When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.
IMGT notes:
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
(R) T V A A P S V F I F P P S D
J00241 ,IGKC*01 (C)GA ACT GTG GCT GCA CCA TCT GTC TTC ATC TTC CCG CCA TCT GAT
X67858 ,IGKC*01 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
U72063 ,IGKC*01 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X96754 ,IGKC*01 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
M11736 ,IGKC*02 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
M11737 ,IGKC*03 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AF017732,IGKC*04 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AF113887,IGKC*05 (cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E Q L K S G T A S V V C L L N N F
J00241 ,IGKC*01 GAG CAG TTG AAA ... ... ... TCT GGA ACT GCC TCT GTT GTG TGC CTG CTG AAT AAC TTC
X67858 ,IGKC*01 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
U72063 ,IGKC*01 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
X96754 ,IGKC*01 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
M11736 ,IGKC*02 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
M11737 ,IGKC*03 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
AF017732,IGKC*04 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
AF113887,IGKC*05 (cDNA) --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
Y P R E A K V Q W K V D N A L Q S G
J00241 ,IGKC*01 TAT CCC ... ... AGA GAG GCC AAA GTA CAG TGG AAG GTG GAT AAC GCC CTC CAA TCG GGT
X67858 ,IGKC*01 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
U72063 ,IGKC*01 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X96754 ,IGKC*01 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
M11736 ,IGKC*02 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
R
M11737 ,IGKC*03 --- --- ... ... --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- ---
AF017732,IGKC*04 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AF113887,IGKC*05 (cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
N S Q E S V T E Q D S K D
J00241 ,IGKC*01 (CH1) ... ... AAC TCC CAG GAG AGT GTC ACA GAG CAG GAC AGC AAG GAC ... ... ... ... ...
X67858 ,IGKC*01 ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
U72063 ,IGKC*01 ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
X96754 ,IGKC*01 ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
E
M11736 ,IGKC*02 ... ... --- --- --- --- --- --- --- --- --- --G --- --- --- ... ... ... ... ...
E
M11737 ,IGKC*03 ... ... --- --- --- --- --- --- --- --- --- --G --- --- --- ... ... ... ... ...
AF017732,IGKC*04 ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
AF113887,IGKC*05 (cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
S T Y S L S S T L T L S K A D Y E K
J00241 ,IGKC*01 AGC ACC TAC AGC CTC AGC AGC ACC CTG ACG CTG AGC AAA GCA GAC TAC ... ... GAG AAA
X67858 ,IGKC*01 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
U72063 ,IGKC*01 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
X96754 ,IGKC*01 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
M11736 ,IGKC*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
M11737 ,IGKC*03 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
AF017732,IGKC*04 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
N
AF113887,IGKC*05 (cDNA) --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- ... ... --- ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
H K V Y A C E V T H Q G L S S P V T
J00241 ,IGKC*01 CAC AAA GTC TAC GCC TGC GAA GTC ACC CAT CAG GGC ... ... CTG AGC TCG CCC GTC ACA
X67858 ,IGKC*01 --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
U72063 ,IGKC*01 --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
X96754 ,IGKC*01 --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
G
M11736 ,IGKC*02 --- --- --- --- --- G-- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
M11737 ,IGKC*03 --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
L
AF017732,IGKC*04 --- --- C-- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
AF113887,IGKC*05 (cDNA) --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
119 120 121 122 123 124 125 126
K S F N R G E C *
J00241 ,IGKC*01 AAG AGC TTC AAC AGG GGA GAG TGT
X67858 ,IGKC*01 --- --- --- --- --- --- --- ---
U72063 ,IGKC*01 --- --- --- --- --- --- --- ---
X96754 ,IGKC*01 --- --- --- --- --- --- --- ---
M11736 ,IGKC*02 --- --- --- --- --- --- --- ---
M11737 ,IGKC*03 --- --- --- --- --- --- --- ---
AF017732,IGKC*04 --- --- --- --- --- --- --- ---
AF113887,IGKC*05 (cDNA) --- --- --- --- --- --- --- --C
IGKC*06 (not sequenced at the nucleotide level and therefore not reported here) corresponds to Km1 allele and has amino changes A45.1>V and V101>L. The expected codons are gtc (V45.1) and ctc (L101), respectively (G.Lefranc and M.-P.Lefranc,13/05/2003).
Created: 18/04/2001
Last updated: Tuesday, 03-Apr-2012 08:20:22 CEST
Author: Delphine Guiraudou
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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Marie-Paule.Lefranc@igh.cnrs.fr
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