Here you are: IMGT Web resources > IMGT Repertoire > Proteins and alleles

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                      A   S   T   K   G   P   S   V   F   P   L   A   P   C   S   R 
  J00230   IGHG2*01   F   CH1 gDNA                   gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg
                                                                                                                    
  AJ250170 IGHG2*02   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      S   T   S               E   S   T   A   A   L   G   C   L   V   K   D   Y   F 
  J00230   IGHG2*01   F   CH1 gDNA   agc acc tcc ... ... ... gag agc aca gcc gcc ctg ggc tgc ctg gtc aag gac tac ttc
                                                                                                                    
  AJ250170 IGHG2*02   F   CH1 gDNA   --- --- --- ... ... ... --- --- --- --g --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH1 gDNA   --- --- --- ... ... ... --- --- --- --g --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH1 gDNA   --- --- --- ... ... ... --- --- --- --g --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH1 gDNA   --- --- --- ... ... ... --- --- --- --g --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH1 gDNA   --- --- --- ... ... ... --- --- --- --g --- --- --- --- --- --- --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      P           E   P   V   T   V   S   W   N   S   G   A   L   T   S             
  J00230   IGHG2*01   F   CH1 gDNA   ccc ... ... gaa ccg gtg acg gtg tcg tgg aac tca ggc gct ctg acc agc ... ... ...
                                                                                                                    
  AJ250170 IGHG2*02   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                    
  AF449616 IGHG2*03   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                    
  AF449617 IGHG2*04   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                    
  AF449618 IGHG2*05   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                    
  AL928742 IGHG2*06   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          G   V   H   T   F   P   A   V   L   Q   S   S                           G 
  J00230   IGHG2*01   F   CH1 gDNA   ... ggc gtg cac acc ttc cca gct gtc cta cag tcc tca ... ... ... ... ... ... gga
                                                                                                                    
  AJ250170 IGHG2*02   F   CH1 gDNA   ... --- --- --- --- --- --g --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH1 gDNA   ... --- --- --- --- --- --g --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      L   Y   S   L   S   S   V   V   T   V   P   S   S   N   F               G   T 
  J00230   IGHG2*01   F   CH1 gDNA   ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc aac ttc ... ... ... ggc acc
                                                                              T                                     
  AJ250170 IGHG2*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- a-- --- --- --- --- ... ... ... --- ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
                                                                                          S   L                     
  AF449617 IGHG2*04   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- -g- --g ... ... ... --- ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      Q   T   Y   T   C   N   V   D   H   K   P           S   N   T   K   V   D   K 
  J00230   IGHG2*01   F   CH1 gDNA   cag acc tac acc tgc aac gta gat cac aag ccc ... ... agc aac acc aag gtg gac aag
                                                                                                                    
  AJ250170 IGHG2*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                             
                                     
                                     120 121 
                                      T   V  
  J00230   IGHG2*01   F   CH1 gDNA   aca gtt 
                                             
  AJ250170 IGHG2*02   F   CH1 gDNA   --- --- 
                                             
  AF449616 IGHG2*03   F   CH1 gDNA   --- --- 
                                             
  AF449617 IGHG2*04   F   CH1 gDNA   --- --- 
                                             
  AF449618 IGHG2*05   F   CH1 gDNA   --- --- 
                                             
  AL928742 IGHG2*06   F   CH1 gDNA   --- --- 
                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12 
                                    E   R   K   C   C   V   E   C   P   P   C   P  
  J00230   IGHG2*01   F   H gDNA   gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca 
                                                                                   
  Z49802   IGHG2*01   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                   
  AJ250170 IGHG2*02   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                   
  Z49801   IGHG2*02   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                   
  AF449616 IGHG2*03   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                   
  AF449617 IGHG2*04   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                   
  AF449618 IGHG2*05   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                   
  AL928742 IGHG2*06   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                                                     
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                              A   P       P   V   A   G   P   S   V   F   L   F   P   P   K   P   K 
  J00230   IGHG2*01   F   CH2 gDNA (1)       gca cca ... cct gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag
                                                                                                                    
  Z49802   IGHG2*01   F   CH2 gDNA (2)       --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AJ250170 IGHG2*02   F   CH2 gDNA           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  Z49801   IGHG2*02   F   CH2 gDNA           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH2 gDNA           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH2 gDNA           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH2 gDNA           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH2 gDNA           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   T   L   M   I       S   R   T   P   E   V   T   C   V   V   V   D   V   S 
  J00230   IGHG2*01   F   CH2 gDNA   gac acc ctc atg atc ... tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc
                                                                                                                    
