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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.


                                                                                                                         
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          X   S   T   T   A   P   S   V   F   P   L   A   P   S   C   G 
  IMGT000001   IGHG2*01 F   CH1 gDNA                     ncc tcc acc acg gcc ccc tcg gtt ttc cca ctg gcc ccc agc tgc ggg

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH1 gDNA                      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                          A                                                             
  AF354265     IGHG2*02 (F) CH1 cDNA                     g-- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          S   T   S               G   S   T   V   A   L   A   C   L   V   S   G   Y   F 
  IMGT000001   IGHG2*01 F   CH1 gDNA     tcc act tcc ... ... ... ggc tcc acg gtg gcc ctg gcc tgc ctg gtg tca ggc tac ttc

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH1 gDNA     --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH1 cDNA     --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           E   P   V   T   V   S   W   N   S   G   S   L   T   S             
  IMGT000001   IGHG2*01 F   CH1 gDNA     ccc ... ... gag cct gta act gtg tcc tgg aat tcc ggc tcc ttg acc agc ... ... ...

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH1 gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...

                                                                                                                        
  AF354265     IGHG2*02 (F) CH1 cDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...



                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              G   V   H   T   F   P   S   V   L   Q   S   S                           G 
  IMGT000001   IGHG2*01 F   CH1 gDNA     ... ggt gtg cac acc ttc ccg tcc gtc ctg cag tcc tca ... ... ... ... ... ... ggg

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH1 cDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---



                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          L   Y   S   L   S   S   M   V   T   V   P   S   S   R   W               P   S 
  IMGT000001   IGHG2*01 F   CH1 gDNA     ctc tac tcc ctc agc agc atg gtg aca gtg ccc tcc agc agg tgg ... ... ... ccc agc

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH1 cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---



                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          E   T   F   T   C   N   V   A   H   P   A           S   K   T   K   V   D   K 
  IMGT000001   IGHG2*01 F   CH1 gDNA     gag acc ttc acc tgc aac gtg gcc cac ccg gcc ... ... agc aaa act aaa gta gac aag

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH1 cDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---



                                             
                                         
                                         120 
                                          P  
  IMGT000001   IGHG2*01 F   CH1 gDNA     cca 

                                             
  AAEX03006126 IGHG2*01 F   CH1 gDNA     --- g

                                             
  AF354265     IGHG2*02 (F) CH1 cDNA     --- 

                                       
                                       
                                        1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19 
                                        V   P   K   R   E   N   G   R   V   P   R   P   P   D   C   P   K   C   P  
  IMGT000001   IGHG2*01 F   H gDNA     gtg ccc aaa aga gaa aat gga aga gtt cct cgc cca cct gat tgt ccc aaa tgc cca 

                                                                                                                   
  AAEX03006126 IGHG2*01 F   H gDNA      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- g

                                                                                                                   
  AF354265     IGHG2*02 (F) H cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                         
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                  A   P   E   M   L   G   G   P   S   V   F   I   F   P   P   K   P   K 
  IMGT000001   IGHG2*01 F   CH2 gDNA             gcc cct gaa atg ctg gga ggg cct tcg gtc ttc atc ttt ccc ccg aaa ccc aag

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH2 gDNA              -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH2 cDNA             --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          D   T   L   L   I       A   R   T   P   E   V   T   C   V   V   V   D   L   D 
  IMGT000001   IGHG2*01 F   CH2 gDNA     gac acc ctc ttg att ... gcc cga aca cct gag gtc aca tgt gtg gtg gtg gat ctg gac

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH2 gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH2 cDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P   E   D   P   E   V   Q   I   S   W   F   V   D   G   K   Q   M   Q         
  IMGT000001   IGHG2*01 F   CH2 gDNA     cca gaa gac cct gag gtg cag atc agc tgg ttc gtg gac ggt aag cag atg caa ... ...

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...

                                                                                                                        
  AF354265     IGHG2*02 (F) CH2 cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...



                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              T   A   K   T   Q   P   R   E   E   Q   F   N                           G 
  IMGT000001   IGHG2*01 F   CH2 gDNA     ... aca gcc aag act cag cct cgt gag gag cag ttc aat ... ... ... ... ... ... ggc

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH2 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH2 cDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---



                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          T   Y   R   V   V   S   V   L   P   I   G   H   Q   D   W           L   K   G 
  IMGT000001   IGHG2*01 F   CH2 gDNA     acc tac cgt gtg gtc agt gtc ctc ccc att ggg cac cag gac tgg ... ... ctc aag ggg

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH2 cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---



                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          K   Q   F   T   C   K   V   N   N   K   A           L   P   S   P   I   E   R 
  IMGT000001   IGHG2*01 F   CH2 gDNA     aag cag ttc acg tgc aaa gtc aac aac aaa gcc ... ... ctc cca tcc ccg atc gag agg

                                                                                                                        
  AAEX03006126 IGHG2*01 F   CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---

                                                                                                                        
  AF354265     IGHG2*02 (F) CH2 cDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---



                                                                 
                                         
                                         120 121 122 123 124 125 
                                          T   I   S   K   A   R  
  IMGT000001   IGHG2*01 F   CH2 gDNA     acc atc tcc aag gcc aga 

                                                                 
  AAEX03006126 IGHG2*01 F   CH2 gDNA     --- --- --- --- --- --- g

                                                                 
  AF354265     IGHG2*02 (F) CH2 cDNA     --- --- --- --- --- --- 

                                                                                                                             
                                             
                                             1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                              G   Q   A   H   Q   P   S   V   Y   V   L   P   P   S   R   E 
  IMGT000001   IGHG2*01 F   CH3-CHS gDNA                     ggg cag gcc cat caa ccc agt gtg tat gtc ctg ccg cca tcc cgg gag

