Alignment of alleles: Human TRBC1

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

                                                                                                               
                                        1.7 1.6 1.5 1.4 1.3 1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                         E   D   L   N   K   V   F   P   P   E   V   A   V   F   E   P   S   E 
  M12887       ,TRBC1*01 (EX1)        (G)AG GAC CTG AAC AAG GTG TTC CCA CCC GAG GTC GCT GTG TTT GAG CCA TCA GAA
                                                                                                               
  M14157       ,TRBC1*01              (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  L36092/U66061,TRBC1*02 (1)          (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 A   E   I   S   H           T   Q   K   A   T   L   V   C   L   A   T   G   F 
  M12887       ,TRBC1*01 (EX1)  GCA GAG ATC TCC CAC ... ... ACC CAA AAG GCC ACA CTG GTG TGC CTG GCC ACA GGC TTC
                                                                                                               
  M14157       ,TRBC1*01        --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  L36092/U66061,TRBC1*02 (1)    --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---

                                _________BC_____________________                            ___________CD_______
                                                                                           45.1    45.3    45.5
                                 29  30  31  32  33  34  35  36  39  40  41  42  43  44  45    45.2    45.4    
                                 F   P           D   H   V   E   L   S   W   W   V   N   G   K   E   V   H   S 
  M12887       ,TRBC1*01 (EX1)  TTC CCC ... ... GAC CAC GTG GAG CTG AGC TGG TGG GTG AAT GGG AAG GAG GTG CAC AGT
                                                                                                               
  M14157       ,TRBC1*01        --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  L36092/U66061,TRBC1*02 (1)    --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                ________                                _________________________DE_____________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    
                               45.6      77  78  79  80  81  82  83  84    84.2    84.4    84.6    85.7    85.5
                                         G   V   S   T   D   P   Q   P   L   K   E   Q   P   A   L       N   D 
  M12887       ,TRBC1*01 (EX1)  ... ... GGG GTC AGC ACG GAC CCG CAG CCC CTC AAG GAG CAG CCC GCC CTC ... AAT GAC

  M14157       ,TRBC1*01        ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... --- ---
                                                                                                               
  L36092/U66061,TRBC1*02 (1)    ... ... --- --- --- --A --- --- --- --- --- --- --- --- --- --- --- ... --- ---

                                ________________                                                _EF_____        
                               85.4    85.2                                                    96.1            
                                   85.3    85.1  85  86  87  88  89  90  91  92  93  94  95  96    96.2  97  98
                                 S   R   Y   C   L   S   S   R   L   R   V   S   A   T   F   W   Q       N   P 
  M12887       ,TRBC1*01 (EX1)  TCC AGA TAC TGC CTG AGC AGC CGC CTG AGG GTC TCG GCC ACC TTC TGG CAG ... AAC CCC
                                                                                                               
  M14157       ,TRBC1*01        --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... --- ---
                                                                                                               
  L36092/U66061,TRBC1*02 (1)    --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... --- ---

                                                        _______________________________________________FG_______
                                                                                  111.1   111.3   111.5   112.6
                                 99 100 101 102 103 104 105 106 107 108 109 110 111   111.2   111.4   111.6
                                 R   N   H   F   R   C   Q   V   Q   F   Y   G   L   S   E   N   D   E   W   T 
  M12887       ,TRBC1*01 (EX1)  CGC AAC CAC TTC CGC TGT CAA GTC CAG TTC TAC GGG CTC TCG GAG AAT GAC GAG TGG ACC
                                                                                                               
  M14157       ,TRBC1*01        --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  L36092/U66061,TRBC1*02 (1)    --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                              _____________________________________________                                    
                                  112.4   112.2                                                           
                              112.5   112.3   112.1 112 113 114 115 116 117 118 119 120 121 122 123 124 125
                                 Q   D   R   A   K   P   V   T   Q   I   V   S   A   E   A   W   G   R   A  
  M12887       ,TRBC1*01 (EX1)  CAG GAT AGG GCC AAA CCC GTC ACC CAG ATC GTC AGC GCC GAG GCC TGG GGT AGA GCA G
                                                                                                            
  M14157       ,TRBC1*01        --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -
                                                                                                            
  L36092/U66061,TRBC1*02 (1)    --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -



                                  1   2   3   4   5   6
                                 D   C   G   F   T   S  
  M12887       ,TRBC1*01 (EX2)   AC TGT GGC TTT ACC TCG G
                                                        
  M14157       ,TRBC1*01         -- --- --- --- --- --- -
                                                        
  L36092/U66061,TRBC1*02 (1)     -- --- --- --- --- --- -



                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 V   S   Y   Q   Q   G   V   L   S   A   T   I   L   Y   E   I   L   L   G   K 
  M12887       ,TRBC1*01 (EX3)   TG TCC TAC CAG CAA GGG GTC CTG TCT GCC ACC ATC CTC TAT GAG ATC CTG CTA GGG AAG
                                                                                                               
  M14157       ,TRBC1*01         -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  L36092/U66061,TRBC1*02 (1)     -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36
                                 A   T   L   Y   A   V   L   V   S   A   L   V   L   M   A   M  
  M12887       ,TRBC1*01 (EX3)  GCC ACC CTG TAT GCT GTG CTG GTC AGC GCC CTT GTG TTG ATG GCC ATG 
                                                                                                
  M14157       ,TRBC1*01        --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                                
  L36092/U66061,TRBC1*02 (1)    --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 



                                  1   2   3   4   5   6
                                 V   K   R   K   D   F   *  
  M12887       ,TRBC1*01 (EX4)  GTC AAG AGA AAG GAT TTC 
                                                        
  M14157       ,TRBC1*01        --- --- --- --- --- --- 
                                                        
  L36092/U66061,TRBC1*02 (1)    --- --- --- --- --- --- 


IMGT note:
(1) The original L36092 sequence (684973 bp) has been split in EMBL into three sequences of 267156 bp (U66059), 215422 bp (U66060) and 232650 bp (U66061), L36092 has become secondary accession number of U66059, U66060 and U66061.
In IMGT, the original sequence L36092 which is fully annotated has also been kept as primary accession number, in addition to U66059, U66060 and U66061.


This alignement has been generated with the IMGT/AlleleAlign tool developed by Mehdi Yousfi (31/07/2001)

Created: 04/08/1999
Last updated: Tuesday, 03-Apr-2012 08:20:22 CEST
Authors: Géraldine Folch and Nathalie Bosc

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For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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