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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                
                                    
                                    1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                     A   P   T   K   A   P   D   V   F   P   I   I   S   G   C   R 
  K02875   IGHD*01   F   CH1 gDNA                   gca ccc acc aag gct ccg gat gtg ttc ccc atc ata tca ggg tgc aga
                                                                                                                   
  X57331   IGHD*02   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                _____AB_____                                            ____________
                                                15.1    15.3                                                        
                                     13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                     H   P   K   D           N   S   P   V   V   L   A   C   L   I   T   G   Y   H 
  K02875   IGHD*01   F   CH1 gDNA   cac cca aag gat ... ... aac agc cct gtg gtc ctg gca tgc ttg ata act ggg tac cac
                                                                                                                   
  X57331   IGHD*02   F   CH1 gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    _______BC___________________                            _____________CD_________
                                                                                            45.1    45.3    45.5    
                                     30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                     P           T   S   V   T   V   T   W   Y   M   G   T   Q   S   Q             
  K02875   IGHD*01   F   CH1 gDNA   cca ... ... acg tcc gtg act gtc acc tgg tac atg ggg aca cag agc cag ... ... ...
                                                                                                                   
  X57331   IGHD*02   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                    ____                                ___________________________DE_______________
                                    45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                         77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                         P   Q   R   T   F   P   E   I   Q   R   R   D                           S 
  K02875   IGHD*01   F   CH1 gDNA   ... ccc cag aga acc ttc cct gag ata caa aga cgg gac ... ... ... ... ... ... agc
                                                                                                                   
  X57331   IGHD*02   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                    ____________                                                ___EF___            
                                        85.2                                                    96.1                
                                    85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                     Y   Y   M   T   S   S   Q   L   S   T   P   L   Q   Q   W               R   Q 
  K02875   IGHD*01   F   CH1 gDNA   tac tac atg aca agc agc cag ctc tcc acc ccc ctc cag cag tgg ... ... ... cgc caa
                                                                                                                   
  X57331   IGHD*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                                        _________________________FG_________________________        
                                    
                                    100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                     G   E   Y   K   C   V   V   Q   H   T               A   S   K   S   K   K   E 
  K02875   IGHD*01   F   CH1 gDNA   ggc gag tac aaa tgc gtg gtc cag cac acc ... ... ... gcc agc aag agt aag aag gag
                                                                                                                   
  X57331   IGHD*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- ---


                                                        
                                    
                                    120 121 122 123 124 
                                     I   F   R   W   P  
  K02875   IGHD*01   F   CH1 gDNA   atc ttc cgc tgg cca 
                                                        
  X57331   IGHD*02   F   CH1 gDNA   --- --- --- --- --- 
                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                    E   S   P   K   A   Q   A   S   S   V   P   T   A   Q   P   Q   A   E   G   S 
  K02876   IGHD*01   F   H1 gDNA   gag tct cca aag gca cag gcc tcc tcc gtg ccc act gca caa ccc caa gca gag ggc agc
                                                                                                                  
  X57331   IGHD*02   F   H1 gDNA   --- --- --- --- --- --- --- --- --a --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    21  22  23  24  25  26  27  28  29  30  31  32  33  34 
                                    L   A   K   A   T   T   A   P   A   T   T   R   N   T  
  K02876   IGHD*01   F   H1 gDNA   ctc gcc aag gca acc aca gcc cca gcc acc acc cgt aac aca g
                                                                                           
  X57331   IGHD*02   F   H1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- ---  
                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                    G   R   G   G   E   E   K   K   K   E   K   E   K   E   E   Q   E   E   R   E 
  K02877   IGHD*01   F   H2 gDNA   gga aga gga gga gaa gag aag aag aag gag aag gag aaa gag gaa caa gaa gag aga gag
                                                                                                                  
  X57331   IGHD*02   F   H2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    21  22  23  24 
                                    T   K   T   P  
  K02877   IGHD*01   F   H2 gDNA   aca aag aca cca g
                                                   
  X57331   IGHD*02   F   H2 gDNA   --- --- --- ---  
                                                                                                                    
                                    
                                    1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                         E   C   P   S   H   T   Q   P   L   G   V   Y   L   L   T   P   A   V   Q 
  K02878   IGHD*01   F   CH2 gDNA       gag tgt ccg agc cac acc cag cct ctt ggc gtc tac ctg cta acc cct gca gtg cag
                                                                                                                   
  X57331   IGHD*02   F   CH2 gDNA       --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                _____AB_____                                            ____________
                                                15.1    15.3                                                        
                                     13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                     D   L   W   L           R   D   K   A   T   F   T   C   F   V   V   G   S   D 
  K02878   IGHD*01   F   CH2 gDNA   gac ctg tgg ctc ... ... cgg gac aaa gcc acc ttc acc tgc ttc gtg gtg ggc agt gac
                                                                                                                   
  X57331   IGHD*02   F   CH2 gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    _______BC___________________                            _____________CD_________
                                                                                            45.1    45.3    45.5    
                                     30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                     L           K   D   A   H   L   T   W   E   V   A   G   K   V   P   T   G     
  K02878   IGHD*01   F   CH2 gDNA   ctg ... ... aag gat gct cac ctg acc tgg gag gtg gct ggg aag gtc ccc aca ggg ...
                                                                                                                   
  X57331   IGHD*02   F   CH2 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...


