When several alleles are shown, the nucleotide mutations and amino acid
changes for a given codon are indicated in red letters. These polymorphic mutations are reported in
Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the
IMGT unique numbering.
Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.
The alleles IGHG1*05p (G1m17,1,28), IGHG1*06p (G1m17,1,27,28), IGHG1*07p (G1m17,1,2) and IGHG1*08p (G1m3,1), described in Lefranc and Lefranc [1], will be assigned with a definitive allele number (based on a chronological basis, and therefore unrelated to the provisional 'p' number) when a complete genomic sequence will be available.
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12 A S T K G P S V F P L A P S S K J00228 IGHG1*01 F CH1 gDNA gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag Z17370 IGHG1*02 F CH1 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- Y14737 IGHG1*03 (F) CH1 cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- JN582178 IGHG1*04 (F) CH1 cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH1 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- _____AB_____ ____________ 15.1 15.3 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29 S T S G G T A A L G C L V K D Y F J00228 IGHG1*01 F CH1 gDNA agc acc tct ... ... ... ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc Z17370 IGHG1*02 F CH1 gDNA --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- Y14737 IGHG1*03 (F) CH1 cDNA --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- JN582178 IGHG1*04 (F) CH1 cDNA --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH1 gDNA --- --- --- ... ... ... --- --- --- --a --- --- --- --- --- --- --- --- --- --- _______BC___________________ _____________CD_________ 45.1 45.3 45.5 30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6 P E P V T V S W N S G A L T S J00228 IGHG1*01 F CH1 gDNA ccc ... ... gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ... ... ... Z17370 IGHG1*02 F CH1 gDNA --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... Y14737 IGHG1*03 (F) CH1 cDNA --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... JN582178 IGHG1*04 (F) CH1 cDNA --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... AL122127 IGHG1*05 F CH1 gDNA --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ____ ___________________________DE_______________ 45.7 84.1 84.3 84.5 84.7 85.6 85.4 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5 G V H T F P A V L Q S S G J00228 IGHG1*01 F CH1 gDNA ... ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca ... ... ... ... ... ... gga Z17370 IGHG1*02 F CH1 gDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- Y14737 IGHG1*03 (F) CH1 cDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- JN582178 IGHG1*04 (F) CH1 cDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- AL122127 IGHG1*05 F CH1 gDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- ____________ ___EF___ 85.2 96.1 85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99 L Y S L S S V V T V P S S S L G T J00228 IGHG1*01 F CH1 gDNA ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ... ... ... ggc acc Z17370 IGHG1*02 F CH1 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- Y14737 IGHG1*03 (F) CH1 cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- JN582178 IGHG1*04 (F) CH1 cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- AL122127 IGHG1*05 F CH1 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- _________________________FG_________________________ 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 Q T Y I C N V N H K P S N T K V D K J00228 IGHG1*01 F CH1 gDNA cag acc tac atc tgc aac gtg aat cac aag ccc ... ... agc aac acc aag gtg gac aag Z17370 IGHG1*02 F CH1 gDNA --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- Y14737 IGHG1*03 (F) CH1 cDNA --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- JN582178 IGHG1*04 (F) CH1 cDNA --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH1 gDNA --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- 120 121 K V J00228 IGHG1*01 F CH1 gDNA aaa gtt Z17370 IGHG1*02 F CH1 gDNA --- --- R Y14737 IGHG1*03 (F) CH1 cDNA -g- --- JN582178 IGHG1*04 (F) CH1 cDNA --- --- AL122127 IGHG1*05 F CH1 gDNA --- ---
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
E P K S C D K T H T C P P C P
J00228 IGHG1*01 F H gDNA gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca
Z17370 IGHG1*02 F H gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Y14737 IGHG1*03 (F) H cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
