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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.


                                                                                                                      
                                      
                                      1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                       X   S   K   T   S   P   S   V   F   P   L   S   L   C   H   Q 
  IMGT000001   IGHA*01 F CH1 gDNA                     nag tcc aaa acc agc ccc agt gtg ttc ccg ctg agc ctc tgc cac cag

                                                                                                                     
  AAEX03006125 IGHA*01 F CH1 gDNA                      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                     
  L36871       IGHA*02 F CH1 gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                                  _____AB_____                                            ____________
                                                  15.1    15.3                                                        
                                       13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                       E   S                   E   G   Y   V   V   I   G   C   L   V   Q   G   F   F 
  IMGT000001   IGHA*01 F CH1 gDNA     gag tca ... ... ... ... gaa ggg tac gtg gtc atc ggc tgc ctg gtg cag gga ttc ttc

                                                                                                                     
  AAEX03006125 IGHA*01 F CH1 gDNA     --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                     
  L36871       IGHA*02 F CH1 gDNA     --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                      _______BC___________________                            _____________CD_________
                                                                                              45.1    45.3    45.5    
                                       30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                       P   P       E   P   V   N   V   T   W   N   A   G   K   D   S   T             
  IMGT000001   IGHA*01 F CH1 gDNA     cca ccg ... gag cct gtg aac gtg acc tgg aat gcc ggc aag gac agc aca ... ... ...

                                                                                                                     
  AAEX03006125 IGHA*01 F CH1 gDNA     --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...

                                                                                                                     
  L36871       IGHA*02 F CH1 gDNA     --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...



                                      ____                                ___________________________DE_______________
                                      45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                           77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                           S   V   K   N   F   P   P   M   K   A   A   T   G                       S 
  IMGT000001   IGHA*01 F CH1 gDNA     ... tct gtc aag aac ttc ccc ccc atg aag gct gct acc gga ... ... ... ... ... agc

                                                                                                                     
  AAEX03006125 IGHA*01 F CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---

                                                                                                                     
  L36871       IGHA*02 F CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---



                                      ____________                                                ___EF___            
                                          85.2                                                    96.1                
                                      85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                       L   Y   T   M   S   S   Q   L   T   L   P   A   A   Q   C           P   D   D 
  IMGT000001   IGHA*01 F CH1 gDNA     cta tac acc atg agc agc cag ttg acc ctg cca gcc gcc cag tgc ... ... cct gat gac

                                                                                                                     
  AAEX03006125 IGHA*01 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---

                                                                                                                     
  L36871       IGHA*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---



                                                          _________________________FG_________________________        
                                      
                                      100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                       S   S   V   K   C   Q   V   Q   H   A               S   S   P   S   K   A   V 
  IMGT000001   IGHA*01 F CH1 gDNA     tcg tct gtg aaa tgc caa gtg cag cat gct ... ... ... tcc agc ccc agc aag gca gtg

                                                                                                                     
  AAEX03006125 IGHA*01 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- ---

                                                                                                                     
  L36871       IGHA*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- ---



                                                          
                                      
                                      120 121 122 123 124 
                                       S   V   P   C   K  
  IMGT000001   IGHA*01 F CH1 gDNA     tct gtg ccc tgc aaa 

                                                          
  AAEX03006125 IGHA*01 F CH1 gDNA     --- --- --- --- --- g

                                                          
  L36871       IGHA*02 F CH1 gDNA     --- --- --- --- --- 

                                    
                                    
                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18 
                                     D   N   C   H   P   C   P   H   P   S   P   S                          
  IMGT000001   IGHA*01 F H gDNA     gat aac tgt cat ccg tgt cct cat cca agt ccc tcg                         

                                                                                                            
  AAEX03006125 IGHA*01 F H gDNA      -- --- --- --- --- --- --- --- --- --- --- ---                         

                                             S                           C                                  
  L36871       IGHA*02 F H gDNA     --- --- a-- --- --- --- ... --- --- t-- --- ---                         

                                                                                                                      
                                      
                                      1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                       C   N   E   P   R   L   S   L   Q   K   P   A   L   E   D   L   L   L         
  IMGT000001   IGHA*01 F CH2 gDNA     tgc aat gag ccc cgc ctg tca cta cag aag cca gcc ctc gag gat ctg ctt tta ... ...

                                                                                                                     
  AAEX03006125 IGHA*01 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...

