Here you are: IMGT Web resources > IMGT Repertoire > Proteins and alleles

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                
                                     
                                        1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                         A   S   P   T   S   P   K   V   F   P   L   S   L   C   S   T 
  J00220   IGHA1*01   F   CH1 gDNA                      gca tcc ccg acc agc ccc aag gtc ttc ccg ctg agc ctc tgc agc acc
                                                                                                                    
  AF067420 IGHA1*01   F   CH1 cDNA (S)                  --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          Q   P                   D   G   N   V   V   I   A   C   L   V   Q   G   F   F 
  J00220   IGHA1*01   F   CH1 gDNA       cag cca ... ... ... ... gat ggg aac gtg gtc atc gcc tgc ctg gtc cag ggc ttc ttc
                                                                                                                    
  AF067420 IGHA1*01   F   CH1 cDNA  (S)  --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                        _______BC___________________                            _____________CD_________
                                                                                                45.1    45.3    45.5    
                                         30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                         P   Q       E   P   L   S   V   T   W   S   E   S   G   Q   G   V             
  J00220   IGHA1*01   F   CH1 gDNA      ccc cag ... gag cca ctc agt gtg acc tgg agc gaa agc gga cag ggc gtg ... ... ...
                                                                                                                    
  AF067420 IGHA1*01   F   CH1 cDNA (S)  --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                        ____                                ___________________________DE_______________
                                        45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                             77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                             T   A   R   N   F   P   P   S   Q   D   A   S   G                       D 
  J00220   IGHA1*01   F   CH1 gDNA      ... acc gcc aga aac ttc cca ccc agc cag gat gcc tcc ggg ... ... ... ... ... gac
                                                                                                                    
  AF067420 IGHA1*01   F   CH1 cDNA (S)  ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---


                                        ____________                                                ___EF___            
                                            85.2                                                    96.1                
                                        85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                         L   Y   T   T   S   S   Q   L   T   L   P   A   T   Q   C           L   A   G 
  J00220   IGHA1*01   F   CH1 gDNA      ctg tac acc acg agc agc cag ctg acc ctg ccg gcc aca cag tgc ... ... cta gcc ggc
                                                                                                                    
  AF067420 IGHA1*01   F   CH1 cDNA (S)  --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                             _________________________FG_________________________        
                                        
                                        100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                         K   S   V   T   C   H   V   K   H   Y               T   N   P   S   Q   D   V 
  J00220   IGHA1*01   F   CH1 gDNA      aag tcc gtg aca tgc cac gtg aag cac tac ... ... ... acg aat ccc agc cag gat gtg
                                                                                                                    
  AF067420 IGHA1*01   F   CH1 cDNA  (S) --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- ---


                                                            
                                        
                                        120 121 122 123 124 
                                         T   V   P   C   P  
  J00220   IGHA1*01   F   CH1 gDNA      act gtg ccc tgc cca 
                                                         
  AF067420 IGHA1*01   F   CH1 cDNA (S)  --- --- --- --- --- 




                                       ------------------->----------->------------------->--------------------->(1)
                                       1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19 
  J00220   IGHA1*01   F   H gDNA      gtt ccc tca act cca cct acc cca tct ccc tca act cca cct acc cca tct ccc tca
                                                                                                                      
  AF067420 IGHA1*01   F   H cDNA (S)  --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

  AL928768 IGHA1*02   F   H gDNA      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 




                                      

                                       
                                       
                                        1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                                 C   C   H   P   R   L   S   L   H   R   P   A   L   E   
  J00220   IGHA1*01   F   CH2 gDNA                              tgc tgc cac ccc cga ctg tca ctg cac cga ccg gcc ctc gag  
                                                                                                                      
  AF067420 IGHA1*01   F   CH2 cDNA  (S)                         --- --- --- --- --- --- --- --- --- --- --- --- --- ---  

  AL928768 IGHA1*02   F   CH2 gDNA                              --- --- --- --- --- --- --- --- --- --- --- --- --- ---  

                                       
                                       
                                       
                                                    _____AB_____                                            ____________
                                                    15.1    15.3                                                        
                                         13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29                                      
                                         D   L   L   L           G   S   E   A   N   L   T   C   T   L   T   G   L   R       
  J00220   IGHA1*01   F   CH2 gDNA      gac ctg ctc tta ... ... ggt tca gaa gcg aac ctc acg tgc aca ctg acc ggc ctg aga  
                                                                                                                      
  AF067420 IGHA1*01   F   CH2 cDNA (S)  --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

  AL928768 IGHA1*02   F   CH2 gDNA      --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                       
                                       
                                       
                                        _______BC___________________                            _____________CD_________
                                                                                                45.1    45.3    45.5    
                                         30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6                                     
                                         D   A       S   G   V   T   F   T   W   T   P   S   S   G   K   S                                        
  J00220   IGHA1*01   F   CH2 gDNA      gat gcc ... tca ggt gtc acc ttc acc tgg acg ccc tca agt ggg aag agc ... ... ...  
                                                                                                                      
  AF067420 IGHA1*01   F   CH2 cDNA (S)  --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...  