  Z49802   IGHG2*01   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AJ250170 IGHG2*02   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  Z49801   IGHG2*02   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      H   E   D   P   E   V   Q   F   N   W   Y   V   D   G   V   E   V   H         
  J00230   IGHG2*01   F   CH2 gDNA   cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat ... ...
                                                                                                                    
  Z49802   IGHG2*01   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                              M                     
  AJ250170 IGHG2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- a-- --- --- --- ... ...
                                                                                              M                     
  Z49801   IGHG2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- a-- --- --- --- ... ...
                                                                                                                    
  AF449616 IGHG2*03   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                    
  AF449617 IGHG2*04   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                    
  AF449618 IGHG2*05   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                    
  AL928742 IGHG2*06   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          N   A   K   T   K   P   R   E   E   Q   F   N                           S 
  J00230   IGHG2*01   F   CH2 gDNA   ... aat gcc aag aca aag cca cgg gag gag cag ttc aac ... ... ... ... ... ... agc
                                                                                                                    
  Z49802   IGHG2*01   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AJ250170 IGHG2*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  Z49801   IGHG2*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      T   F   R   V   V   S   V   L   T   V   V   H   Q   D   W           L   N   G 
  J00230   IGHG2*01   F   CH2 gDNA   acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ... ... ctg aac ggc
                                                                                                                    
  Z49802   IGHG2*01   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  AJ250170 IGHG2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --c --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  Z49801   IGHG2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --c --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --c --- --- --- --- --- ... ... --- --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   E   Y   K   C   K   V   S   N   K   G           L   P   A   P   I   E   K 
  J00230   IGHG2*01   F   CH2 gDNA   aag gag tac aag tgc aag gtc tcc aac aaa ggc ... ... ctc cca gcc ccc atc gag aaa
                                                                                                                    
  Z49802   IGHG2*01   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AJ250170 IGHG2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  Z49801   IGHG2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AF449616 IGHG2*03   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AF449617 IGHG2*04   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AF449618 IGHG2*05   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG2*06   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                             
                                     
                                     120 121 122 123 124 125 
                                      T   I   S   K   T   K  
  J00230   IGHG2*01   F   CH2 gDNA   acc atc tcc aaa acc aaa 
                                                             
  Z49802   IGHG2*01   F   CH2 gDNA   --- --- --- --- --- --- 
                                                             
  AJ250170 IGHG2*02   F   CH2 gDNA   --- --- --- --- --- --- 
                                                             
  Z49801   IGHG2*02   F   CH2 gDNA   --- --- --- --- --- --- 
                                                             
  AF449616 IGHG2*03   F   CH2 gDNA   --- --- --- --- --- --- 
                                                             
  AF449617 IGHG2*04   F   CH2 gDNA   --- --- --- --- --- --- 
                                                             
  AF449618 IGHG2*05   F   CH2 gDNA   --- --- --- --- --- --- 
                                                             
  AL928742 IGHG2*06   F   CH2 gDNA   --- --- --- --- --- --- 
                                                                                                                         
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          G   Q   P   R   E   P   Q   V   Y   T   L   P   P   S   R   E 
  J00230   IGHG2*01   F   CH3-CHS gDNA                   ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag
                                                                                                                        
  Z49802   IGHG2*01   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AJ250170 IGHG2*02   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  Z49801   IGHG2*02   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AF449616 IGHG2*03   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AF449617 IGHG2*04   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AF449618 IGHG2*05   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AL928742 IGHG2*06   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          E   M   T               K   N   Q   V   S   L   T   C   L   V   K   G   F   Y 
  J00230   IGHG2*01   F   CH3-CHS gDNA   gag atg acc ... ... ... aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac
                                                                                                                        
  Z49802   IGHG2*01   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AJ250170 IGHG2*02   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  Z49801   IGHG2*02   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AF449616 IGHG2*03   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AF449617 IGHG2*04   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AF449618 IGHG2*05   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AL928742 IGHG2*06   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           S   D   I   A   V   E   W   E   S   N   G   Q   P   E   N         
  J00230   IGHG2*01   F   CH3-CHS gDNA   ccc ... ... agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac ... ...
                                                                                                                        
  Z49802   IGHG2*01   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                        
  AJ250170 IGHG2*02   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                        
  Z49801   IGHG2*02   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                        
  AF449616 IGHG2*03   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                        
  AF449617 IGHG2*04   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                        
  AF449618 IGHG2*05   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                  S                                                     
  AL928742 IGHG2*06   F   CH3-CHS gDNA   --- ... ... --- --- --- t-- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              N   Y   K   T   T   P   P   M   L   D   S   D                           G 
  J00230   IGHG2*01   F   CH3-CHS gDNA   ... aac tac aag acc aca cct ccc atg ctg gac tcc gac ... ... ... ... ... ... ggc
                                                                                                                        