                                                                                                                     
  L36871       IGHA*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...



                                                  _____AB_____                                            ____________
                                                  15.1    15.3                                                        
                                       13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                       G   S   N   A   S   L   T   C   T   L   S   G   L   K   D   P       K   G   A 
  IMGT000001   IGHA*01 F CH2 gDNA     ggc tcc aat gcc agc ctc aca tgc aca ctg agt ggc ctg aaa gac ccc ... aag ggt gcc

                                                                                                                     
  AAEX03006125 IGHA*01 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... --- --- ---

                                                                                                                     
  L36871       IGHA*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... --- --- ---



                                      _______BC___________________                            _____________CD_________
                                                                                              45.1    45.3    45.5    
                                       30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                       T   F   T   W   N   P   S   K   G   K   E                   P   I   Q   K   N 
  IMGT000001   IGHA*01 F CH2 gDNA     acc ttc acc tgg aac ccc tcc aaa ggg aag gaa ... ... ... ... ccc atc cag aag aat

                                                                                                                     
  AAEX03006125 IGHA*01 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- ---

                                                                                                                     
  L36871       IGHA*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- ---



                                      ____                                ___________________________DE_______________
                                      45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                           77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                       P   E   R   D   S   C   G                               C   Y   S   V   S   S 
  IMGT000001   IGHA*01 F CH2 gDNA     cct gag cgt gac tcc tgt ggc ... ... ... ... ... ... ... tgc tac agt gtg tcc agt

                                                                                                                     
  AAEX03006125 IGHA*01 F CH2 gDNA     --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- --- --- --- --- ---

                                                                                                                     
  L36871       IGHA*02 F CH2 gDNA     --- --- --- --- --- --- --- ... ... ... ... ... ... ... --- --- --- --- --- ---



                                      ____________                                                ___EF___            
                                          85.2                                                    96.1                
                                      85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                       V   L   P   G   C   A   D   P   W           N   H   G   D   T   F   S   C   T 
  IMGT000001   IGHA*01 F CH2 gDNA     gtc cta cca ggc tgt gct gat cca tgg ... ... aac cat ggg gac acc ttc tcc tgc aca

                                                                                                                     
  AAEX03006125 IGHA*01 F CH2 gDNA     --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- ---

                                                                                                                     
  L36871       IGHA*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- ---



                                                          _________________________FG_________________________        
                                      
                                      100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                       A   T   H   P   E           S   K   S   P   I   T   V   S   I   T   K   T   T  
  IMGT000001   IGHA*01 F CH2 gDNA     gcc acc cac cct gaa ... ... tcc aag agc ccg atc act gtc agc atc acc aaa acc aca 

                                                                                                                      
  AAEX03006125 IGHA*01 F CH2 gDNA     --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                      
  L36871       IGHA*02 F CH2 gDNA     --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- 



                                      
                                      
                                      

  IMGT000001   IGHA*01 F CH2 gDNA     


  AAEX03006125 IGHA*01 F CH2 gDNA     g


  L36871       IGHA*02 F CH2 gDNA     

                                                                                                                          
                                          
                                          1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                               E   H   I   P   P   Q   V   H   L   L   P   P   P   S   E 
  IMGT000001   IGHA*01 F CH3-CHS gDNA                         gag cac atc ccg ccc cag gtc cac ctg ctg ccg ccg ccg tcg gaa

                                                                                                                         
  AAEX03006125 IGHA*01 F CH3-CHS gDNA                          -- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                         
  L36871       IGHA*02 F CH3-CHS gDNA                         --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                                      _____AB_____                                            ____________
                                                      15.1    15.3                                                        
                                           13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                           E   L   A   L           N   E   L   V   T   L   T   C   L   V   R   G   F   K 
  IMGT000001   IGHA*01 F CH3-CHS gDNA     gag ctg gcc ctc ... ... aat gag ctg gtg aca ctg acg tgc ttg gtg agg ggc ttc aaa

                                                                                                                         
  AAEX03006125 IGHA*01 F CH3-CHS gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                         
  L36871       IGHA*02 F CH3-CHS gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                          _______BC___________________                            _____________CD_________
                                                                                                  45.1    45.3    45.5    
                                           30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                           P           K   D   V   L   V   R   W   L   Q   G   T   Q   E   L   P   Q   E 
  IMGT000001   IGHA*01 F CH3-CHS gDNA     cca ... ... aaa gat gtg ctc gta cga tgg ctg caa ggg acc cag gag cta ccc caa gag