  AL928768 IGHA1*02   F   CH2 gDNA      --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...  


                                       
                                       
                                        ____                                ___________________________DE_______________
                                        45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                             77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5                                           
                                             A   V   Q   G   P   P   E   R   D   L   C   G                                 
  J00220   IGHA1*01   F   CH2 gDNA      ... gct gtt caa gga cca cct gag cgt gac ctc tgt ggc ... ... ... ... ... ... ... 
                                                                                                                      
  AF067420 IGHA1*01   F   CH2 cDNA (S)  ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...  

  AL928768 IGHA1*02   F   CH2 gDNA      ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...  


                                       
                                       
                                        ____________                                                ___EF___            
                                            85.2                                                    96.1                
                                        85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99                                       
                                         C   Y   S   V   S   S   V   L   P   G   C   A   E   P   W           N   H   G                
  J00220   IGHA1*01   F   CH2 gDNA      tgc tac agc gtg tcc agt gtc ctg ccg ggc tgt gcc gag cca tgg ... ... aac cat ggg   
                                                                                                                      
  AF067420 IGHA1*01   F   CH2 cDNA (S)  --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---   

  AL928768 IGHA1*02   F   CH2 gDNA      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---   


                                       
                                       
                                                            _________________________FG________________________        
                                           
                                        100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119                                      
                                         K   T   F   T   C   T   A   A   Y   P   E           S   K   T   P   L   T   A       
  J00220   IGHA1*01   F   CH2 gDNA      aag acc ttc act tgc act gc tgcc tac ccc gag ... ... tcc aag acc ccg cta acc gcc       
                                                                                                                      
  AF067420 IGHA1*01   F   CH2 cDNA (S)  --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---  

  AL928768 IGHA1*02   F   CH2 gDNA      --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---  

 
 
 
                                        120 121 122 123 124
                                         T   L   S   K   S  
  J00220   IGHA1*01   F   CH2 gDNA      acc ctc tca aaa tcc
                                                                                                                      
  AF067420 IGHA1*01   F   CH2 cDNA (S)  --- --- --- --- ---

  AL928768 IGHA1*02   F   CH2 gDNA      --- --- --- --- ---




                                                                                                                            
                                            
                                            1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                             G   N   T   F   R   P   E   V   H   L   L   P   P   P   S   E 
  J00220   IGHA1*01   F   CH3-CHS gDNA                      gga aac aca ttc cgg ccc gag gtc cac ctg ctg ccg ccg ccg tcg gag
                                                                                                                        
  AF067420 IGHA1*01   F   CH3-CHS cDNA (S)                  --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

  AL928768 IGHA1*02   F   CH3-CHS gDNA                      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                        _____AB_____                                            ____________
                                                        15.1    15.3                                                        
                                             13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                             E   L   A   L           N   E   L   V   T   L   T   C   L   A   R   G   F   S 
  J00220   IGHA1*01   F   CH3-CHS gDNA      gag ctg gcc ctg ... ... aac gag ctg gtg acg ctg acg tgc ctg gca cgc ggc ttc agc
                                                                                                                        
  AF067420 IGHA1*01   F   CH3-CHS cDNA (S)  --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---

  AL928768 IGHA1*02   F   CH3-CHS gDNA      --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _______BC___________________                            _____________CD_________
                                                                                                    45.1    45.3    45.5    
                                             30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                             P           K   D   V   L   V   R   W   L   Q   G   S   Q   E   L   P   R   E 
  J00220   IGHA1*01   F   CH3-CHS gDNA      ccc ... ... aag gac gtg ctg gtt cgc tgg ctg cag ggg tca cag gag ctg ccc cgc gag
                                                                                                                        
  AF067420 IGHA1*01   F   CH3-CHS cDNA (S)  --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

