When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
Click here to see Correspondence between serological lambda isotypes and IGLC gene and alleles names.
1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
P K A A P S V T L F P P S S
J00254 ,IGLC3*01, Ke-Oz+ CCC AAG GCT GCC CCC TCG GTC ACT CTG TTC CCA CCC TCC TCT
G Q
K01326 ,IGLC3*02 (G)GT CAG --- --- --- --- --- --- --- --- --- --- --- --- --- ---
G Q
X06876 ,IGLC3*03 (G)GT CAG --- --- --- --- --- --- --- --- --- --- --- --- --- ---
G Q
X51755 ,IGLC3*03 (G)GT CAG --- --- --- --- --- --- --- --- --- --- --- --- --- ---
G Q
D87017 ,IGLC3*04, Ke-Oz- (G)GT CAG --- --- --- --- --- --- --- --- --- --- --G --- --- ---
G Q
D87023 ,IGLC3*04 (G)GT CAG --- --- --- --- --- --- --- --- --- --- --G --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E E L Q A N K A T L V C L I S D F
J00254 ,IGLC3*01, Ke-Oz+ GAG GAG CTT CAA ... ... ... GCC AAC AAG GCC ACA CTG GTG TGT CTC ATA AGT GAC TTC
K01326 ,IGLC3*02 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
X06876 ,IGLC3*03 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
X51755 ,IGLC3*03 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
D87017 ,IGLC3*04, Ke-Oz- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
D87023 ,IGLC3*04 --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
Y P G A V T V A W K A D S S P V K A
J00254 ,IGLC3*01, Ke-Oz+ TAC CCG ... ... GGA GCC GTG ACA GTT GCC TGG AAG GCA GAT AGC AGC CCC GTC AAG GCG
P
K01326 ,IGLC3*02 (1) --- --- ... ... --G C-A --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X06876 ,IGLC3*03 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X51755 ,IGLC3*03 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
D87017 ,IGLC3*04, Ke-Oz- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
D87023 ,IGLC3*04 --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
G V E T T T P S K Q S N
J00254 ,IGLC3*01, Ke-Oz+ ... ... GGG GTG GAG ACC ACC ACA CCC TCC AAA CAA AGC AAC ... ... ... ... ... ...
K01326 ,IGLC3*02 ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
X06876 ,IGLC3*03 ... ... --A --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
X51755 ,IGLC3*03 ... ... --A --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
D87017 ,IGLC3*04, Ke-Oz- ... ... --A --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
D87023 ,IGLC3*04 ... ... --A --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
N K Y A A S S Y L S L T P E Q W K S
J00254 ,IGLC3*01, Ke-Oz+ AAC AAG TAC GCG GCC AGC AGC TAC CTG AGC CTG ACG CCT GAG CAG TGG ... ... AAG TCC
K01326 ,IGLC3*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
X06876 ,IGLC3*03 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
X51755 ,IGLC3*03 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
D87017 ,IGLC3*04, Ke-Oz- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
D87023 ,IGLC3*04 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
H K S Y S C Q V T H E G S T V E
J00254 ,IGLC3*01, Ke-Oz+ CAC AAA AGC TAC AGC TGC CAG GTC ACG CAT GAA ... ... ... ... GGG AGC ACC GTG GAG
K01326 ,IGLC3*02 --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- ---
X06876 ,IGLC3*03 --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- ---
X51755 ,IGLC3*03 --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- ---
R
D87017 ,IGLC3*04, Ke-Oz- (2) --- -G- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- ---
R
D87023 ,IGLC3*04 (2) --- -G- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- ---
119 120 121 122 123 124 125 126 127
K T V A P T E C S *
J00254 ,IGLC3*01, Ke-Oz+ AAG ACA GTT GCC CCT ACG GAA TGT TCA
K01326 ,IGLC3*02 --- --- --G --- --- --- --- --- ---
X06876 ,IGLC3*03 --- --- --G --- --- --A --- --- ---
X51755 ,IGLC3*03 --- --- --G --- --- --A --- --- ---
D87017 ,IGLC3*04, Ke-Oz- --- --- --G --- --- --A --- --- ---
D87023 ,IGLC3*04 --- --- --G --- --- --A --- --- ---
IMGT notes:
| (1) | The sequence GCCA instead of AGCC may be a typing or sequencing error and needs to be confirmed by other data. |
| (2) | The IGLC3 Ke- Oz- isotype has not been assigned serologically but on the presence of the Arg83. |
This alignment has been generated with the IMGT/AlleleAlign tool developed by Mehdi Yousfi (31/07/2001)
Created: 06/11/2002
Author: Delphine Guiraudou
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
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