                                                                                                                         
  AAEX03006125 IGHA*01 F CH3-CHS gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                         
  L36871       IGHA*02 F CH3-CHS gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                          ____                                ___________________________DE_______________
                                          45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                               77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                               K   Y   L   T   W   E   P   L   K   E   P   D   Q                   T   N 
  IMGT000001   IGHA*01 F CH3-CHS gDNA     ... aag tac ttg acc tgg gag ccc ctg aag gag cct gac cag ... ... ... ... acc aac

                                                                                                                         
  AAEX03006125 IGHA*01 F CH3-CHS gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---

                                                                                                                         
  L36871       IGHA*02 F CH3-CHS gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---



                                          ____________                                                ___EF___            
                                              85.2                                                    96.1                
                                          85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                           M   F   A   V   T   S   M   L   R   V   T   A   E   D   W           K   Q   G 
  IMGT000001   IGHA*01 F CH3-CHS gDNA     atg ttt gcc gtg acc agc atg ctg agg gtg aca gcc gaa gac tgg ... ... aag cag ggg

                                                                                                                         
  AAEX03006125 IGHA*01 F CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---

                                                                                                                         
  L36871       IGHA*02 F CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---



                                                              _________________________FG_________________________        
                                          
                                          100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                           E   K   F   S   C   M   V   G   H   E   A       L   P   M   S   F   T   Q   K 
  IMGT000001   IGHA*01 F CH3-CHS gDNA     gag aag ttc tcc tgc atg gtg ggc cac gag gct ... ctg ccc atg tcc ttc acc cag aag

                                                                                                                         
  AAEX03006125 IGHA*01 F CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---

                                                                                                                         
  L36871       IGHA*02 F CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---



                                                                              ______________________________________CHS___
                                          
                                          120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                           T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  IMGT000001   IGHA*01 F CH3-CHS gDNA     acc atc gac cgc ctg gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc

                                                                                                                         
  AAEX03006125 IGHA*01 F CH3-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                         
  L36871       IGHA*02 F CH3-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---



                                          ____________________________________
                                          
                                          140 141 142 143 144 145 146 147 148 
                                           M   A   E   V   D   G   I   C   Y  
  IMGT000001   IGHA*01 F CH3-CHS gDNA     atg gca gag gtg gac ggc atc tgc tac 

                                                                              
  AAEX03006125 IGHA*01 F CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- 

                                                                              
  L36871       IGHA*02 F CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- 

                                    
                                    
                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                     D   S   Q   C   L   A   G   Y   R   E   P   L   P   W   L   V   L   D   L   S 
  IMGT000001   IGHA*01 F M gDNA     gac tca cag tgt ctt gca ggt tac cgg gag cca ctt ccc tgg ctg gtg ctg gac ctg tcg

                                                                                                                   
  AAEX03006125 IGHA*01 F M gDNA      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                    
                                    
                                     21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                     Q   E   D   L   E   E   D   A   P   G   A   S   L   W   P   T   T   V   T   L 
  IMGT000001   IGHA*01 F M gDNA     cag gag gac ctg gag gag gat gcc cca gga gcc agc ctg tgg ccc act acc gtc acc ctt

                                                                                                                   
  AAEX03006125 IGHA*01 F M gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                    
                                    
                                     41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                     L   T   L   F   L   L   S   L   F   Y   S   T   A   L   T   V   T   S   V   R 
  IMGT000001   IGHA*01 F M gDNA     ctc acc ctc ttc cta ctg agt ctc ttc tac agc aca gca ctg act gtg aca agc gtg cgg

                                                                                                                   
  AAEX03006125 IGHA*01 F M gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                    
                                    
                                     61  62  63  64  65  66  67  68  69  70  71 
                                     G   P   T   D   S   R   E   G   P   Q   Y  
  IMGT000001   IGHA*01 F M gDNA     ggc cca act gac agc aga gag ggc ccc cag tac 

                                                                                
  AAEX03006125 IGHA*01 F M gDNA     --- --- --- --- --- --- --- --- --- --- --- 


This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux, Mehdi Yousfi and Perrine Pégorier).

Created:
05/05/2015
Last updated:
17/05/2018
Authors:
Géraldine Folch and Saida Hadi-Saljoqi