact: Marie-Paule Lefranc
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Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
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