Alignment of alleles: Human
IGHG1
When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
The nucleotide between parentheses at the beginning of exons comes from a
DONOR-SPLICE (n from ngt).
The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).
Exon names are shown between parentheses on the first line.
The Cysteines involved in the IG CH1, CH2 and CH3 intrachain disulfide bridge are shown with a larger letter C in purple.
The Cysteines involved in the H-L or H-H interchain disulfide bridge are shown with a larger letter C in black.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).
Note that Ala 126 (225) (GCA) in Kabat Entry number 013486 is probably a typing error. The corresponding codon in this allele alignment is Val 98 (GTT), which is the last codon of the CH1 exon (and not the first codon of the hinge as shown in Kabat 013486). The IGHG1 Chimpanzee CH1 3' end is therefore identical to the human one, and Figure 3 and Discussion in Ehrlich P.H. et al., Molecular Immunology, 28, 319-322 (1991) should be revised accordingly. Comments added by M.-P. Lefranc on the 16/12/1999, following a question asked by M. Cerutti (France).
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A S T K G P S V F P L A P S S
J00228 ,IGHG1*01 (CH1) (G)CC TCC ACC AAG GGC CCA TCG GTC TTC CCC CTG GCA CCC TCC TCC
Z17370 ,IGHG1*02 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Y14737 ,IGHG1*03,(cDNA) (S) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
JN582178 ,IGHG1*04,(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
K S T S G G T A A L G C L V K D Y
J00228 ,IGHG1*01 (CH1) AAG AGC ACC TCT ... ... ... GGG GGC ACA GCG GCC CTG GGC TGC CTG GTC AAG GAC TAC
Z17370 ,IGHG1*02 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
F P E P V T V S W N S G A L T S
J00228 ,IGHG1*01 (CH1) TTC CCC ... ... GAA CCG GTG ACG GTG TCG TGG AAC TCA GGC GCC CTG ACC AGC ... ...
Z17370 ,IGHG1*02 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
Y14737 ,IGHG1*03,(cDNA) (S) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
JN582178 ,IGHG1*04,(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
G V H T F P A V L Q S S
J00228 ,IGHG1*01 (CH1) ... ... GGC GTG CAC ACC TTC CCG GCT GTC CTA CAG TCC TCA ... ... ... ... ... ...
Z17370 ,IGHG1*02 ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
Y14737 ,IGHG1*03,(cDNA) (S) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
JN582178 ,IGHG1*04,(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
G L Y S L S S V V T V P S S S L G
J00228 ,IGHG1*01 (CH1) GGA CTC TAC TCC CTC AGC AGC GTG GTG ACC GTG CCC TCC AGC AGC TTG ... ... ... GGC
Z17370 ,IGHG1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
T Q T Y I C N V N H K P S N T K V D
J00228 ,IGHG1*01 (CH1) ACC CAG ACC TAC ATC TGC AAC GTG AAT CAC AAG CCC ... ... AGC AAC ACC AAG GTG GAC
Z17370 ,IGHG1*02 --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
119 120 121
K K V
J00228 ,IGHG1*01 (CH1) AAG AAA GTT G
Z17370 ,IGHG1*02 --- --- --- -
R
Y14737 ,IGHG1*03,(cDNA) (S) --- -G- --- -
JN582178 ,IGHG1*04,(cDNA) --- --- --- -
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
E P K S C D K T H T C P P C P
J00228 ,IGHG1*01 (H) AG CCC AAA TCT TGT GAC AAA ACT CAC ACA TGC CCA CCG TGC CCA G
Z17370 ,IGHG1*02 -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -
Y14737 ,IGHG1*03,(cDNA) (S) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -
JN582178 ,IGHG1*04,(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -
1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A P E L L G G P S V F L F P P K P
J00228 ,IGHG1*01 (CH2) CA CCT GAA CTC CTG GGG GGA CCG TCA GTC TTC CTC TTC CCC CCA AAA CCC
Z17370 ,IGHG1*02 -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Y14737 ,IGHG1*03,(cDNA) (S) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
JN582178 ,IGHG1*04,(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
K D T L M I S R T P E V T C V V V D V
J00228 ,IGHG1*01 (CH2) AAG GAC ACC CTC ATG ATC ... TCC CGG ACC CCT GAG GTC ACA TGC GTG GTG GTG GAC GTG
Z17370 ,IGHG1*02 --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
S H E D P E V K F N W Y V D G V E V H
J00228 ,IGHG1*01 (CH2) AGC CAC GAA GAC CCT GAG GTC AAG TTC AAC TGG TAC GTG GAC GGC GTG GAG GTG CAT ...
Z17370 ,IGHG1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
N A K T K P R E E Q Y N
J00228 ,IGHG1*01 (CH2) ... ... AAT GCC AAG ACA AAG CCG CGG GAG GAG CAG TAC AAC ... ... ... ... ... ...
