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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

                                                                                                                             
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                      X   S   T   T   A   P   K   V   Y   P   L   S   S   C   C   G 
  M36946   IGHG2*01 F   CH1 gDNA                     ncc tcc acc aca gcc ccg aaa gtc tac cct ctg agt tct tgc tgc ggg
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH1 gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                
                                                      A                                           A       S         
  S82407   IGHG2*03 (F) CH1 cDNA                     g-- --- --- --- --- --- --- --- --- --- --- gca --c a-- --- --a
                                
                                                                                                  A       R         
  KT723008 IGHG2*04 F   CH1 gDNA                     --- --- --- --- --- --- --- --- --- --- --- gca --c c-- --- --a
                                


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   K   S               S   S   T   V   T   L   G   C   L   V   S   S   Y   M 
  M36946   IGHG2*01 F   CH1 gDNA     gac aag tcc ... ... ... agc tcc acc gtg acc ctg ggc tgc ctg gtg tcc agc tac atg
                                
                                                                      G                                             
  X16702   IGHG2*02 F   CH1 gDNA     --- --- --- ... ... ... --- --g ggg --- --- --- --- --- --- --c --- --- --- ---
                                
                                          T                                                                         
  S82407   IGHG2*03 (F) CH1 cDNA     --- -ca --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                
                                          T                                                                         
  KT723008 IGHG2*04 F   CH1 gDNA     --- -ca --- ... ... ... --- --- --- --- --- --- --- --- --- --c --- --- --- ---
                                


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      P           E   P   V   T   V   T   W   N   S   G   A   L   K   S             
  M36946   IGHG2*01 F   CH1 gDNA     ccc ... ... gag ccg gtg acc gtg acc tgg aac tcg ggt gcc ctg aag agc ... ... ...
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH1 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                
                                                                                                                    
  S82407   IGHG2*03 (F) CH1 cDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                
                                                                                                                    
  KT723008 IGHG2*04 F   CH1 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          G   V   H   T   F   P   A   V   L   Q   S   S                           G 
  M36946   IGHG2*01 F   CH1 gDNA     ... ggc gtg cac acc ttc ccg gcc gtc ctt cag tcc tcc ... ... ... ... ... ... ggg
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                
                                                                                                                    
  S82407   IGHG2*03 (F) CH1 cDNA     ... --- --- --- --- --- --- --t --- --- --- --- --- ... ... ... ... ... ... ---
                                
                                                                                                                    
  KT723008 IGHG2*04 F   CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      L   Y   S   L   S   S   M   V   T   V   P   G   S   T   S               G     
  M36946   IGHG2*01 F   CH1 gDNA     ctc tac tct ctc agc agc atg gtg acc gtg ccc ggc agc acc tca ... ... ... gga ...
                                
                                                                                  A       S                       T 
  X16702   IGHG2*02 F   CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- -c- --- -g- --- ... ... ... --- acc
                                
                                                                                  A       S                         
  S82407   IGHG2*03 (F) CH1 cDNA     --- --- --- --- --- --- --- --- --- --- --- -c- --- -g- --- ... ... ... --- ...
                                
                                                                                          S                         
  KT723008 IGHG2*04 F   CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- -g- --- ... ... ... --- ...
                                


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      Q   T   F   T   C   N   V   A   H   P   A           S   S   T   K   V   D   K 
  M36946   IGHG2*01 F   CH1 gDNA     cag acc ttc acc tgc aac gta gcc cac ccg gcc ... ... agc agc acc aag gtg gac aag
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                
                                                                                                                    
  S82407   IGHG2*03 (F) CH1 cDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                
                                                                                                                    
  KT723008 IGHG2*04 F   CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                


                                             
                                     
                                     120 121 
                                      A   V  
  M36946   IGHG2*01 F   CH1 gDNA     gct gtt 
                                
                                             
  X16702   IGHG2*02 F   CH1 gDNA     --- --- 
                                
                                             
  S82407   IGHG2*03 (F) CH1 cDNA     --- --- 
                                
                                             
  KT723008 IGHG2*04 F   CH1 gDNA     --- --- 
                                










                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12  13 
                                    G   V   S   S   D   C   S   K   P   N   N   Q   H  
  M36946   IGHG2*01 F   H gDNA     ggg gtc tcc agt gac tgc tcc aag cct aat aac cag cat 
                              
                                                                                       
  X16702   IGHG2*02 F   H gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- 
                              
                                                I                   C   H           P  
  S82407   IGHG2*03 (F) H cDNA     --- --- --- -t- --- --- --- --- tg- c-- --- --- -c- 
                              
                                                I                   C   H           P  
  KT723008 IGHG2*04 F   H gDNA     --- --- --- -t- --- --- --- --- tg- c-- --- --- -c- 
                              










                                                                                                                     
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          C       R   E   P   S   V   F   I   F   P   P   K   P   K 
  M36946   IGHG2*01 F   CH2 gDNA (1)                     tgc .tg agg gaa cca tct gtc ttc atc ttc cca ccg aaa ccc aaa
                                
