When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.

Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Exon names are shown between parentheses on the first line.

Cysteine involved in the disulfide bridge are shown in purple.

STOP-CODON is indicated by an asterisk.

1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 D K Q L D A D V S P K P T I F L P S I M15002 ,TRGC2*01(2X) (EX1) (G)AT AAA CAA CTT GAT GCA GAT GTT TCC CCC AAG CCC ACT ATT TTT CTT CCT TCA ATT M13231 ,TRGC2*01(2X),(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M15001 ,TRGC2*02(2X) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- BC017861,TRGC2*02(2X),(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- M17324 ,TRGC2*03(2X),(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- AF159056,TRGC2*04(2X) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M17323 ,TRGC2*05(3X),(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- M30894 ,TRGC2*05(3X),(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- Y00790 ,TRGC2*06(2X),(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- M27331 ,TRGC2*07(2X),(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M27332 ,TRGC2*08(2X),(cDNA) (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --G --- ___AB_______ ________ 15.1 15.3 12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 A E T K L Q K A G T Y LCL L E K F M15002 ,TRGC2*01(2X) (EX1) GCT GAA ACA AAA CTC ... ... CAG AAG GCT GGA ACA TAC CTT TGT CTT CTT GAG AAA TTT M13231 ,TRGC2*01(2X),(cDNA) --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- M15001 ,TRGC2*02(2X) --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- BC017861,TRGC2*02(2X),(cDNA) --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- M17324 ,TRGC2*03(2X),(cDNA) --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- AF159056,TRGC2*04(2X) --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- M17323 ,TRGC2*05(3X),(cDNA) --- --- --- --- --- ... ... --- --- --- --- --- --T --- --- --- --- --- --- --- M30894 ,TRGC2*05(3X),(cDNA) --- --- --- --- --- ... ... --- --- --- --- --- --T --- --- --- --- --- --- --- Y00790 ,TRGC2*06(2X),(cDNA) --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- M27331 ,TRGC2*07(2X),(cDNA) --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- M27332 ,TRGC2*08(2X),(cDNA) --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- _________BC_____________________ ___________CD_______ 45.1 45.3 45.5 29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4 F P D I I K I H W Q E K K S N T I L M15002 ,TRGC2*01(2X) (EX1) TTC CCA ... ... GAT ATT ATT AAG ATA CAT TGG CAA GAA AAG AAG AGC AAC ACG ATT CTG M13231 ,TRGC2*01(2X),(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M15001 ,TRGC2*02(2X) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- BC017861,TRGC2*02(2X),(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M17324 ,TRGC2*03(2X),(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AF159056,TRGC2*04(2X) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M17323 ,TRGC2*05(3X),(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M30894 ,TRGC2*05(3X),(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- Y00790 ,TRGC2*06(2X),(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M27331 ,TRGC2*07(2X),(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M27332 ,TRGC2*08(2X),(cDNA) --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ________ _________________________DE_____________ 45.7 84.1 84.3 84.5 84.7 85.6 45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5 G S Q E G N T M K T N D M15002 ,TRGC2*01(2X) (EX1) ... ... GGA TCC CAG GAG GGG AAC ACC ATG AAG ACT AAC GAC ... ... ... ... ... ... M13231 ,TRGC2*01(2X),(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... M15001 ,TRGC2*02(2X) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... BC017861,TRGC2*02(2X),(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... M17324 ,TRGC2*03(2X),(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... AF159056,TRGC2*04(2X) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... M17323 ,TRGC2*05(3X),(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... M30894 ,TRGC2*05(3X),(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... Y00790 ,TRGC2*06(2X),(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... M27331 ,TRGC2*07(2X),(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... M27332 ,TRGC2*08(2X),(cDNA) ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ________________ _EF_____ 85.4 85.2 96.1 85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 T Y M K F S W L T V P E E S L M15002 ,TRGC2*01(2X) (EX1) ... ACA TAC ATG AAA TTT AGC TGG TTA ACG GTG CCA GAA GAG ... ... ... ... TCA CTG M13231 ,TRGC2*01(2X),(cDNA) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- M15001 ,TRGC2*02(2X) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- BC017861,TRGC2*02(2X),(cDNA) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- M17324 ,TRGC2*03(2X),(cDNA) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- AF159056,TRGC2*04(2X) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- M17323 ,TRGC2*05(3X),(cDNA) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- M30894 ,TRGC2*05(3X),(cDNA) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- Y00790 ,TRGC2*06(2X),(cDNA) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- M27331 ,TRGC2*07(2X),(cDNA) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- M27332 ,TRGC2*08(2X),(cDNA) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- _______________________FG___________________________ 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 D K E H RCI V R H E N N K N G I D Q E M15002 ,TRGC2*01(2X) (EX1) GAC AAA GAA CAC AGA TGT ATC GTC AGA