                                                                                                                            
  AAEX03006126 IGHG2*01 F   CH3-CHS gDNA                      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                            
  AF354265     IGHG2*02 (F) CH3-CHS cDNA                     --- --a --- --- --g --- --- --- --- --- --- --- --- --- --- ---



                                                         _____AB_____                                            ____________
                                                         15.1    15.3                                                        
                                              13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                              E   L   S               K   N   T   V   S   L   T   C   L   I   K   D   F   F 
  IMGT000001   IGHG2*01 F   CH3-CHS gDNA     gag ttg agc ... ... ... aag aac aca gtc agc ttg aca tgc ctg atc aaa gac ttc ttc

                                                                                                                            
  AAEX03006126 IGHG2*01 F   CH3-CHS gDNA     --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                            
  AF354265     IGHG2*02 (F) CH3-CHS cDNA     --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                             _______BC___________________                            _____________CD_________
                                                                                                     45.1    45.3    45.5    
                                              30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                              P           P   D   I   D   V   E   W   Q   S   N   G   Q   Q   E   P   E   S 
  IMGT000001   IGHG2*01 F   CH3-CHS gDNA     cca ... ... cct gac att gat gtg gag tgg cag agc aat gga cag cag gag cct gag agc

                                                                                                                            
  AAEX03006126 IGHG2*01 F   CH3-CHS gDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                                                                                            
  AF354265     IGHG2*02 (F) CH3-CHS cDNA     --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                             ____                                ___________________________DE_______________
                                             45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                                  77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                                  K   Y   R   T   T   P   P   Q   L   D   E   D                           G 
  IMGT000001   IGHG2*01 F   CH3-CHS gDNA     ... aag tac cgc acg acc ccg ccc cag ctg gac gag gac ... ... ... ... ... ... ggg

                                                                                                                            
  AAEX03006126 IGHG2*01 F   CH3-CHS gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---

                                                                                                                            
  AF354265     IGHG2*02 (F) CH3-CHS cDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---



                                             ____________                                                ___EF___            
                                                 85.2                                                    96.1                
                                             85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                              S   Y   F   L   Y   S   K   L   S   V   D   K   S   R   W           Q   R   G 
  IMGT000001   IGHG2*01 F   CH3-CHS gDNA     tcc tac ttc ctg tac agc aag ctc tct gtg gac aag agc cgc tgg ... ... cag cgg gga

                                                                                                                            
  AAEX03006126 IGHG2*01 F   CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---

                                                                                                                            
  AF354265     IGHG2*02 (F) CH3-CHS cDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---



                                                                 _________________________FG_________________________        
                                             
                                             100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                              D   T   F   I   C   A   V   M   H   E   A       L   H   N   H   Y   T   Q   K 
  IMGT000001   IGHG2*01 F   CH3-CHS gDNA     gac acc ttc ata tgt gcg gtg atg cat gaa gct ... cta cac aac cac tac aca cag aaa

                                                                                                                            
  AAEX03006126 IGHG2*01 F   CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---

                                                                                                                          E 
  AF354265     IGHG2*02 (F) CH3-CHS cDNA     --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- g--



                                                                                 __CHS___
                                             
                                             120 121 122 123 124 125 126 127 128 129 130 
                                              S   L   S   H   S   P               G   K  
  IMGT000001   IGHG2*01 F   CH3-CHS gDNA     tcc ctc tcc cat tct ccg ... ... ... ggt aaa 

                                                                                         
  AAEX03006126 IGHG2*01 F   CH3-CHS gDNA     --- --- --- --- --- --- ... ... ... --- --- 

                                                                                         
  AF354265     IGHG2*02 (F) CH3-CHS cDNA     --- --- --- --- --- --- ... ... ... --- --- 

                                         
                                         
                                          1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                          E   L   I   L   D   D   S   C   A   E   D   Q   D   G   E   L   D   G   L   W 
  IMGT000001   IGHG2*01 F M1+M2 gDNA     gag ctg atc ctg gat gac agc tgt gct gag gac cag gac ggg gag ctg gac ggg ctg tgg

                                                                                                                        
  AAEX03006126 IGHG2*01 F M1+M2 gDNA      -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                         
                                         
                                          21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                          T   T   I   S   I   F   I   T   L   F   L   L   S   V   C   Y   S   A   T   V 
  IMGT000001   IGHG2*01 F M1+M2 gDNA     acc acc atc tcc atc ttc atc acc ctc ttc ctg ctc agc gtg tgc tac agc gcc act gtc

                                                                                                                        
  AAEX03006126 IGHG2*01 F M1+M2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                         
                                         
                                          41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                          T   L   F   K   V   K   W   I   F   S   S   V   V   E   L   K   R   T   I   V 
  IMGT000001   IGHG2*01 F M1+M2 gDNA     acc ctc ttc aag gtg aag tgg atc ttc tca tca gtg gtg gag ctg aag cgc acg att gtc

                                                                                                                        
  AAEX03006126 IGHG2*01 F M1+M2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---



                                         
                                         
                                          61  62  63  64  65  66  67  68  69  70  71 
                                          P   D   Y   R   N   M   I   G   Q   G   A  
  IMGT000001   IGHG2*01 F M1+M2 gDNA     ccc gac tac agg aat atg atc ggg cag ggg gcc 

                                                                                     
  AAEX03006126 IGHG2*01 F M1+M2 gDNA     --- --- --- --- --- --- --- --- --- --- --- 


This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux, Mehdi Yousfi and Perrine Pégorier).

Created:
05/05/2015
Last updated:
17/05/2018
Authors:
Géraldine Folch and Saida Hadi-Saljoqi