                                    ____                                ___________________________DE_______________
                                    45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                         77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                         G   V   E   E   G   L   L   E   R   H   S   N                           G 
  K02878   IGHD*01   F   CH2 gDNA   ... ggc gtg gag gaa ggg ctg ctg gag cgg cac agc aac ... ... ... ... ... ... ggc
                                                                                                                   
  X57331   IGHD*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                    ____________                                                ___EF___            
                                        85.2                                                    96.1                
                                    85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                     S   Q   S   Q   H   S   R   L   T   L   P   R   S   L   W           N   A   G 
  K02878   IGHD*01   F   CH2 gDNA   tcc cag agc cag cac agc cgt ctg acc ctg ccc agg tcc ttg tgg ... ... aac gcg ggg
                                                                                                                   
  X57331   IGHD*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                        _________________________FG_________________________        
                                    
                                    100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                     T   S   V   T   C   T   L   N   H   P   S           L   P   P   Q   R   L   M 
  K02878   IGHD*01   F   CH2 gDNA   acc tcc gtc acc tgc aca ctg aac cat ccc agc ... ... ctc cca ccc cag agg ttg atg
                                                                                                                   
  X57331   IGHD*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                        
                                    
                                    120 121 122 123 124 
                                     A   L   R   E   P  
  K02878   IGHD*01   F   CH2 gDNA   gcg ctg aga gaa ccc 
                                                        
  X57331   IGHD*02   F   CH2 gDNA   --- --- --- --- --- 
                                                                                                                    
                                    
                                    1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                         A   A   Q   A   P   V   K   L   S   L   N   L   L   A   S 
  K02879   IGHD*01   F   CH3 gDNA                       gct gcg cag gca ccc gtc aag ctt tct ctg aac ctg ctg gcc tcg
                                                                                                                   
  X57331   IGHD*02   F   CH3 gDNA                       --- --- --- --- --- --- --- --- --c --- --- --- --- --- ---


                                                _____AB_____                                            ____________
                                                15.1    15.3                                                        
                                     13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                     S   D   P   P           E   A   A   S   W   L   L   C   E   V   S   G   F   S 
  K02879   IGHD*01   F   CH3 gDNA   tct gac cct ccc ... ... gag gcg gcc tcg tgg ctc ctg tgt gag gtg tct ggc ttc tcg
                                                                                                                   
  X57331   IGHD*02   F   CH3 gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    _______BC___________________                            _____________CD_________
                                                                                            45.1    45.3    45.5    
                                     30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                     P           P   N   I   L   L   M   W   L   E   D   Q   R   E   V   N   T   S 
  K02879   IGHD*01   F   CH3 gDNA   ccc ... ... ccc aac atc ctc ctg atg tgg ctg gag gac cag cgt gag gtg aac act tct
                                                                                                                   
  X57331   IGHD*02   F   CH3 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    ____                                ___________________________DE_______________
                                    45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                         77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                         G   F   A   P   A   R   P   P   P   Q   P   R   S                       T 
  K02879   IGHD*01   F   CH3 gDNA   ... ggg ttt gcc ccc gca cgc ccc cct cca cag ccc agg agc ... ... ... ... ... acc
                                                                                                                   
  X57331   IGHD*02   F   CH3 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---


                                    ____________                                                ___EF___            
                                        85.2                                                    96.1                
                                    85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                     T   F   W   A   W   S   V   L   R   V   P   A   P   P   S           P   Q   P 
  K02879   IGHD*01   F   CH3 gDNA   acg ttc tgg gcc tgg agt gtg ctg cgt gtc cca gcc ccg ccc agc ... ... cct cag cca
                                                                                                                   
  X57331   IGHD*02   F   CH3 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                        _________________________FG_________________________        
                                    
                                    100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                     A   T   Y   T   C   V   V   S   H   E   D   S   R   T   L   L   N   A   S   R 
  K02879   IGHD*01   F   CH3 gDNA   gcc acc tac acg tgt gtg gtc agc cac gag gac tcc cgg act ctg ctc aac gcc agc cgg
                                                                                                                   
  X57331   IGHD*02   F   CH3 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                        
                                    
                                    120 121 122 123 124 
                                     S   L   E   V   S  
  K02879   IGHD*01   F   CH3 gDNA   agc cta gaa gtc agc 
                                                        
  X57331   IGHD*02   F   CH3 gDNA   --- --- --- --- --- 
                                    ________________CHS_________________
                                    
                                     1   2   3   4   5   6   7   8   9  
                                     Y   V   T   D   H   G   P   M   K  
  K02880   IGHD*01   F   CHS gDNA   tat gta aca gac cat ggc ccc atg aaa 
                                                                        
  X57331   IGHD*02   F   CHS gDNA   --- --- --- --- --- --- --- --- --- 
                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                    Y   L   A   M   T   P   L   I   P   Q   S   K   D   E   N   S   D   D   Y   T 
  K02881   IGHD*01   F   M1 gDNA   tac ctg gcc atg acc ccc ctg atc cct cag agc aag gat gag aac agc gat gac tac acg
                                                                                                                  
  X57331   IGHD*02   F   M1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                    T   F   D   D   V   G   S   L   W   T   T   L   S   T   F   V   A   L   F   I 
  K02881   IGHD*01   F   M1 gDNA   acc ttt gat gat gtg ggc agc ctg tgg acc acc ctg tcc acg ttt gtg gcc ctc ttc atc
                                                                                                                  
  X57331   IGHD*02   F   M1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    41  42  43  44  45  46  47  48  49  50  51  52  53 
                                    L   T   L   L   Y   S   G   I   V   T   F   I   K  
  K02881   IGHD*01   F   M1 gDNA   ctc acc ctc ctc tac agc ggc att gtc act ttc atc aag 
                                                                                       
  X57331   IGHD*02   F   M1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- 
                                   
                                   
                                    1   2  
                                    V   K  
  K02882   IGHD*01   F   M2 gDNA   gtg aag 
                                           
  X57331   IGHD*02   F   M2 gDNA   --- --- 

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
20/01/1999
Last updated:
27/05/2016
Authors:
Saida Saljoqi, Christèle Martinez-Jean and Nathalie Bosc