Here you are: IMGT Web resources > IMGT Repertoire > Proteins and alleles

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.


                                                                                                                      
                                      
                                      1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                       X   T   S   Q   D   L   S   V   F   P   L   A   S   C   C   K 
  IMGT000001   IGHE*01 F CH1 gDNA                     ncc acc agc cag gac ctg tct gtg ttc ccc ttg gcc tcc tgc tgt aaa

                                                                                                                     
  AAEX03006125 IGHE*01 F CH1 gDNA                      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH1 gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                                  _____AB_____                                            ____________
                                                  15.1    15.3                                                        
                                       13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                       D   N   I   A           S   T   S   V   T   L   G   C   L   V   T   G   Y   L 
  IMGT000001   IGHE*01 F CH1 gDNA     gac aac atc gcc ... ... agt acc tct gtt aca ctg ggc tgt ctg gtc acc ggc tat ctc

                                                                                                                     
  AAEX03006125 IGHE*01 F CH1 gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH1 gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                      _______BC___________________                            _____________CD_________
                                                                                              45.1    45.3    45.5    
                                       30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                       P           M   S   T   T   V   T   W   D   T   G   S   L   N   K             
  IMGT000001   IGHE*01 F CH1 gDNA     ccc ... ... atg tcg aca act gtg acc tgg gac acg ggg tct cta aat aag ... ... ...

                                                                                                                     
  AAEX03006125 IGHE*01 F CH1 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...

                                                                                                                     
  L36872       IGHE*02 F CH1 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...



                                      ____                                ___________________________DE_______________
                                      45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                           77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                           N   V   T   T   F   P   T   T   F   H   E   T   Y                       G 
  IMGT000001   IGHE*01 F CH1 gDNA     ... aat gtc acg acc ttc ccc acc acc ttc cac gag acc tac ... ... ... ... ... ggc

                                                                                                                     
  AAEX03006125 IGHE*01 F CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---

                                                                                                                     
  L36872       IGHE*02 F CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---



                                      ____________                                                ___EF___            
                                          85.2                                                    96.1                
                                      85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                       L   H   S   I   V   S   Q   V   T   A   S   G   E   W                   A   K 
  IMGT000001   IGHE*01 F CH1 gDNA     ctc cac agc atc gtc agc cag gtg acc gcc tcg ggc gag tgg ... ... ... ... gcc aaa

                                                                                                                     
  AAEX03006125 IGHE*01 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---

                                                                                       K                             
  L36872       IGHE*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- a-- --- ... ... ... ... --- ---



                                                          _________________________FG_________________________        
                                      
                                      100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                       Q   R   F   T   C   S   V   A   H   A               E   S   T   A   I   N   K 
  IMGT000001   IGHE*01 F CH1 gDNA     cag agg ttc acc tgc agc gtg gct cac gct ... ... ... gag tcc acc gcc atc aac aag

                                                                                                                     
  AAEX03006125 IGHE*01 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- ---



                                                  
                                      
                                      120 121 122 
                                       T   F   S  
  IMGT000001   IGHE*01 F CH1 gDNA     acc ttc agt 

                                                  
  AAEX03006125 IGHE*01 F CH1 gDNA     --- --- --- g

                                                  
  L36872       IGHE*02 F CH1 gDNA     --- --- --- 

                                                                                                                      
                                      
                                      1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                           A   C   A   L   N   F   I   P   P   T   V   K   L   F   H   S   S   C   N 
  IMGT000001   IGHE*01 F CH2 gDNA         gca tgt gcc tta aac ttc att ccg cct acc gtg aag ctc ttc cac tcc tcc tgc aac

                                                                                                                     
  AAEX03006125 IGHE*01 F CH2 gDNA          -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH2 gDNA         --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                                  _____AB_____                                            ____________
                                                  15.1    15.3                                                        
                                       13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                       P   V   G   D   T       H   T   T   I   Q   L   L   C   L   I   S   G   Y   V 
  IMGT000001   IGHE*01 F CH2 gDNA     ccc gtc ggt gat acc ... cac acc acc atc cag ctc ctg tgc ctc atc tct ggc tac gtc