Z17370 ,IGHG1*02 ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
Y14737 ,IGHG1*03,(cDNA) (S) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
JN582178 ,IGHG1*04,(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
S T Y R V V S V L T V L H Q D W L N
J00228 ,IGHG1*01 (CH2) AGC ACG TAC CGG GTG GTC AGC GTC CTC ACC GTC CTG CAC CAG GAC TGG ... ... CTG AAT
Z17370 ,IGHG1*02 --- --- --- --T --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --T --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --T --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G K E Y K C K V S N K A L P A P I E
J00228 ,IGHG1*01 (CH2) GGC AAG GAG TAC AAG TGC AAG GTC TCC AAC AAA GCC ... ... CTC CCA GCC CCC ATC GAG
Z17370 ,IGHG1*02 --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
119 120 121 122 123 124 125
K T I S K A K
J00228 ,IGHG1*01 (CH2) AAA ACC ATC TCC AAA GCC AAA G
Z17370 ,IGHG1*02 --- --- --- --- --- --- --- -
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --- --- -
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- --- --- --- -
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
G Q P R E P Q V Y T L P P S R
J00228 ,IGHG1*01 (CH3) GG CAG CCC CGA GAA CCA CAG GTG TAC ACC CTG CCC CCA TCC CGG
Z17370 ,IGHG1*02 -- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Y14737 ,IGHG1*03,(cDNA) (S) -- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
JN582178 ,IGHG1*04,(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
D E L T K N Q V S L T C L V K G F
J00228 ,IGHG1*01 (CH3) GAT GAG CTG ACC ... ... ... AAG AAC CAG GTC AGC CTG ACC TGC CTG GTC AAA GGC TTC
Z17370 ,IGHG1*02 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
E M
Y14737 ,IGHG1*03,(cDNA) (S) --G --- A-- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
Y P S D I A V E W E S N G Q P E N
J00228 ,IGHG1*01 (CH3) TAT CCC ... ... AGC GAC ATC GCC GTG GAG TGG GAG AGC AAT GGG CAG CCG GAG AAC ...
Z17370 ,IGHG1*02 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
Y14737 ,IGHG1*03,(cDNA) (S) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
JN582178 ,IGHG1*04,(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
N Y K T T P P V L D S D
J00228 ,IGHG1*01 (CH3) ... ... AAC TAC AAG ACC ACG CCT CCC GTG CTG GAC TCC GAC ... ... ... ... ... ...
Z17370 ,IGHG1*02 ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
Y14737 ,IGHG1*03,(cDNA) (S) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
JN582178 ,IGHG1*04,(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
G S F F L Y S K L T V D K S R W Q Q
J00228 ,IGHG1*01 (CH3) GGC TCC TTC TTC CTC TAC AGC AAG CTC ACC GTG GAC AAG AGC AGG TGG ... ... CAG CAG
Z17370 ,IGHG1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --T --- --- --- --- --- --- --- --- --- --- ... ... --- ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G N V F S C S V M H E A L H N H Y T Q
J00228 ,IGHG1*01 (CH3) GGG AAC GTC TTC TCA TGC TCC GTG ATG CAT GAG GCT ... CTG CAC AAC CAC TAC ACG CAG
Z17370 ,IGHG1*02 --- --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---
I
JN582178 ,IGHG1*04,(cDNA) --- --- A-- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---
CHS___
119 120 121 122 123 124 125 126 127 128 129 130
K S L S L S P G K *
J00228 ,IGHG1*01 (CH3) AAG AGC CTC TCC CTG TCT CCG ... ... ... GGT AAA
Z17370 ,IGHG1*02 --- --- --- --- --- --- --- ... ... ... --- ---
Y14737 ,IGHG1*03,(cDNA) (S) --- --- --- --- --- --C --- ... ... ... --- ---
JN582178 ,IGHG1*04,(cDNA) --- --- --- --- --- --- --- ... ... ... --- ---
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
E L Q L E E S C A E A Q D G E L D G L W
X52847 ,IGHG1*01,(cDNA) (m) (M1)(G)AG CTG CAA CTG GAG GAG AGC TGT GCG GAG GCG CAG GAC GGG GAG CTG GAC GGG CTG TGG
21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40
T T I T I F I T L F L L S V C Y S A T V
X52847 ,IGHG1*01,(cDNA) (m) (M1) ACG ACC ATC ACC ATC TTC ATC ACA CTC TTC CTG TTA AGC GTG TGC TAC AGT GCC ACC GTC
41 42 43 44
T F F K
X52847 ,IGHG1*01,(cDNA) (m) (M1) ACC TTC TTC AAG
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
V K W I F S S V V D L K Q T I I P D Y R
X52847 ,IGHG1*01,(cDNA) (m) (M2) GTG AAG TGG ATC TTC TCC TCG GTG GTG GAC CTG AAG CAG ACC ATC ATC CCC GAC TAC AGG
21 22 23 24 25 26 27
N M I G Q G A *
X52847 ,IGHG1*01,(cDNA) (m) (M2) AAC ATG ATC GGA CAG GGG GCC
(s): transcript of a secreted chain
(m): transcript of a membrane chain
This alignment has been generated with the IMGT/AlleleAlign tool developed by Mehdi Yousfi (31/07/2001)
Created: 20/01/1999
Last updated: Friday, 21-Dec-2012 22:07:21 CET
Authors: Joumana Jabado-Michaloud, Christèle Martinez-Jean and Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only,
provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics
information system® http://www.imgt.org
(founder and director: Marie-Paule Lefranc, Montpellier, France)."
References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