JN582178 IGHG1*04 (F) H cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AL122127 IGHG1*05 F H gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12 A P E L L G G P S V F L F P P K P K J00228 IGHG1*01 F CH2 gDNA gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag Z17370 IGHG1*02 F CH2 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- Y14737 IGHG1*03 (F) CH2 cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- JN582178 IGHG1*04 (F) CH2 cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH2 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- _____AB_____ ____________ 15.1 15.3 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29 D T L M I S R T P E V T C V V V D V S J00228 IGHG1*01 F CH2 gDNA gac acc ctc atg atc ... tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc Z17370 IGHG1*02 F CH2 gDNA --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- Y14737 IGHG1*03 (F) CH2 cDNA --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- JN582178 IGHG1*04 (F) CH2 cDNA --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH2 gDNA --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- _______BC___________________ _____________CD_________ 45.1 45.3 45.5 30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6 H E D P E V K F N W Y V D G V E V H J00228 IGHG1*01 F CH2 gDNA cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat ... ... Z17370 IGHG1*02 F CH2 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... Y14737 IGHG1*03 (F) CH2 cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... JN582178 IGHG1*04 (F) CH2 cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... AL122127 IGHG1*05 F CH2 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ____ ___________________________DE_______________ 45.7 84.1 84.3 84.5 84.7 85.6 85.4 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5 N A K T K P R E E Q Y N S J00228 IGHG1*01 F CH2 gDNA ... aat gcc aag aca aag ccg cgg gag gag cag tac aac ... ... ... ... ... ... agc Z17370 IGHG1*02 F CH2 gDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- Y14737 IGHG1*03 (F) CH2 cDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- JN582178 IGHG1*04 (F) CH2 cDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- AL122127 IGHG1*05 F CH2 gDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- ____________ ___EF___ 85.2 96.1 85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99 T Y R V V S V L T V L H Q D W L N G J00228 IGHG1*01 F CH2 gDNA acg tac cgg gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ... ... ctg aat ggc Z17370 IGHG1*02 F CH2 gDNA --- --- --t --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- Y14737 IGHG1*03 (F) CH2 cDNA --- --- --t --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- JN582178 IGHG1*04 (F) CH2 cDNA --- --- --t --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- AL122127 IGHG1*05 F CH2 gDNA --- --- --t --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- _________________________FG_________________________ 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 K E Y K C K V S N K A L P A P I E K J00228 IGHG1*01 F CH2 gDNA aag gag tac aag tgc aag gtc tcc aac aaa gcc ... ... ctc cca gcc ccc atc gag aaa Z17370 IGHG1*02 F CH2 gDNA --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- Y14737 IGHG1*03 (F) CH2 cDNA --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- JN582178 IGHG1*04 (F) CH2 cDNA --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH2 gDNA --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- --- 120 121 122 123 124 125 T I S K A K J00228 IGHG1*01 F CH2 gDNA acc atc tcc aaa gcc aaa Z17370 IGHG1*02 F CH2 gDNA --- --- --- --- --- --- Y14737 IGHG1*03 (F) CH2 cDNA --- --- --- --- --- --- JN582178 IGHG1*04 (F) CH2 cDNA --- --- --- --- --- --- AL122127 IGHG1*05 F CH2 gDNA --- --- --- --- --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12 G Q P R E P Q V Y T L P P S R D J00228 IGHG1*01 F CH3-CHS gDNA ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat Z17370 IGHG1*02 F CH3-CHS gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- E Y14737 IGHG1*03 (F) CH3-CHS cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --g JN582178 IGHG1*04 (F) CH3-CHS cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH3-CHS gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- _____AB_____ ____________ 15.1 15.3 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29 E L T K N Q V S L T C L V K G F Y J00228 IGHG1*01 F CH3-CHS gDNA gag ctg acc ... ... ... aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat Z17370 IGHG1*02 F CH3-CHS gDNA --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- M Y14737 IGHG1*03 (F) CH3-CHS cDNA --- a-- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- JN582178 IGHG1*04 (F) CH3-CHS cDNA --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH3-CHS gDNA --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- _______BC___________________ _____________CD_________ 45.1 45.3 45.5 30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6 