                                                                                                                     
  AAEX03006125 IGHE*01 F CH2 gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH2 gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                      _______BC___________________                            _____________CD_________
                                                                                              45.1    45.3    45.5    
                                       30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                       P           G   D   M   E   V   I   W   L   V   D   G   Q   K   A   T   N     
  IMGT000001   IGHE*01 F CH2 gDNA     cca ... ... ggt gac atg gag gtc atc tgg ctg gtg gat ggg caa aag gct aca aac ...

                                                                                                                     
  AAEX03006125 IGHE*01 F CH2 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...

                                                                                                                     
  L36872       IGHE*02 F CH2 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...



                                      ____                                ___________________________DE_______________
                                      45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                           77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                           I   F   P   Y   T   A   P   G   T   K   E   G                           N 
  IMGT000001   IGHE*01 F CH2 gDNA     ... ata ttc cca tac act gca ccc ggc aca aag gag ggc ... ... ... ... ... ... aac

                                                                                                                     
  AAEX03006125 IGHE*01 F CH2 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---

                                                                                                                     
  L36872       IGHE*02 F CH2 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---



                                      ____________                                                ___EF___            
                                          85.2                                                    96.1                
                                      85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                       V   T   S   T   H   S   E   L   N   I   T   Q   G   E   W           V   S   Q 
  IMGT000001   IGHE*01 F CH2 gDNA     gtg acc tct acc cac agc gag ctc aac atc acc cag ggc gag tgg ... ... gta tcc caa

                                                                                                                     
  AAEX03006125 IGHE*01 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---



                                                          _________________________FG_________________________        
                                      
                                      100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                       K   T   Y   T   C   Q   V   T   Y   Q                   G   F   T   F   K   D 
  IMGT000001   IGHE*01 F CH2 gDNA     aaa acc tac acc tgc cag gtc acc tat caa ... ... ... ... ggc ttt acc ttt aaa gat

                                                                                                                     
  AAEX03006125 IGHE*01 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---



                                                              
                                      
                                      120 121 122 123 124 125 
                                       E   A   R   K   C   S  
  IMGT000001   IGHE*01 F CH2 gDNA     gag gct cgc aag tgc tca 

                                                              
  AAEX03006125 IGHE*01 F CH2 gDNA     --- --- --- --- --- --- g

                                                              
  L36872       IGHE*02 F CH2 gDNA     --- --- --- --- --- --- 

                                                                                                                      
                                      
                                      1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                   E   S   D   P   R   G   V   S   S   Y   L   S   P   P   S   P   L 
  IMGT000001   IGHE*01 F CH3 gDNA                 gag tcc gac ccc cga ggc gtg agc agc tac ctg agc cca ccc agc ccc ctt

                                                                                                                     
  AAEX03006125 IGHE*01 F CH3 gDNA                  -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                               T                                     
  L36872       IGHE*02 F CH3 gDNA                 --- --- --- --- --- --- --- -cg --- --- --- --- --- --- --- --- ---



                                                  _____AB_____                                            ____________
                                                  15.1    15.3                                                        
                                       13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                       D   L   Y   V           H   K   A   P   K   I   T   C   L   V   V   D   L   A 
  IMGT000001   IGHE*01 F CH3 gDNA     gac ctg tat gtc ... ... cac aag gcg ccc aag atc acc tgc ctg gta gtg gac ctg gcc

                                                                                                                     
  AAEX03006125 IGHE*01 F CH3 gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH3 gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                      _______BC___________________                            _____________CD_________
                                                                                              45.1    45.3    45.5    
                                       30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                       T   M       E   G   M   N   L   T   W   Y   R   E   S   K   E   P   V         
  IMGT000001   IGHE*01 F CH3 gDNA     acc atg ... gaa ggc atg aac ctg acc tgg tac cgg gag agc aaa gaa ccc gtg ... ...