                                                              V                                                     
  X16702   IGHG2*02 F   CH2 gDNA                         --- g-- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                
                                                              V                                                     
  S82407   IGHG2*03 (F) CH2 cDNA                         --- g-- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                
                                                              V                                                     
  KT723008 IGHG2*04 F   CH2 gDNA                         --- g-- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   T   L   M   I       T   G   T   P   E   V   T   C   V   V   V   N   V   G 
  M36946   IGHG2*01 F   CH2 gDNA (1) gac acc ctg atg atc ... aca gga acg ccc gag gtc acg tgt gtg gtg gtg aac gtg ggc
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH2 gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                
                                                                                                                    
  S82407   IGHG2*03 (F) CH2 cDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                
                                                                                                                    
  KT723008 IGHG2*04 F   CH2 gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      H   D   N   P   E   V   Q   F   S   W   F   V   D   D   V   E   V   H         
  M36946   IGHG2*01 F   CH2 gDNA (1) cac gat aac ccc gag gtg cag ttc tcc tgg ttc gtg gac gac gtg gag gtg cac ... ...
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                
                                                                                                                    
  S82407   IGHG2*03 (F) CH2 cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --t --- --- --- --- --- ... ...
                                
                                                                                                                    
  KT723008 IGHG2*04 F   CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --t --- --- --- --- --- ... ...
                                


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          T   A   R   T   K   P   R   E   E   Q   F   N                           S 
  M36946   IGHG2*01 F   CH2 gDNA (1) ... acg gcc agg acg aag ccg aga gag gag cag ttc aac ... ... ... ... ... ... agc
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH2 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                
                                                      S                                                             
  S82407   IGHG2*03 (F) CH2 cDNA     ... --- --- --- t-- --- --a --- --- --- --- --- --- ... ... ... ... ... ... ---
                                
                                                      S                                                             
  KT723008 IGHG2*04 F   CH2 gDNA     ... --- --- --- t-- --- --a --- --- --- --- --- --- ... ... ... ... ... ... ---
                                


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      T   Y   R   V   V   S   A   L   P   I   Q   H   Q   D   W           T   G   G 
  M36946   IGHG2*01 F   CH2 gDNA (1) acg tac cgc gtg gtc agc gcc ctg ccc atc cag cac cag gac tgg ... ... act gga gga
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                
                                                                                                                    
  S82407   IGHG2*03 (F) CH2 cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                
                                                                                                                    
  KT723008 IGHG2*04 F   CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   E   F   K   C   K   V   N   I   K   G           L   S   A   S   I   V   R 
  M36946   IGHG2*01 F   CH2 gDNA (1) aag gag ttc aag tgc aag gtc aac atc aaa ggc ... ... ctc tcg gcc tcc atc gtg agg
                                
                                                                                                                    
  X16702   IGHG2*02 F   CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                
                                                                      N                               P             
  S82407   IGHG2*03 (F) CH2 cDNA     --- --- --- --- --- --- --- --- -a- --- --- ... ... --- --- --- c-- --- --- ---
                                
                                                                      N                               P             
  KT723008 IGHG2*04 F   CH2 gDNA     --- --- --- --- --- --- --- --- -a- --- --- ... ... --- --- --- c-- --- --- ---
                                


                                                             
                                     
                                     120 121 122 123 124 125 
                                      I   I   S   R   S   K  
  M36946   IGHG2*01 F   CH2 gDNA (1) atc atc tcc agg agc aaa 
                                
                                                             
  X16702   IGHG2*02 F   CH2 gDNA     --- --- --- --- --- --- 
                                
                                                             
  S82407   IGHG2*03 (F) CH2 cDNA     --- --- --- --- --- --- 
                                
                                                             
  KT723008 IGHG2*04 F   CH2 gDNA     --- --- --- --- --- --- 
                                










                                                                                                                         
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          G   P   A   R   E   P   Q   V   Y   V   L   D   P   P   K   E 
  M36946   IGHG2*01 F   CH3-CHS gDNA                     ggg ccg gcc cgg gag ccg cag gtg tat gtc ctg gac cca ccc aag gaa
                                    
                                                                                                                        
  X16702   IGHG2*02 F   CH3-CHS gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                    
                                                                                                                        
  S82407   IGHG2*03 (F) CH3-CHS cDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                    
                                                                                                                        
  KT723008 IGHG2*04 F   CH3-CHS gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                    


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          E   L   S               K   S   T   V   S   V   T   C   M   V   I   G   F   Y 
  M36946   IGHG2*01 F   CH3-CHS gDNA     gag ctc agc ... ... ... aaa agc acg gtc agc gtc acc tgc atg gtc atc ggc ttc tac
                                    
                                                                                      L                                 
  X16702   IGHG2*02 F   CH3-CHS gDNA     --- --- --- ... ... ... --- --- --- --- --- c-- --- --- --- --- --- --- --- ---
                                    
                                                                              L                           T             
  S82407   IGHG2*03 (F) CH3-CHS cDNA     --- --- --- ... ... ... --- --- --- c-- --- --- --- --- --- --- -c- --- --- ---
                                    
