Here you are: IMGT Web resources > IMGT Repertoire > Proteins and alleles

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                      A   S   P   T   S   P   K   V   F   P   L   S   L   D   S   T 
  J00221   IGHA2*01   F   CH1 gDNA                   gca tcc ccg acc agc ccc aag gtc ttc ccg ctg agc ctc gac agc acc
                                                                                                                    
  M60192   IGHA2*02   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHA2*02   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  S71043   IGHA2*03   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      P   Q                   D   G   N   V   V   V   A   C   L   V   Q   G   F   F 
  J00221   IGHA2*01   F   CH1 gDNA   ccc caa ... ... ... ... gat ggg aac gtg gtc gtc gca tgc ctg gtc cag ggc ttc ttc
                                                                                                                    
  M60192   IGHA2*02   F   CH1 gDNA   --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHA2*02   F   CH1 gDNA   --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  S71043   IGHA2*03   F   CH1 gDNA   --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      P   Q       E   P   L   S   V   T   W   S   E   S   G   Q   N   V             
  J00221   IGHA2*01   F   CH1 gDNA   ccc cag ... gag cca ctc agt gtg acc tgg agc gaa agc gga cag aac gtg ... ... ...
                                                                                                                    
  M60192   IGHA2*02   F   CH1 gDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                    
  AL928742 IGHA2*02   F   CH1 gDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                    
  S71043   IGHA2*03   F   CH1 gDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          T   A   R   N   F   P   P   S   Q   D   A   S   G                       D 
  J00221   IGHA2*01   F   CH1 gDNA   ... acc gcc aga aac ttc cca cct agc cag gat gcc tcc ggg ... ... ... ... ... gac
                                                                                                                    
  M60192   IGHA2*02   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
                                                                                                                    
  AL928742 IGHA2*02   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
                                                                                                                    
  S71043   IGHA2*03   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      L   Y   T   T   S   S   Q   L   T   L   P   A   T   Q   C           P   D   G 
  J00221   IGHA2*01   F   CH1 gDNA   ctg tac acc acg agc agc cag ctg acc ctg ccg gcc aca cag tgc ... ... cca gac ggc
                                                                                                                    
  M60192   IGHA2*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  AL928742 IGHA2*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  S71043   IGHA2*03   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   S   V   T   C   H   V   K   H   Y               T   N   P   S   Q   D   V 
  J00221   IGHA2*01   F   CH1 gDNA   aag tcc gtg aca tgc cac gtg aag cac tac ... ... ... acg aat ccc agc cag gat gtg
                                                                                                  S                 
  M60192   IGHA2*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- t-- --- --- --- ---
                                                                                                  S                 
  AL928742 IGHA2*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- t-- --- --- --- ---
                                                                                                  S                 
  S71043   IGHA2*03   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- t-- --- --- --- ---


                                                         
                                     
                                     120 121 122 123 124 
                                      T   V   P   C   P  
  J00221   IGHA2*01   F   CH1 gDNA   act gtg ccc tgc cca 
                                                      R  
  M60192   IGHA2*02   F   CH1 gDNA   --- --- --- --- -g- 
                                                      R  
  AL928742 IGHA2*02   F   CH1 gDNA   --- --- --- --- -g- 
                                                      R  
  S71043   IGHA2*03   F   CH1 gDNA   --- --- --- --- -g- 




                                             --------------------->(1)
                                             1   2   3   4   5   6  
                                             V   P   P   P   P   P  
  J00221   IGHA2*01   F   H  gDNA           gtt ccc cca cct ccc cca 
                                                        
  M60192   IGHA2*02   F   H  gDNA           --- --- --- --- --- --- 
                                                        
  S71043   IGHA2*03   F   H  gDNA           --- --- --- --- --- --- 



                                       
                                       
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                              C   C   H   P   R   L   S   L   H   R   P   A   L   E 
  J00221   IGHA2*01   F   CH2 gDNA                           tgc tgc cac ccc cga ctg tcg ctg cac cga ccg gcc ctc gag
                                                                                                                      
  M60192   IGHA2*02   F   CH2 gDNA                           --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                      
  AL928742 IGHA2*02   F   CH2 gDNA                           --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                      
  S71043   IGHA2*03   F   CH2 gDNA                           --- --- --- --- --- --- --- --- --- --- --- --- --- --- 


                                       
                                       
                                                  _____AB_____                                            ____________
                                                  15.1    15.3                                                        
                                       13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29                                      
                                       D   L   L   L           G   S   E   A   N   L   T   C   T   L   T   G   L   R
  J00221   IGHA2*01   F   CH2 gDNA    gac ctg ctc tta ... ... ggt tca gaa gcg aac ctc acg tgc aca ctg acc ggc ctg aga
                                                                                                                      