                                                                                                                     
  AAEX03006125 IGHE*01 F CH3 gDNA     --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...

                                                                                                                     
  L36872       IGHE*02 F CH3 gDNA     --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...



                                      ____                                ___________________________DE_______________
                                      45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                           77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                           N   P   G   P   L   N   K   K   D   H   F   N                           G 
  IMGT000001   IGHE*01 F CH3 gDNA     ... aac ccg ggc cct ttg aac aag aag gat cac ttc aat ... ... ... ... ... ... ggg

                                                                                                                     
  AAEX03006125 IGHE*01 F CH3 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---

                                                                                                                     
  L36872       IGHE*02 F CH3 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---



                                      ____________                                                ___EF___            
                                          85.2                                                    96.1                
                                      85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                       T   I   T   V   T   S   T   L   P   V   N   T   N   D   W           I   E   G 
  IMGT000001   IGHE*01 F CH3 gDNA     acg atc aca gtc acg tct acc ctg cca gtg aac acc aat gac tgg ... ... atc gag ggc

                                                                                                                     
  AAEX03006125 IGHE*01 F CH3 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH3 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---



                                                          _________________________FG_________________________        
                                      
                                      100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                       E   T   Y   Y   C   R   V   T   H   P   H           L   P   K   D   I   V   R 
  IMGT000001   IGHE*01 F CH3 gDNA     gag acc tac tat tgc agg gtg acc cac ccg cac ... ... ctg ccc aag gac atc gtg cgc

                                                                                                                     
  AAEX03006125 IGHE*01 F CH3 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---

                                                                                                                     
  L36872       IGHE*02 F CH3 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---



                                                              
                                      
                                      120 121 122 123 124 125 
                                       S   I   A   K   A   P  
  IMGT000001   IGHE*01 F CH3 gDNA     tcc att gcc aag gcc cct 

                                                              
  AAEX03006125 IGHE*01 F CH3 gDNA     --- --- --- --- --- --- g

                                                              
  L36872       IGHE*02 F CH3 gDNA     --- --- --- --- --- --- 

                                                                                                                          
                                          
                                          1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                           G   K   R   A   P   P   D   V   Y   L   F   L   P   P   E   E 
  IMGT000001   IGHE*01 F CH4-CHS gDNA                     ggc aag cgt gcc ccc ccg gat gtg tac ttg ttc ctg cca ccg gag gag

                                                                                                                         
  AAEX03006125 IGHE*01 F CH4-CHS gDNA                      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                         
  L36872       IGHE*02 F CH4-CHS gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                                      _____AB_____                                            ____________
                                                      15.1    15.3                                                        
                                           13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                           E   Q   G   T           K   D   R   V   T   L   T   C   L   I   Q   N   F   F 
  IMGT000001   IGHE*01 F CH4-CHS gDNA     gag cag ggg acc ... ... aag gac aga gtc acc ctc acg tgc ctg atc cag aac ttc ttc

                                                                                                                         
  AAEX03006125 IGHE*01 F CH4-CHS gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                         
  L36872       IGHE*02 F CH4-CHS gDNA     --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                          _______BC___________________                            _____________CD_________
                                                                                                  45.1    45.3    45.5    
                                           30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                           P           A   D   I   S   V   Q   W   L   R   N   D   S   P   I   Q   T   D 
  IMGT000001   IGHE*01 F CH4-CHS gDNA     ccc ... ... gcg gac att tca gtg caa tgg ctg cga aac gac agc ccc atc cag aca gac

