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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

                                                                                                                           
                                   
                                   1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                    X   G   E   S   H   P   R   V   F   P   L   V   S   C   V   S 
  AY158087 IGHM2*01 F CH1 gDNA                     naa ggt gaa tca cac ccg aga gtc ttc ccc ctg gtg tcc tgc gtg agc
                              
                                                                                                                  
  AY230207 IGHM2*01 F CH1 gDNA                                           - --- --- --- --- --- --- --- --- --- ---
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH1 gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              


                                               _____AB_____                                            ____________
                                               15.1    15.3                                                        
                                    13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                    S   P   S   D           E   S   T   V   A   L   G   C   L   A   R   D   F   V 
  AY158087 IGHM2*01 F CH1 gDNA     tcg cca tcc gat ... ... gag agc acg gtg gcc ctg ggc tgc ctg gcc cgg gac ttc gtg
                              
                                                                                                                  
  AY230207 IGHM2*01 F CH1 gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH1 gDNA     --c --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              


                                   _______BC___________________                            _____________CD_________
                                                                                           45.1    45.3    45.5    
                                    30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                    P           N   S   V   S   F   S   W   K   F   N   N   S   T   V   S   S   E 
  AY158087 IGHM2*01 F CH1 gDNA     ccc ... ... aat tca gtc agc ttc tcc tgg aag ttc aac aac agc aca gtc agc agc gag
                              
                                                                                                                  
  AY230207 IGHM2*01 F CH1 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH1 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              


                                   ____                                ___________________________DE_______________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                        77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                        R   F   W   T   F   P   E   V   L   R   D   G                             
  AY158087 IGHM2*01 F CH1 gDNA     ... aga ttc tgg acc ttc ccc gaa gtc ctg agg gac ggc ... ... ... ... ... ... ...
                              
                                                                                                                  
  AY230207 IGHM2*01 F CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
                              


                                   ____________                                                ___EF___            
                                       85.2                                                    96.1                
                                   85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                    L   W   S   A   S   S   Q   V   V   L   P   S   S   S   A   F   Q   G   P   D 
  AY158087 IGHM2*01 F CH1 gDNA     ttg tgg tcg gcc tcc tct cag gtg gtc ctg ccc tcc tca agc gcc ttt caa ggg ccg gat
                              
                                                                                                                  
  AY230207 IGHM2*01 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              


                                                       _________________________FG_________________________        
                                   
                                   100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                    D   Y   L   V   C   E   V   Q   H   P   K       G   G   K   T   V   G   T   V 
  AY158087 IGHM2*01 F CH1 gDNA     gac tac ctg gtg tgc gaa gtc cag cac ccc aag ... gga gga aag acc gtc ggc acc gtg
                              
                                                                                                                  
  AY230207 IGHM2*01 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                              


                                                       
                                   
                                   120 121 122 123 124 
                                    R   V   I   A   T  
  AY158087 IGHM2*01 F CH1 gDNA     agg gtg atc gct aca 
                              
                                                       
  AY230207 IGHM2*01 F CH1 gDNA     --- --- --- --- ---
                              
                                            V          
  KT723008 IGHM2*02 F CH1 gDNA     --- --- g-- --- --- 
                              










                                                                                                                   
                                   
                                   1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                K   A   E   V   L   S   P   V   V   S   V   F   V   P   P   R   N 
  AY230207 IGHM2*01 F CH2 gDNA                 aag gcg gaa gtg ctg tcc cca gtc gtg agt gtc ttt gtc ccg cct cgc aac
                              
                                                                                                       
  AY158087 IGHM2*01 F CH2 gDNA                  -- --- --- --- --- --- --- --- --- --- --- --- --- --- -
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH2 gDNA                 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              


                                               _____AB_____                                            ____________
                                               15.1    15.3                                                        
                                    13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                    S   L   S   G   D   G   N   S   K   S   S   L   I   C   Q   A   T   D   F   S 
  AY230207 IGHM2*01 F CH2 gDNA     agc ctc tct ggt gac ggc aat agc aag tcc agc ctc atc tgc cag gcc acg gac ttc agc
                              

  AY158087 IGHM2*01 F CH2 gDNA     
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              


                                   _______BC___________________                            _____________CD_________
                                                                                           45.1    45.3    45.5    
                                    30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                    P           K   Q   I   S   L   S   W   F   R   D   G   K   R   I   V   S     
  AY230207 IGHM2*01 F CH2 gDNA     ccc ... ... aaa cag atc tcc ttg tcc tgg ttt cgt gat gga aag cgg ata gtg tct ...
                              