CAT GAG AAT AAT AAA AAC GGA ATT GAT CAA GAA M13231 ,TRGC2*01(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M15001 ,TRGC2*02(2X) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- BC017861,TRGC2*02(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M17324 ,TRGC2*03(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AF159056,TRGC2*04(2X) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M17323 ,TRGC2*05(3X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M30894 ,TRGC2*05(3X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- Y00790 ,TRGC2*06(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M27331 ,TRGC2*07(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M27332 ,TRGC2*08(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 119 120 121 122 123 124 125 126 I I F P P I K T M15002 ,TRGC2*01(2X) (EX1) ATT ATC TTT CCT CCA ATA AAG ACA G M13231 ,TRGC2*01(2X),(cDNA) --- --- --- --- --- --- --- --- - M15001 ,TRGC2*02(2X) --- --- --- --- --- --- --- --- - BC017861,TRGC2*02(2X),(cDNA) --- --- --- --- --- --- --- --- - M17324 ,TRGC2*03(2X),(cDNA) --- --- --- --- --- --- --- --- - AF159056,TRGC2*04(2X) --- --- --- --- --- --- --- --- - M17323 ,TRGC2*05(3X),(cDNA) --- --- --- --- --- --- --- --- - M30894 ,TRGC2*05(3X),(cDNA) --- --- --- --- --- --- --- --- - Y00790 ,TRGC2*06(2X),(cDNA) --- --- --- --- --- --- --- --- - M27331 ,TRGC2*07(2X),(cDNA) --- --- --- --- --- --- --- --- - M27332 ,TRGC2*08(2X),(cDNA) --- --- --- --- --- --- --- --- - 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 D V T T V D P K D S Y S K D A N M13231 ,TRGC2*01(2X) (EX2T) AT GTC ACC ACA GTG GAT CCC AAA GAC AGT TAT TCA AAA GAT GCA AAT G Y N M15004 ,TRGC2*02(2X) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - Y N BC017861,TRGC2*02(2X),(cDNA) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - Y N M17324 ,TRGC2*03(2X),(cDNA) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - Y N AF159056,TRGC2*04(2X) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - M25318 ,TRGC2*05(3X) (EX2T) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - M17323 ,TRGC2*05(3X),(cDNA) (EX2T) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - M30894 ,TRGC2*05(3X),(cDNA) (EX2T) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - Y N M17323 ,TRGC2*05(3X),(cDNA) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - Y N M30894 ,TRGC2*05(3X),(cDNA) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - Y N Y00790 ,TRGC2*06(2X),(cDNA) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - Y N M27331 ,TRGC2*07(2X),(cDNA) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - Y N M27332 ,TRGC2*08(2X),(cDNA) (EX2R) -- --- --- --- --- --- --- --- T-- -A- --- --- --G --- --- --- - 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 D V I T M D P K DN W SK D A N M13231 ,TRGC2*01(2X) (EX2) AT GTC ATC ACA ATG GAT CCC AAA GAC AAT TGG TCA AAA GAT GCA AAT G M15005 ,TRGC2*02(2X) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - BC017861,TRGC2*02(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - I M17324 ,TRGC2*03(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- - I AF159056,TRGC2*04(2X) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -T- - M17323 ,TRGC2*05(3X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - M30894 ,TRGC2*05(3X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - Y00790 ,TRGC2*06(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - M27331 ,TRGC2*07(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - M27332 ,TRGC2*08(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- - 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 D T L L L Q L TN T SA Y Y M Y L L L L M13231 ,TRGC2*01(2X) (EX3) AT ACA CTA CTG CTG CAG CTC ACA AAC ACC TCT GCA TAT TAC ATG TAC CTC CTC CTG CTC M15007 ,TRGC2*02(2X) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- BC017861,TRGC2*02(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M17324 ,TRGC2*03(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AF159056,TRGC2*04(2X) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M17323 ,TRGC2*05(3X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- T Y00790 ,TRGC2*06(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- -C- --- --- --- --- --- M27331 ,TRGC2*07(2X),(cDNA) -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M27332 ,TRGC2*08(2X),(cDNA) -- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 L K S V V Y F A I I T C C L L G R T A F M13231 ,TRGC2*01(2X) (EX3) CTC AAG AGT GTG GTC TAT TTT GCC ATC ATC ACC TGC TGT CTG CTT GGA AGA ACG GCT TTC M15007 ,TRGC2*02(2X) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- BC017861,TRGC2*02(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- G R M17324 ,TRGC2*03(2X),(cDNA) --- --- --- -GT --- --- --- --- --- --- --- --- --- --- --- A-- --- --- --- --- AF159056,TRGC2*04(2X) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M17323 ,TRGC2*05(3X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- R Y00790 ,TRGC2*06(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- A-- --- --- --- --- M27331 ,TRGC2*07(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- M27332 ,TRGC2*08(2X),(cDNA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 41 42 43 44 45 46 47 C C N G E K S * M13231 ,TRGC2*01(2X) (EX3) TGC TGC AAT GGA GAG AAA TCA M15007 ,TRGC2*02(2X) --- --- --- --- --- --- --- BC017861,TRGC2*02(2X),(cDNA) --- --- --- --- --- --- --- M17324 ,TRGC2*03(2X),(cDNA) --- --- --- --- --- --- --- AF159056,TRGC2*04(2X) --- --- --- --- --- --- --- M17323 ,TRGC2*05(3X),(cDNA) --- --- --- --- --- --- --- Y00790 ,TRGC2*06(2X),(cDNA) --- --- --- --- --- --- --- M27331 ,TRGC2*07(2X),(cDNA) --- --- --- --- --- --- --- M27332 ,TRGC2*08(2X),(cDNA) --- --- --- --- --- --- ---