                                                                                                                         
  AAEX03006125 IGHE*01 F CH4-CHS gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                         
  L36872       IGHE*02 F CH4-CHS gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                          ____                                ___________________________DE_______________
                                          45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                               77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                               Q   Y   T   T   T   G   P   H   K   V   S   G   S                   R   P 
  IMGT000001   IGHE*01 F CH4-CHS gDNA     ... cag tac acc acc acg ggg ccc cac aag gtc tcg ggc tcc ... ... ... ... agg cct

                                                                                                                         
  AAEX03006125 IGHE*01 F CH4-CHS gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---

                                                                                                                         
  L36872       IGHE*02 F CH4-CHS gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---



                                          ____________                                                ___EF___            
                                              85.2                                                    96.1                
                                          85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                           A   F   F   I   F   S   R   L   E   V   S   R   V   D   W           E   Q   K 
  IMGT000001   IGHE*01 F CH4-CHS gDNA     gcc ttc ttc atc ttc agc cgc ctg gag gtt agc cgg gtg gac tgg ... ... gag cag aaa

                                                                                                                         
  AAEX03006125 IGHE*01 F CH4-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---

                                                                                                                         
  L36872       IGHE*02 F CH4-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---



                                                              _________________________FG_________________________        
                                          
                                          100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                           N   K   F   T   C   Q   V   V   H   E   A   L   S   G   S   R   I   L   Q   K 
  IMGT000001   IGHE*01 F CH4-CHS gDNA     aac aaa ttc acc tgc caa gtg gtg cat gag gcg ctg tcc ggc tct agg atc ctc cag aaa

                                                                                                                         
  AAEX03006125 IGHE*01 F CH4-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                         
  L36872       IGHE*02 F CH4-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                                                              __CHS___
                                          
                                          120 121 122 123 124 125 126 127 128 129 130 
                                           W   V   S   K   T   P               G   K  
  IMGT000001   IGHE*01 F CH4-CHS gDNA     tgg gtg tcc aaa acc ccc ... ... ... ggt aaa 

                                                                                      
  AAEX03006125 IGHE*01 F CH4-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- 

                                                                                      
  L36872       IGHE*02 F CH4-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- 

                                        
                                        
                                         1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                         E   L   Q   E   L   C   A   D   A   T   E   S   E   E   L   D   E   L   W   A 
  IMGT000001   IGHE*01 F M1+M2 gDNA     gag ctc cag gag ctg tgc gcg gat gcc act gag agt gag gag ctg gac gag ctg tgg gcc

                                                                                                                       
  AAEX03006125 IGHE*01 F M1+M2 gDNA      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                        
                                        
                                         21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                         S   L   L   I   F   I   T   L   F   L   L   S   V   S   Y   G   A   T   S   T 
  IMGT000001   IGHE*01 F M1+M2 gDNA     agc ctg ctc atc ttc atc acc ctc ttc ctg ctc agc gtg agc tac ggc gcc acc agc acc

                                                                                                                       
  AAEX03006125 IGHE*01 F M1+M2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                        
                                        
                                         41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                         L   F   K   V   K   W   V   L   A   T   V   L   Q   E   K   P   Q   A   A   Q 
  IMGT000001   IGHE*01 F M1+M2 gDNA     ctc ttc aag gtg aag tgg gta ctc gcc acc gtc ctg cag gag aag cca cag gcc gcc caa

                                                                                                                       
  AAEX03006125 IGHE*01 F M1+M2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                        
                                        
                                         61  62  63  64  65  66  67  68  69  70 
                                         D   Y   A   N   I   V   R   P   A   Q  
  IMGT000001   IGHE*01 F M1+M2 gDNA     gac tac gcc aac atc gtg cgg ccg gca cag 

                                                                                
  AAEX03006125 IGHE*01 F M1+M2 gDNA     --- --- --- --- --- --- --- --- --- --- 


This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux, Mehdi Yousfi and Perrine Pégorier).

Created:
05/05/2015
Last updated:
17/05/2018
Authors:
Géraldine Folch and Saida Hadi-Saljoqi