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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

                                                                                                                          
                                  
                                  1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                   X   S   I   Q   A   P   S   I   Y   P   L   R   L   C   C   T 
  U63640   IGHE*01 F CH1 gDNA                     ncc tcc atc cag gct cca tcc atc tac ccc ttg agg ctc tgt tgc aca
                             
                                                                                                                 
  KT723008 IGHE*02 F CH1 gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                             


                                              _____AB_____                                            ____________
                                              15.1    15.3                                                        
                                   13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                   E                       E   A   R   V   R   L   G   C   L   V   K   D   Y   L 
  U63640   IGHE*01 F CH1 gDNA     gaa ... ... ... ... ... gaa gcc cgt gta agg ctg ggc tgc ctg gtc aag gac tac ttg
                             
                                                                                                                 
  KT723008 IGHE*02 F CH1 gDNA     --- ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                             


                                  _______BC___________________                            _____________CD_________
                                                                                          45.1    45.3    45.5    
                                   30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                   P           G   S   V   T   V   T   W   D   T   V   P   L   D   G             
  U63640   IGHE*01 F CH1 gDNA     cca ... ... ggg tca gtg act gtg acc tgg gac aca gtg ccc ctg gat gga ... ... ...
                             
                                                                                                                 
  KT723008 IGHE*02 F CH1 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                             


                                  ____                                ___________________________DE_______________
                                  45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                       77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                       S   T   L   T   F   P   S   I   Q   M   A   S   S                       S 
  U63640   IGHE*01 F CH1 gDNA     ... agc acc ttg acc ttc cct agc atc caa atg gcg agc tcc ... ... ... ... ... agt
                             
                                                                                                                 
  KT723008 IGHE*02 F CH1 gDNA     ... --- --- c-- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
                             


                                  ____________                                                ___EF___            
                                      85.2                                                    96.1                
                                  85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                   L   Y   I   T   T   S   Q   L   T   I   S   G   E                       Q   S 
  U63640   IGHE*01 F CH1 gDNA     ctc tac att acc acc agc cag ctg acc atc tcg ggc gag ... ... ... ... ... cag tcc
                             
                                                                                                               P 
  KT723008 IGHE*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... --- c--
                             


                                                      _________________________FG_________________________        
                                  
                                  100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                   K   E   F   T   C   R   V   L   H   P   E           T   I   Q   L   N   K   T 
  U63640   IGHE*01 F CH1 gDNA     aag gag ttc acc tgc aga gtt tta cac cct gag ... ... aca atc caa ttg aat aag aca
                             
                                                                       A                   N   S   N   L   N   K 
  KT723008 IGHE*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- g-- --- ... ... --c -a- tcc aac ttg --t -ag
                             


                                          
                                  
                                  120 121 
                                   S   T  
  U63640   IGHE*01 F CH1 gDNA     tca act 
                             
                                   T   I   S   T  
  KT723008 IGHE*02 F CH1 gDNA     a-c -tc agc act 
                             










                                                                                                                  
                                  
                                  1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                       E   C   V   K   N   F   S   D   P   S   V   K   L   F   F   S   S   C   N 
  U63640   IGHE*01 F CH2 gDNA         gag tgt gtc aag aac ttc agc gac ccc tca gtg aag ctc ttc ttc tcc tca tgc aac
                             
                                               A                                               Y                 
  KT723008 IGHE*02 F CH2 gDNA         --- --c -c- --- --- --- --- --- --- --- --- --- --- --- -a- --- --c --- ---
                             


                                              _____AB_____                                            ____________
                                              15.1    15.3                                                        
                                   13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                   P   N   G   D   T       Q   T   T   I   H   L   L   C   R   I   S   A   Y   T 
  U63640   IGHE*01 F CH2 gDNA     ccc aat ggc gac acc ... cag acc acc atc cac ctc ctg tgc cgg atc tcc gca tac acc
                             
                                                                                                       G         
  KT723008 IGHE*02 F CH2 gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- -gc --- ---
                             


                                  _______BC___________________                            _____________CD_________
                                                                                          45.1    45.3    45.5    
                                   30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                   P           G   K   I   K   V   T   W   L   V   D   G   L   Q   S   E   E     
  U63640   IGHE*01 F CH2 gDNA     ccg ... ... gga aaa atc aag gtc acc tgg ctg gtg gat ggg ctc cag tcc gaa gag ...
                             
                                                                                               K                 
  KT723008 IGHE*02 F CH2 gDNA     --- ... ... --c --- --- --- --- --- --- --- --- --- --- --- a-- --- --- --- ...
                             