  AY158087 IGHM2*01 F CH2 gDNA     
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH2 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
                              


                                   ____                                ___________________________DE_______________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                        77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                        G   I   S   E   G   Q   V   E   T   V   Q   S   S                   P   I 
  AY230207 IGHM2*01 F CH2 gDNA     ... gga att tct gaa ggc cag gtg gag act gtg cag tcc tca ... ... ... ... ccc ata
                              

  AY158087 IGHM2*01 F CH2 gDNA     
                              
                                                                                                                V 
  KT723008 IGHM2*02 F CH2 gDNA     ... --c --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- g--
                              


                                   ____________                                                ___EF___            
                                       85.2                                                    96.1                
                                   85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                    T   F   R   A   Y   S   M   L   T   I   T   E   R   D   W           L   S   Q 
  AY230207 IGHM2*01 F CH2 gDNA     act ttc agg gcc tac agc atg ctg acc atc acg gag aga gac tgg ... ... ctc agc cag
                              

  AY158087 IGHM2*01 F CH2 gDNA     
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                              


                                                       _________________________FG_________________________        
                                   
                                   100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                    N   V   Y   T   C   Q   V   E   H   N                   K   E   T   F   Q   K 
  AY230207 IGHM2*01 F CH2 gDNA     aac gtg tac acc tgc cag gta gaa cac aac ... ... ... ... aag gaa acc ttc cag aag
                              

  AY158087 IGHM2*01 F CH2 gDNA     
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
                              


                                                                   
                                   
                                   120 121 122 123 124 125 126 127 
                                    N   V   S   S   S   C   D   V  
  AY230207 IGHM2*01 F CH2 gDNA     aac gtg tcc tcc tca tgt gat gtt 
                              

  AY158087 IGHM2*01 F CH2 gDNA     
                              
                                                                   
  KT723008 IGHM2*02 F CH2 gDNA     --- --- --- --- --- --- --- --- 
                              










                                                                                                                   
                                   
                                   1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                    A   P   P   S   P   I   G   V   F   T   I   P   P   S   F   A 
  AY230207 IGHM2*01 F CH3 gDNA                     gca cca cca tct ccc atc ggg gtc ttc acc atc ccc cca tcc ttc gcc
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH3 gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              


                                               _____AB_____                                            ____________
                                               15.1    15.3                                                        
                                    13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                    D   I   F   L           T   K   S   A   K   L   S   C   L   V   T   N   L   A 
  AY230207 IGHM2*01 F CH3 gDNA     gac atc ttc ctc ... ... acg aag tca gcc aag ctg tcc tgt ctg gtc aca aac ctg gcc
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH3 gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                              


                                   _______BC___________________                            _____________CD_________
                                                                                           45.1    45.3    45.5    
                                    30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                    S   Y       D   G   L   N   I   S   W   S   R   Q   N   G   K   A   L         
  AY230207 IGHM2*01 F CH3 gDNA     tcc tat ... gat ggc ctg aac atc agc tgg tcc cgt cag aac ggc aag gcc ctg ... ...
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH3 gDNA     --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                              


                                   ____                                ___________________________DE_______________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                        77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                        E   T   H   T   Y   F   E   R   H   L   N   D                             
  AY230207 IGHM2*01 F CH3 gDNA     ... gag acc cac acg tat ttt gag cga cac ctc aac gac ... ... ... ... ... ... ...
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH3 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
                              


                                   ____________                                                ___EF___            
                                       85.2                                                    96.1                
                                   85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                    T   F   S   A   R   G   E   A   S   V   C   S   E   D   W           E   S   G 
  AY230207 IGHM2*01 F CH3 gDNA     acc ttc agc gcc cgg ggt gag gcc tcg gtc tgc tcg gag gac tgg ... ... gag tcc gga
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH3 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                              


                                                       _________________________FG_________________________        
                                   
                                   100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                    E   E   F   T   C   T   V   A   H   S   D           L   P   F   P   E   K   N 
  AY230207 IGHM2*01 F CH3 gDNA     gag gag ttc acg tgc aca gtg gcc cac tcg gac ... ... ctg ccc ttc cca gaa aag aac
                              
                                                                                                                  
  KT723008 IGHM2*02 F CH3 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                              


                                                           
                                   
                                   120 121 122 123 124 125 
                                    A   V   S   K   P   K  
  AY230207 IGHM2*01 F CH3 gDNA     gcc gtc tcc aag ccc aaa 
                              
                                    T                      
  KT723008 IGHM2*02 F CH3 gDNA     a-- --- --- --- --- --- 
                              










                                                                                                                       
                                       
                                       1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                    D   V   A   M   K   P   P   S   V   Y   L   L   P   P   T   R   E 
  AY230207 IGHM2*01 F CH4-CHS gDNA                 gac gtc gcc atg aaa ccg ccg tcc gtg tac ctg ctg cct cca acg cgg gaa
                                  