P S D I A V E W E S N G Q P E N J00228 IGHG1*01 F CH3-CHS gDNA ccc ... ... agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac ... ... Z17370 IGHG1*02 F CH3-CHS gDNA --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... Y14737 IGHG1*03 (F) CH3-CHS cDNA --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... JN582178 IGHG1*04 (F) CH3-CHS cDNA --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... AL122127 IGHG1*05 F CH3-CHS gDNA --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ____ ___________________________DE_______________ 45.7 84.1 84.3 84.5 84.7 85.6 85.4 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5 N Y K T T P P V L D S D G J00228 IGHG1*01 F CH3-CHS gDNA ... aac tac aag acc acg cct ccc gtg ctg gac tcc gac ... ... ... ... ... ... ggc Z17370 IGHG1*02 F CH3-CHS gDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- Y14737 IGHG1*03 (F) CH3-CHS cDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- JN582178 IGHG1*04 (F) CH3-CHS cDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- AL122127 IGHG1*05 F CH3-CHS gDNA ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- ____________ ___EF___ 85.2 96.1 85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99 S F F L Y S K L T V D K S R W Q Q G J00228 IGHG1*01 F CH3-CHS gDNA tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg ... ... cag cag ggg Z17370 IGHG1*02 F CH3-CHS gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- Y14737 IGHG1*03 (F) CH3-CHS cDNA --- --- --- --- --t --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- JN582178 IGHG1*04 (F) CH3-CHS cDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- AL122127 IGHG1*05 F CH3-CHS gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- _________________________FG_________________________ 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 N V F S C S V M H E A L H N H Y T Q K J00228 IGHG1*01 F CH3-CHS gDNA aac gtc ttc tca tgc tcc gtg atg cat gag gct ... ctg cac aac cac tac acg cag aag Z17370 IGHG1*02 F CH3-CHS gDNA --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- Y14737 IGHG1*03 (F) CH3-CHS cDNA --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- I JN582178 IGHG1*04 (F) CH3-CHS cDNA --- a-- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- AL122127 IGHG1*05 F CH3-CHS gDNA --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --a --- --- __CHS___ 120 121 122 123 124 125 126 127 128 129 130 S L S L S P G K J00228 IGHG1*01 F CH3-CHS gDNA agc ctc tcc ctg tct ccg ... ... ... ggt aaa Z17370 IGHG1*02 F CH3-CHS gDNA --- --- --- --- --- --- ... ... ... --- --- Y14737 IGHG1*03 (F) CH3-CHS cDNA --- --- --- --- --c --- ... ... ... --- --- JN582178 IGHG1*04 (F) CH3-CHS cDNA --- --- --- --- --- --- ... ... ... --- --- AL122127 IGHG1*05 F CH3-CHS gDNA --- --- --- --- --- --- ... ... ... --- ---
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
E L Q L E E S C A E A Q D G E L D G L W
X52847 IGHG1*01 F M1 cDNA gag ctg caa ctg gag gag agc tgt gcg gag gcg cag gac ggg gag ctg gac ggg ctg tgg
AL122127 IGHG1*05 F M1 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40
T T I T I F I T L F L L S V C Y S A T V
X52847 IGHG1*01 F M1 cDNA acg acc atc acc atc ttc atc aca ctc ttc ctg tta agc gtg tgc tac agt gcc acc gtc
AL122127 IGHG1*05 F M1 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
41 42 43 44
T F F K
X52847 IGHG1*01 F M1 cDNA acc ttc ttc aag
AL122127 IGHG1*05 F M1 gDNA --- --- --- ---
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
V K W I F S S V V D L K Q T I I P D Y R
X52847 IGHG1*01 F M2 cDNA gtg aag tgg atc ttc tcc tcg gtg gtg gac ctg aag cag acc atc atc ccc gac tac agg
AL122127 IGHG1*05 F M2 gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
21 22 23 24 25 26 27
N M I G Q G A
X52847 IGHG1*01 F M2 cDNA aac atg atc gga cag ggg gcc
AL122127 IGHG1*05 F M2 gDNA --- --- --- --- --- --- ---
IMGT note:
IMGT Reference:
This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).
Software material and data coming from IMGT server may be used for academic research only,
provided that it is referred to IMGT®, and cited as
"IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org
(founder and director: Marie-Paule Lefranc, Montpellier, France)."
References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209
Full text
Cover;
Ruiz, M. et al.,
Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219
Full text;
Lefranc, M.-P.,
Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207
Full text;
Lefranc, M.-P.,
Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085
Full text;
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056
Full text.
For any other use please contact Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr.
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