                                  ____                                ___________________________DE_______________
                                  45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                       77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                       L   Y   A   R   S   G   P   E   I   Q   E   G                           N 
  U63640   IGHE*01 F CH2 gDNA     ... ctg tat gca cga tcc ggc cct gag ata cag gag ggc ... ... ... ... ... ... aat
                             
                                                                                                                 
  KT723008 IGHE*02 F CH2 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                             


                                  ____________                                                ___EF___            
                                      85.2                                                    96.1                
                                  85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                   L   T   S   T   Y   S   E   V   N   I   T   Q   G   Q   W           V   S   E 
  U63640   IGHE*01 F CH2 gDNA     ctg acc tcc acc tac agt gaa gtc aac atc aca cag ggc cag tgg ... ... gtg tcc gag
                             
                                                                                                                 
  KT723008 IGHE*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                             


                                                      _________________________FG_________________________        
                                  
                                  100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                   K   T   Y   T   C   R   V   N   Y   Y                   G   Y   N   F   E   S 
  U63640   IGHE*01 F CH2 gDNA     aaa acc tac acc tgc cgg gtc aac tat tac ... ... ... ... ggc tac aac ttc gaa agc
                             
                                                                                                                 
  KT723008 IGHE*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
                             


                                                          
                                  
                                  120 121 122 123 124 125 
                                   H   A   H   R   C   T  
  U63640   IGHE*01 F CH2 gDNA     cac gcc cac agg tgc aca 
                             
                                                          
  KT723008 IGHE*02 F CH2 gDNA     --- --- --- --- --- --- 
                             










                                                                                                                  
                                  
                                  1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                           A   E   S   E   P   R       V   S   A   Y   L   S   P   P   T   P   L 
  U63640   IGHE*01 F CH3 gDNA             gcc gag tcc gag ccc cgc ... gtg agc gcc tac ctg agc cca ccc acc ccc ctc
                             
                                                                   G                                             
  KT723008 IGHE*02 F CH3 gDNA             --- --- --- --- --- --- ggc --- --- --- --- --- --- --- --- --- --- ---
                             


                                              _____AB_____                                            ____________
                                              15.1    15.3                                                        
                                   13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                   E   L   Y   V           N   K   S   P   K   I   T   C   L   V   V   D   L   A 
  U63640   IGHE*01 F CH3 gDNA     gag ctg tac gtc ... ... aac aag tca ccc aag atc acc tgc ctg gtt gtg gac ctg gcc
                             
                                                                                                                 
  KT723008 IGHE*02 F CH3 gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                             


                                  _______BC___________________                            _____________CD_________
                                                                                          45.1    45.3    45.5    
                                   30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                   N   E       K   N   L   S   L   T   W   S   R   A   N   G   K   P   V         
  U63640   IGHE*01 F CH3 gDNA     aac gag ... aag aat ttg agc ctg acc tgg tcg agg gca aac ggg aag cct gtg ... ...
                             
                                                                                                                 
  KT723008 IGHE*02 F CH3 gDNA     --- --- ... --- --c --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                             


                                  ____                                ___________________________DE_______________
                                  45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                       77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                       H   A   G   P   P   E   I   K   R   Q   F   N                           G 
  U63640   IGHE*01 F CH3 gDNA     ... cac gca ggc ccc cct gag atc aag cgt cag ttc aac ... ... ... ... ... ... ggg
                             
                                                                                                                 
  KT723008 IGHE*02 F CH3 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                             


                                  ____________                                                ___EF___            
                                      85.2                                                    96.1                
                                  85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                   T   V   T   V   T   S   T   L   P   V   D   V   T   D   W           V   E   G 
  U63640   IGHE*01 F CH3 gDNA     acg gtc acc gtc acg tcc acc ctg ccg gtg gac gtc act gac tgg ... ... gta gaa ggc
                             
                                                                                                                 
  KT723008 IGHE*02 F CH3 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                             


                                                      _________________________FG_________________________        
                                  
                                  100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                   E   T   Y   Y   C   K   V   S   H   R   D           L   P   T   D   I   Q   R 
  U63640   IGHE*01 F CH3 gDNA     gag acc tac tac tgc aaa gtg agc cac agg gac ... ... ctg ccc aca gac atc cag cga
                             
                                                                       S                                         
  KT723008 IGHE*02 F CH3 gDNA     --- --- --- --- --- --- --- --- --- --c --- ... ... --- --- --g --- --- --- ---
                             


                                                          
                                  
                                  120 121 122 123 124 125 
                                   S   I   S   K   D   V  
  U63640   IGHE*01 F CH3 gDNA     tcc atc tcc aag gat gtt 
                             
                                                          
  KT723008 IGHE*02 F CH3 gDNA     --- --- --- --- --- --- 
                             










                                                                                                                      
                                      
                                      1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                       G   K   R   L   A   P   K   D   Y   V   F   L   A   D   G   K 
  U63640   IGHE*01 F CH4-CHS gDNA                     ggc aag cgt ctg gcc ccc aag gac tac gtg ttc ttg gca gac gga aag
                                 