  M60192   IGHA2*02   F   CH2 gDNA    --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                      
  AJ012264 IGHA2*02   F   CH2 gDNA                    ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                      
  AL928742 IGHA2*02   F   CH2 gDNA    --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                      
  S71043   IGHA2*03   F   CH2 gDNA    --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                       
                                       
                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6                                     
                                      D   A       S   G   A   T   F   T   W   T   P   S   S   G   K   S  
  J00221   IGHA2*01   F   CH2 gDNA   gat gcc ... tct ggt gcc acc ttc acc tgg acg ccc tca agt ggg aag agc ... ... ...
                                                                                       
  M60192   IGHA2*02   F   CH2 gDNA   --- --- ... --- --- --- -
                                                                                                                      
  AJ012264 IGHA2*02   F   CH2 gDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                      
  AL928742 IGHA2*02   F   CH2 gDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                      
  S71043   IGHA2*03   F   CH2 gDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                       
                                       
                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5                                           
                                          A   V   Q   G   P   P   E   R   D   L   C   G 
  J00221   IGHA2*01   F   CH2 gDNA   ... gct gtt caa gga cca cct gag cgt gac ctc tgt ggc ... ... ... ... ... ... ... 
                                                                                                                      
  AJ012264 IGHA2*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
                                                                                                                      
  AL928742 IGHA2*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
                                                                                                                      
  S71043   IGHA2*03   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...


                                       
                                       
                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99                                       
                                      C   Y   S   V   S   S   V   L   P   G   C   A   Q   P   W           N   H   G 
  J00221   IGHA2*01   F   CH2 gDNA   tgc tac agc gtg tcc agt gtc ctg cct ggc tgt gcc cag cca tgg ... ... aac cat ggg
                                                                                                                      
  AJ012264 IGHA2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                      
  AL928742 IGHA2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                      
  S71043   IGHA2*03   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                       
                                       
                                                         _________________________FG________________________        
                                           
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119                                      
                                      E   T   F   T   C   T   A   A   H   P   E           L   K   T   P   L   T   A 
  J00221   IGHA2*01   F   CH2 gDNA   gag acc ttc acc tgc act gct gcc cac ccc gag ... ... ttg aag acc cca cta acc gcc
                                                                                                                      
  AJ012264 IGHA2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                      
  AL928742 IGHA2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                      
  S71043   IGHA2*03   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                       
                                       
                                                     
                                      
                                     120 121 122 123 124 
                                      N   I   T   K   S  
  J00221   IGHA2*01   F   CH2 gDNA   aac atc aca aaa tcc 
                                                                                   
  AJ012264 IGHA2*02   F   CH2 gDNA   --- --- --- --- --- 
                                                                                   
  AL928742 IGHA2*02   F   CH2 gDNA   --- --- --- --- --- 
                                                                                   
  S71043   IGHA2*03   F   CH2 gDNA   --- --- --- --- --- 






                                                                                                                        
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          G   N   T   F   R   P   E   V   H   L   L   P   P   P   S   E 
  J00221   IGHA2*01   F   CH3-CHS gDNA                   gga aac aca ttc cgg ccc gag gtc cac ctg ctg ccg ccg ccg tcg gag
                                                                                                                        
  AJ012264 IGHA2*02   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AL928742 IGHA2*02   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  S71043   IGHA2*03   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          E   L   A   L           N   E   L   V   T   L   T   C   L   A   R   G   F   S 
  J00221   IGHA2*01   F   CH3-CHS gDNA   gag ctg gcc ctg ... ... aac gag ctg gtg acg ctg acg tgc ctg gca cgt ggc ttc agc
                                                                                                                        
  AJ012264 IGHA2*02   F   CH3-CHS gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AL928742 IGHA2*02   F   CH3-CHS gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  S71043   IGHA2*03   F   CH3-CHS gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           K   D   V   L   V   R   W   L   Q   G   S   Q   E   L   P   R   E 
  J00221   IGHA2*01   F   CH3-CHS gDNA   ccc ... ... aag gat gtg ctg gtt cgc tgg ctg cag ggg tca cag gag ctg ccc cgc gag
                                                                                                                        
  AJ012264 IGHA2*02   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AL928742 IGHA2*02   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  S71043   IGHA2*03   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              K   Y   L   T   W   A   S   R   Q   E   P   S   Q   G               T   T 
  J00221   IGHA2*01   F   CH3-CHS gDNA   ... aag tac ctg act tgg gca tcc cgg cag gag ccc agc cag ggc ... ... ... acc acc
                                                                                                                        