                                                                              L                           T             
  KT723008 IGHG2*04 F   CH3-CHS gDNA     --- --- --- ... ... ... --- --- --- c-- --- --- --- --- --- --- -c- --- --- ---
                                    


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           E   D   V   D   V   E   W   Q   R   D   R   Q   T   E   S   E   D 
  M36946   IGHG2*01 F   CH3-CHS gDNA     cca ... ... gaa gat gta gac gtg gag tgg cag aga gac cgg cag act gag tcg gag gac
                                    
                                                                                                                        
  X16702   IGHG2*02 F   CH3-CHS gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                    
                                                                  A                       N                             
  S82407   IGHG2*03 (F) CH3-CHS cDNA     --- ... ... --- --- --- -c- --- --- --- --- --- a-- --- --- --- --- --- --- ---
                                    
                                                                  A                       N                             
  KT723008 IGHG2*04 F   CH3-CHS gDNA     --- ... ... --- --- --- -c- --- --- --- --- --- a-- --- --- --- --- --- --- ---
                                    


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              K   Y   R   T   T   P   P   Q   L   D   A   D                           R 
  M36946   IGHG2*01 F   CH3-CHS gDNA     ... aag tac cgc acg acc ccg ccc cag ctg gac gcc gac ... ... ... ... ... ... cgc
                                    
                                                                                                                        
  X16702   IGHG2*02 F   CH3-CHS gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                    
                                                                                      T                                 
  S82407   IGHG2*03 (F) CH3-CHS cDNA     ... --- --- --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... ---
                                    
                                                                                      T                                 
  KT723008 IGHG2*04 F   CH3-CHS gDNA     ... --- --- --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... ---
                                    


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          S   Y   F   L   Y   S   K   L   R   V   D   R   N   S   W           Q   R   G 
  M36946   IGHG2*01 F   CH3-CHS gDNA     tcc tac ttc ctg tac agc aag ctc agg gtg gac agg aac agc tgg ... ... cag aga gga
                                    
                                                                                                                        
  X16702   IGHG2*02 F   CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                    
                                                                                                                  E     
  S82407   IGHG2*03 (F) CH3-CHS cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ga- ---
                                    
                                                                                                                  E     
  KT723008 IGHG2*04 F   CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ga- ---
                                    


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          D   T   Y   T   C   V   V   M   H   E   A       L   H   N   H   Y   M   Q   K 
  M36946   IGHG2*01 F   CH3-CHS gDNA     gac acc tac acg tgt gtg gtg atg cac gag gcc ... ctg cac aat cac tac atg cag aag
                                    
                                                                                                                        
  X16702   IGHG2*02 F   CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                    
                                              A                                                                         
  S82407   IGHG2*03 (F) CH3-CHS cDNA     --- g-- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                    
                                                                                                                        
  KT723008 IGHG2*04 F   CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                    


                                                                             __CHS___
                                         
                                         120 121 122 123 124 125 126 127 128 129 130 
                                          S   T   S   K   S   A               G   K  
  M36946   IGHG2*01 F   CH3-CHS gDNA     tcc acc tct aag tct gcg ... ... ... ggt aaa 
                                    
                                                                                     
  X16702   IGHG2*02 F   CH3-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- 
                                    
                                                                                     
  S82407   IGHG2*03 (F) CH3-CHS cDNA     --- --- --- --- --- --- ... ... ... --- --- 
                                    
                                                                                     
  KT723008 IGHG2*04 F   CH3-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- 
                                    










                                     
                                     
                                      1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                      D   L   L   L   E   E   E   I   C   A   D   A   Q   D   G   E   L   D   G   L 
  KT723008 IGHG2*04 F M1+M2 gDNA     gac ctg ctg ctg gag gag gag atc tgt gcg gac gcc cag gac ggg gag ctg gac ggg ctc
                                


                                     
                                     
                                      21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                      W   T   T   I   S   I   F   I   T   L   F   L   L   S   V   C   Y   S   A   T 
  KT723008 IGHG2*04 F M1+M2 gDNA     tgg acg act atc tcc atc ttc atc aca ctc ttt ctg ctc agc gtc tgc tac agc gcc acc
                                


                                     
                                     
                                      41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                      V   T   L   F   K   V   K   W   I   L   S   S   V   V   E   L   K   Q   S   I 
  KT723008 IGHG2*04 F M1+M2 gDNA     gtg acc ctc ttc aag gtg aag tgg atc ctc tca tcc gtg gtg gag ctg aag cag tcg atc
                                


                                     
                                     
                                      61  62  63  64  65  66  67  68  69  70  71  72 
                                      T   P   N   Y   R   N   M   I   G   Q   G   A  
  KT723008 IGHG2*04 F M1+M2 gDNA     act ccc aac tac aga aac atg atc gga cag ggc gcc 

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

IMGT notes:
  1. (1) This sequence was incorrectly designated a pseudogene because in their first sequence the nucleotide G at position 907/908 was missing. This sequence has been re-sequenced and the nucleotide has been resolved.
Created:
07/11/2017
Authors:
Perrine Pégorier