                                                                                   A                   P             
  KT723008 IGHE*02 F CH4-CHS gDNA                     --- --- --- --- --- --- --- -c- --- --- --- --- c-- --- --- ---
                                 


                                                  _____AB_____                                            ____________
                                                  15.1    15.3                                                        
                                       13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                       E   L   E   N           E   E   E   L   T   L   T   C   M   I   Q   N   F   F 
  U63640   IGHE*01 F CH4-CHS gDNA     gag ctg gag aac ... ... gag gag gag ctc acc ctc acc tgc atg atc cag aac ttc ttc
                                 
                                                                                                           K         
  KT723008 IGHE*02 F CH4-CHS gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --a --- ---
                                 


                                      _______BC___________________                            _____________CD_________
                                                                                              45.1    45.3    45.5    
                                       30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                       P           R   D   I   F   V   R   W   L   H   N   K   E   L   M   G   A   D 
  U63640   IGHE*01 F CH4-CHS gDNA     ccc ... ... agg gac atc ttt gtg cgg tgg ctg cat aac aag gaa ctg atg ggg gca gac
                                 
                                                                                                           R         
  KT723008 IGHE*02 F CH4-CHS gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- c-- --- ---
                                 


                                      ____                                ___________________________DE_______________
                                      45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                           77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                           Q   H   T   T   T   Q   P   H   R   D   D   N   N                   T   P 
  U63640   IGHE*01 F CH4-CHS gDNA     ... cag cac acc acc aca cag ccc cac agg gac gac aac aac ... ... ... ... acc cca
                                 
                                                                               A                                     
  KT723008 IGHE*02 F CH4-CHS gDNA     ... --- --- --- --- --- --- --- --- --- -c- --- --- --- ... ... ... ... --- ---
                                 


                                      ____________                                                ___EF___            
                                          85.2                                                    96.1                
                                      85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                       A   F   F   A   Y   S   R   L   A   V   P   R   A   N   W           K   R   G 
  U63640   IGHE*01 F CH4-CHS gDNA     gcc ttc ttc gcc tac agc cgc ctg gcg gtc cct agg gcc aac tgg ... ... aag agg ggc
                                 
                                                                                                                     
  KT723008 IGHE*02 F CH4-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                 


                                                          _________________________FG_________________________        
                                      
                                      100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                       D   E   F   T   S   Q   V   I   H   E   A   L   P   R   T   R   T   L   E   K 
  U63640   IGHE*01 F CH4-CHS gDNA     gat gag ttc acc tcc caa gtg atc cac gag gca ctg ccc agg act agg acc ctg gag aaa
                                 
                                                       C                                                             
  KT723008 IGHE*02 F CH4-CHS gDNA     --- --- --- --- -g- --- --- --- --t --- --- --- --- --- --- --- --- --- --- ---
                                 


                                                                          __CHS___
                                      
                                      120 121 122 123 124 125 126 127 128 129 130 
                                       S   V   F   I   N   S               G   K  
  U63640   IGHE*01 F CH4-CHS gDNA     tcg gtg ttc att aac agc ... ... ... ggt aaa 
                                 
                                                                                  
  KT723008 IGHE*02 F CH4-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- 
                                 










                                    
                                    
                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                     E   L   A   L   E   D   L   C   A   E   E   A   E   S   E   E   L   E   E   T 
  KT723008 IGHE*02 F M1+M2 gDNA     gag ctg gcc ctc gag gac ctg tgt gca gag gaa gct gag agc gag gag ctg gag gag acc
                               


                                    
                                    
                                     21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                     W   T   S   L   L   V   F   I   V   L   F   L   L   S   M   S   Y   G   A   A 
  KT723008 IGHE*02 F M1+M2 gDNA     tgg acc agc ctc ctt gtc ttc atc gtg ctc ttc ctg ctc agc atg agc tat ggc gcc gcc
                               


                                    
                                    
                                     41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                     V   S   L   C   K   V   K   W   I   L   A   A   I   L   Q   G   Q   P   Q   G 
  KT723008 IGHE*02 F M1+M2 gDNA     gtc agc ctc tgc aag gtg aag tgg atc ctg gcc gcc atc ctc cag ggg cag ccc cag ggc
                               


                                    
                                    
                                     61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76 
                                     S   Q   D   Y   T   N   V   T   Q   R   P   L   P   A   G   V  
  KT723008 IGHE*02 F M1+M2 gDNA     tcc caa gac tac acc aac gtc aca cag cgc cca ctg cct gct ggt gtc 

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux, Mehdi Yousfi and Perrine Pégorier).

Created:
07/11/2017
Authors:
Perrine Pégorier