  AJ012264 IGHA2*02   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
                                                                                                                        
  AL928742 IGHA2*02   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
                                                                                                                        
  S71043   IGHA2*03   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          T   F   A   V   T   S   I   L   R   V   A   A   E   D   W           K   K   G 
  J00221   IGHA2*01   F   CH3-CHS gDNA   acc ttc gct gtg acc agc ata ctg cgc gtg gca gcc gag gac tgg ... ... aag aag ggg
                                              Y                                                                         
  AJ012264 IGHA2*02   F   CH3-CHS gDNA   --- -a- --- --a --- --- --- --- --- --- --- --t --- --- --- ... ... --- --- ---
                                              Y                                                                         
  AL928742 IGHA2*02   F   CH3-CHS gDNA   --- -a- --- --a --- --- --- --- --- --- --- --t --- --- --- ... ... --- --- ---
                                                                                                                        
  S71043   IGHA2*03   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          D   T   F   S   C   M   V   G   H   E   A       L   P   L   A   F   T   Q   K 
  J00221   IGHA2*01   F   CH3-CHS gDNA   gac acc ttc tcc tgc atg gtg ggc cac gag gcc ... ctg ccg ctg gcc ttc aca cag aag
                                          E                                                                             
  AJ012264 IGHA2*02   F   CH3-CHS gDNA   --g --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                          E                                                                             
  AL928742 IGHA2*02   F   CH3-CHS gDNA   --g --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                        
  S71043   IGHA2*03   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                             ______________________________________CHS___
                                         
                                         120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                          T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  J00221   IGHA2*01   F   CH3-CHS gDNA   acc atc gac cgc ttg gcg ... ... ... ggt aaa ccc acc cat gtc aat gtg tct gtt gtc
                                                          M                                       I                     
  AJ012264 IGHA2*02   F   CH3-CHS gDNA   --- --- --- --- a-- --- ... ... ... --- --- --- --- --c a-- --- --- --- --- ---
                                                          M                                       I                     
  AL928742 IGHA2*02   F   CH3-CHS gDNA   --- --- --- --- a-- --- ... ... ... --- --- --- --- --c a-- --- --- --- --- ---
                                                                                                                        
  S71043   IGHA2*03   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---


                                         ____________________________________
                                         
                                         140 141 142 143 144 145 146 147 148 
                                          M   A   E   V   D   G   T   C   Y  
  J00221   IGHA2*01   F   CH3-CHS gDNA   atg gcg gag gtg gac ggc acc tgc tac 
                                                      A                      
  AJ012264 IGHA2*02   F   CH3-CHS gDNA   --- --- --- -c- --t --- --- --- --- 
                                                      A                      
  AL928742 IGHA2*02   F   CH3-CHS gDNA   --- --- --- -c- --t --- --- --- --- 
                                                                             
  S71043   IGHA2*03   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- 




                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                    G   S   C   C   V   A   D   W   Q   M   P   P   P   Y   V   V   L   D   L   P 
  M60194   IGHA2*02   F   M gDNA   ggc tct tgc tgt gtt gca gat tgg cag atg ccg cct ccc tat gtg gtg ctg gac ttg ccg
                                                                                                                  
  AL928742 IGHA2*02   F   M gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                    Q   E   T   L   E   E   E   T   P   G   A   N   L   W   P   T   T   I   T   F 
  M60194   IGHA2*02   F   M gDNA   cag gag acc ctg gag gag gag acc ccc ggc gcc aac ctg tgg ccc acc acc atc acc ttc
                                                                                                                  
  AL928742 IGHA2*02   F   M gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                    L   T   L   F   L   L   S   L   F   Y   S   T   A   L   T   V   T   S   V   R 
  M60194   IGHA2*02   F   M gDNA   ctc acc ctc ttc ctg ctg agc ctg ttc tat agc aca gca ctg acc gtg acc agc gtc cgg
                                                                                                                  
  AL928742 IGHA2*02   F   M gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    61  62  63  64  65  66  67  68  69  70  71 
                                    G   P   S   G   K   R   E   G   P   Q   Y  
  M60194   IGHA2*02   F   M gDNA   ggc cca tct ggc aag agg gag ggc ccc cag tac 
                                                                               
  AL928742 IGHA2*02   F   M gDNA   --- --- --- --- --- --- --- --- --- --- --- 





IMGT notes:

(1) Arrows show the repetitive structure of the IGHA1 hinge as described in Flanagan, J.G. et al., Cell, 36, 681-688 (1984).

(2) In the IGHA gene, the hinge (H) and the (CH2) are joined in a single exon.



This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
20/01/1999
Last updated:
27/05/2016
Authors:
Saida Saljoqi, Christèle Martinez-Jean and Nathalie Bosc