  Z49802   IGHG2*01   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  AJ250170 IGHG2*02   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  Z49801   IGHG2*02   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  AF449616 IGHG2*03   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  AF449617 IGHG2*04   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  AF449618 IGHG2*05   F   CH3-CHS gDNA   ... --- --- --- --- --g --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  AL928742 IGHG2*06   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          S   F   F   L   Y   S   K   L   T   V   D   K   S   R   W           Q   Q   G 
  J00230   IGHG2*01   F   CH3-CHS gDNA   tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg ... ... cag cag ggg
                                                                                                                        
  Z49802   IGHG2*01   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                        
  AJ250170 IGHG2*02   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                        
  Z49801   IGHG2*02   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                        
  AF449616 IGHG2*03   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                        
  AF449617 IGHG2*04   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                        
  AF449618 IGHG2*05   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                        
  AL928742 IGHG2*06   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          N   V   F   S   C   S   V   M   H   E   A       L   H   N   H   Y   T   Q   K 
  J00230   IGHG2*01   F   CH3-CHS gDNA   aac gtc ttc tca tgc tcc gtg atg cat gag gct ... ctg cac aac cac tac acg cag aag
                                                                                                                        
  Z49802   IGHG2*01   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                        
  AJ250170 IGHG2*02   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --a --- ---
                                                                                                                        
  Z49801   IGHG2*02   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --a --- ---
                                                                                                                        
  AF449616 IGHG2*03   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                        
  AF449617 IGHG2*04   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                        
  AF449618 IGHG2*05   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                        
  AL928742 IGHG2*06   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --a --- ---


                                                                             __CHS___
                                         
                                         120 121 122 123 124 125 126 127 128 129 130 
                                          S   L   S   L   S   P               G   K  
  J00230   IGHG2*01   F   CH3-CHS gDNA   agc ctc tcc ctg tct ccg ... ... ... ggt aaa 
                                                                                     
  Z49802   IGHG2*01   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  AJ250170 IGHG2*02   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  Z49801   IGHG2*02   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  AF449616 IGHG2*03   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  AF449617 IGHG2*04   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  AF449618 IGHG2*05   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  AL928742 IGHG2*06   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                    
                                    
                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                     E   L   Q   L   E   E   S   C   A   E   A   Q   D   G   E   L   D   G   L   W 
  AB006775 IGHG2*01   F   M1 gDNA   gag ctg caa ctg gag gag agc tgt gcg gag gcg cag gac ggg gag ctg gac ggg ctg tgg
                                                                                                                   
  AL928742 IGHG2*06   F   M1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    
                                    
                                     21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                     T   T   I   T   I   F   I   T   L   F   L   L   S   V   C   Y   S   A   T   I 
  AB006775 IGHG2*01   F   M1 gDNA   acg acc atc acc atc ttc atc aca ctc ttc ctg cta agc gtg tgc tac agt gcc acc atc
                                                                                                                   
  AL928742 IGHG2*06   F   M1 gDNA   --c --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    
                                    
                                     41  42  43  44 
                                     T   F   F   K  
  AB006775 IGHG2*01   F   M1 gDNA   acc ttc ttc aag 
                                                    
  AL928742 IGHG2*06   F   M1 gDNA   --- --- --- --- 
                                    
                                    
                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                     V   K   W   I   F   S   S   V   V   D   L   K   Q   T   I   V   P   D   Y   R 
  AB006776 IGHG2*01   F   M2 gDNA   gtg aag tgg atc ttc tcc tca gtg gtg gac ctg aag cag acc atc gtc ccc gac tac agg
                                                                                                                   
  AL928742 IGHG2*06   F   M2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    
                                    
                                     21  22  23  24  25  26  27 
                                     N   M   I   R   Q   G   A  
  AB006776 IGHG2*01   F   M2 gDNA   aac atg atc agg cag ggg gcc 
                                                                
  AL928742 IGHG2*06   F   M2 gDNA   --- --- --- --- --- --- --- 
 
  
  
IMGT notes:

(1) The gap at position 3 of the CH2 exon allows to keep the same codon numbering as in the other human IGHG genes.

(2) Z49802 previously described as a IGHG2*03 allele due to a289>g, g291>a, T97>A in CH3 is now considered as a IGHG2*01 allele, following the EMBL update of 20 september 1999 (a289, g291, T97).



This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
20/01/1999
Last updated:
27/05/2016
Authors:
Saida Saljoqi, Christèle Martinez-Jean and Nathalie Bosc