TRGC2(2X) designates the polymorphic TRGC2
gene with duplication of exon 2 (EX2T-EX2 or EX2R-EX2) [Buresi, C. et al.,
Immunogenetics, 29, 161-172 (1989)].

TRGC2*01(2X) and TRGC2*02(2X) alleles were previously designated as
gamma2^{b} (D7 gamma2) and gamma2^{a} (D11 gamma2), respectively
[Lefranc, M.-P. et al., Proc. Natl. Acad. Sci. U.S.A., 83, 9596-9600 (1986)].

This alignement has been generated with the IMGT/AlleleAlign tool developed by Mehdi Yousfi (31/07/2001)

Created: 12/01/1998

Last updated: 03/04/2012

Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr

Editors: Manuel Ruiz, Christèle Martinez-Jean, Nathalie Bosc and Joumana Jabado-Michaloud

Software material and data coming from IMGT server may be used for academic research only,
provided that it is referred to IMGT®, and cited as
"IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org
(founder and director: Marie-Paule Lefranc, Montpellier, France)."
References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209
Full text
Cover;
Ruiz, M. et al.,
Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219
Full text;
Lefranc, M.-P.,
Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207
Full text;
Lefranc, M.-P.,
Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085
Full text;
Lefranc, M.-P. et al.,
*In Silico* Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056
Full text.

For any other use please contact Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr.

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