                                                                                                                      
  KT723008 IGHM2*02 F CH4-CHS gDNA                 --t --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                  


                                                   _____AB_____                                            ____________
                                                   15.1    15.3                                                        
                                        13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                        Q   L   S   L           R   E   S   A   S   V   T   C   L   V   K   G   F   A 
  AY230207 IGHM2*01 F CH4-CHS gDNA     cag ctg agc ctg ... ... cgg gag tcg gcc tcc gtc acc tgc ctg gtg aag ggc ttc gcg
                                  
                                                                                                                      
  KT723008 IGHM2*02 F CH4-CHS gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                  


                                       _______BC___________________                            _____________CD_________
                                                                                               45.1    45.3    45.5    
                                        30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                        P           A   D   V   F   V   Q   W   L   Q   R   G   E   P   V   T   K   S 
  AY230207 IGHM2*01 F CH4-CHS gDNA     ccc ... ... gcg gac gtg ttc gtg cag tgg ctg cag agg ggg gag ccc gtg acc aag agc
                                  
                                                                                                                      
  KT723008 IGHM2*02 F CH4-CHS gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                  


                                       ____                                ___________________________DE_______________
                                       45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                            77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                            K   Y   V   T   S   S   P   A   P   E   P   Q   D                   P   S 
  AY230207 IGHM2*01 F CH4-CHS gDNA     ... aag tac gtg acc agc agc ccg gcg ccc gag ccc cag gac ... ... ... ... ccc agc
                                  
                                                                                                                      
  KT723008 IGHM2*02 F CH4-CHS gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---
                                  


                                       ____________                                                ___EF___            
                                           85.2                                                    96.1                
                                       85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                        V   Y   F   V   H   S   I   L   T   V   A   E   E   D   W           S   K   G 
  AY230207 IGHM2*01 F CH4-CHS gDNA     gtg tac ttt gtg cac agc atc ctg acg gtg gcc gag gag gac tgg ... ... agc aaa ggg
                                  
                                                                                                                      
  KT723008 IGHM2*02 F CH4-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                  


                                                           _________________________FG_________________________        
                                       
                                       100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                        E   T   Y   T   C   V   V   G   H   E   A       L   P   H   M   V   T   E   R 
  AY230207 IGHM2*01 F CH4-CHS gDNA     gag acc tac acc tgc gtc gtg ggc cac gag gcc ... ctg ccc cac atg gtc acc gag cgg
                                  
                                                                                                                      
  KT723008 IGHM2*02 F CH4-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                  


                                                                           ______________________________________CHS___
                                       
                                       120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                        T   V   D   K   S   T               G   K   P   T   L   Y   N   V   S   L   V 
  AY230207 IGHM2*01 F CH4-CHS gDNA     acc gtg gac aag tcc acc ... ... ... ggt aaa ccc acc ctg tac aac gtg tcc ctg gtc
                                  
                                                                                                                      
  KT723008 IGHM2*02 F CH4-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
                                  


                                       ____________________________________
                                       
                                       140 141 142 143 144 145 146 147 148 
                                        L   S   D   T   A   S   T   C   Y  
  AY230207 IGHM2*01 F CH4-CHS gDNA     ctg tct gac aca gcc agc acc tgc tac 
                                  
                                                                           
  KT723008 IGHM2*02 F CH4-CHS gDNA     --- --- --- --- --- --- --- --- --- 
                                  










                                     
                                     
                                      1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                      E   G   E   V   S   A   E   E   E   G   F   E   N   L   N   T   M   A   S   T 
  AY230207 IGHM2*01 F M1    gDNA (1) gag ggg gag gtg agc gct gag gag gaa ggc ttt gag aac ctc aac acc atg gcc tcc acc
                                
                                                                                                                    
  KT723008 IGHM2*02 F M1+M2 gDNA     --- --- --- --- --- --c --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                


                                     
                                     
                                      21  22  23  24  25  26 
                                      F   I   V   L   F   L  
  AY230207 IGHM2*01 F M1    gDNA (1) ttc atc gtg ctc ttc ctc c
                                
                                                              L   S   L   F   Y   S   T   T   V   T   L   F   K   V 
  KT723008 IGHM2*02 F M1+M2 gDNA     --- --- --- --- --- --- -tg agc ctc ttc tac agc acc acg gtc acc ctg ttc aag gtg
                                


                                     
                                     
                                     

  AY230207 IGHM2*01 F M1    gDNA (1) 
                                
                                      K  
  KT723008 IGHM2*02 F M1+M2 gDNA     aag

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux, Mehdi Yousfi and Perrine Pégorier).

IMGT notes:
  1. (1) Partial in 3'
Created:
07/11/2017
Last updated:
07/12/2017
Authors:
Perrine Pégorier