  AL928768 IGHA1*02   F   CH3-CHS gDNA      --- ... ... --- --t --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            ____                                ___________________________DE_______________
                                            45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                                 77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                                 K   Y   L   T   W   A   S   R   Q   E   P   S   Q   G               T   T 
  J00220   IGHA1*01   F   CH3-CHS gDNA      ... aag tac ctg act tgg gca tcc cgg cag gag ccc agc cag ggc ... ... ... acc acc
                                                                                                                           
  AF067420 IGHA1*01   F   CH3-CHS cDNA (S)  ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---

  AL928768 IGHA1*02   F   CH3-CHS gDNA      ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                            ____________                                                ___EF___            
                                                85.2                                                    96.1                
                                            85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                             T   F   A   V   T   S   I   L   R   V   A   A   E   D   W           K   K   G 
  J00220   IGHA1*01   F   CH3-CHS gDNA      acc ttc gct gtg acc agc ata ctg cgc gtg gca gcc gag gac tgg ... ... aag aag ggg
                                                                                                                        
  AF067420 IGHA1*01   F   CH3-CHS cDNA (S)  --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---

  AL928768 IGHA1*02   F   CH3-CHS gDNA      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                                _________________________FG_________________________        
                                            
                                            100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                             D   T   F   S   C   M   V   G   H   E   A       L   P   L   A   F   T   Q   K 
  J00220   IGHA1*01   F   CH3-CHS gDNA      gac acc ttc tcc tgc atg gtg ggc cac gag gcc ... ctg ccg ctg gcc ttc aca cag aag
                                                                                                                           
  AF067420 IGHA1*01   F   CH3-CHS cDNA (S)  --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---

  AL928768 IGHA1*02   F   CH3-CHS gDNA      --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                                ______________________________________CHS___
                                            
                                            120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                             T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  J00220   IGHA1*01   F   CH3-CHS gDNA      acc atc gac cgc ttg gcg ... ... ... ggt aaa ccc acc cat gtc aat gtg tct gtt gtc
                                                                                                                        
  AF067420 IGHA1*01   F   CH3-CHS cDNA (S)  --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---

  AL928768 IGHA1*02   F   CH3-CHS gDNA      --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---


                                            ____________________________________
                                            
                                            140 141 142 143 144 145 146 147 148 
                                             M   A   E   V   D   G   T   C   Y  
  J00220   IGHA1*01   F   CH3-CHS gDNA      atg gcg gag gtg gac ggc acc tgc tac 
                                                                             
  AF067420 IGHA1*01   F   CH3-CHS cDNA (S)  --- --- --- --- --- --- --- --- --- 

  AL928768 IGHA2*02   F   CH3-CHS gDNA      --- --- --- --- --- --- --- --- --- 




                                   
                                   
                                       1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                       G   S   C   S   V   A   D   W   Q   M   P   P   P   Y   V   V   L   D   L   P 
  M60193   IGHA1*01   F   M gDNA      ggc tct tgc tct gtt gca gat tgg cag atg ccg cct ccc tat gtg gtg ctg gac ttg ccg
                                                   C
  AL928768 IGHA1*02   F   M gDNA      --- --- --- -g- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                       21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                       Q   E   T   L   E   E   E   T   P   G   A   N   L   W   P   T   T   I   T   F 
  M60193   IGHA1*01   F   M gDNA      cag gag acc ctg gag gag gag acc ccc ggc gcc aac ctg tgg ccc acc acc atc acc ttc

  AL928768 IGHA1*02   F   M gDNA      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                       41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                       L   T   L   F   L   L   S   L   F   Y   S   T   A   L   T   V   T   S   V   R 
  M60193   IGHA1*01   F   M gDNA      ctc acc ctc ttc ctg ctg agc ctg ttc tat agc aca gca ctg acc gtg acc agc gtc cgg

  AL928768 IGHA1*02   F   M gDNA      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                       61  62  63  64  65  66  67  68  69  70  71 
                                       G   P   S   G   N   R   E   G   P   Q   Y  
  M60193   IGHA1*01   F   M gDNA      ggc cca tct ggc aac agg gag ggc ccc cag tac 

  AL928768 IGHA1*02   F   M gDNA      --- --- --- --- --- --- --- --- --- --- --- 
 



  
  
(s): transcript of a secreted chain.

IMGT notes:

(1) Arrows show the repetitive structure of the IGHA1 hinge as described in Flanagan, J.G. et al., Cell, 36, 681-688 (1984).

(2) In the IGHA gene, the hinge (H) and the (CH2) are joined in a single exon.



This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
20/01/1999
Last updated:
27/05/2016
Authors:
Saida Saljoqi, Christèle Martinez-Jean and Nathalie Bosc