Here you are: IMGT Web resources > IMGT Repertoire > Proteins and alleles

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                      A   S   T   K   G   P   S   V   F   P   L   A   P   C   S   R 
  K01316   IGHG4*01   F   CH1 gDNA                   gct tcc acc aag ggc cca tcc gtc ttc ccc ctg gcg ccc tgc tcc agg
                                                                                                                    
  AL928742 IGHG4*04   F   CH1 gDNA                   --- --- --- --- --- --- --g --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      S   T   S               E   S   T   A   A   L   G   C   L   V   K   D   Y   F 
  K01316   IGHG4*01   F   CH1 gDNA   agc acc tcc ... ... ... gag agc aca gcc gcc ctg ggc tgc ctg gtc aag gac tac ttc
                                                                                                                    
  AL928742 IGHG4*04   F   CH1 gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      P           E   P   V   T   V   S   W   N   S   G   A   L   T   S             
  K01316   IGHG4*01   F   CH1 gDNA   ccc ... ... gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ... ... ...
                                                                                                                    
  AL928742 IGHG4*04   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          G   V   H   T   F   P   A   V   L   Q   S   S                           G 
  K01316   IGHG4*01   F   CH1 gDNA   ... ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca ... ... ... ... ... ... gga
                                                                                                                    
  AL928742 IGHG4*04   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      L   Y   S   L   S   S   V   V   T   V   P   S   S   S   L               G   T 
  K01316   IGHG4*01   F   CH1 gDNA   ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ... ... ... ggc acg
                                                                                                                    
  AL928742 IGHG4*04   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   T   Y   T   C   N   V   D   H   K   P           S   N   T   K   V   D   K 
  K01316   IGHG4*01   F   CH1 gDNA   aag acc tac acc tgc aac gta gat cac aag ccc ... ... agc aac acc aag gtg gac aag
                                                                                                                    
  AL928742 IGHG4*04   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                             
                                     
                                     120 121 
                                      R   V  
  K01316   IGHG4*01   F   CH1 gDNA   aga gtt 
                                             
  AL928742 IGHG4*04   F   CH1 gDNA   --- --- 
                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12 
                                    E   S   K   Y   G   P   P   C   P   S   C   P  
  K01316   IGHG4*01   F   H gDNA   gag tcc aaa tat ggt ccc cca tgc cca tca tgc cca 
                                                                                   
  AJ001563 IGHG4*02   F   H gDNA   --- --- --- --- --- --- --g --- --- --- --- --- 
                                                                                   
  AL928742 IGHG4*04   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                                                     
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                              A   P   E   F   L   G   G   P   S   V   F   L   F   P   P   K   P   K 
  K01316   IGHG4*01   F   CH2 gDNA           gca cct gag ttc ctg ggg gga cca tca gtc ttc ctg ttc ccc cca aaa ccc aag
                                                                                                                    
  AJ001563 IGHG4*02   F   CH2 gDNA           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AJ001564 IGHG4*03   F   CH2 gDNA           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG4*04   F   CH2 gDNA           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   T   L   M   I       S   R   T   P   E   V   T   C   V   V   V   D   V   S 
  K01316   IGHG4*01   F   CH2 gDNA   gac act ctc atg atc ... tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc
                                                                                                                    
  AJ001563 IGHG4*02   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AJ001564 IGHG4*03   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG4*04   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      Q   E   D   P   E   V   Q   F   N   W   Y   V   D   G   V   E   V   H         
  K01316   IGHG4*01   F   CH2 gDNA   cag gaa gac ccc gag gtc cag ttc aac tgg tac gtg gat ggc gtg gag gtg cat ... ...
                                                                                                                    
  AJ001563 IGHG4*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                    
  AJ001564 IGHG4*03   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                    
  AL928742 IGHG4*04   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          N   A   K   T   K   P   R   E   E   Q   F   N                           S 
  K01316   IGHG4*01   F   CH2 gDNA   ... aat gcc aag aca aag ccg cgg gag gag cag ttc aac ... ... ... ... ... ... agc
                                                                                                                    
  AJ001563 IGHG4*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AJ001564 IGHG4*03   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  AL928742 IGHG4*04   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      T   Y   R   V   V   S   V   L   T   V   L   H   Q   D   W           L   N   G 
  K01316   IGHG4*01   F   CH2 gDNA   acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ... ... ctg aac ggc
                                                                              V                                     
  AJ001563 IGHG4*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- g-- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  AJ001564 IGHG4*03   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  AL928742 IGHG4*04   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   E   Y   K   C   K   V   S   N   K   G           L   P   S   S   I   E   K 
  K01316   IGHG4*01   F   CH2 gDNA   aag gag tac aag tgc aag gtc tcc aac aaa ggc ... ... ctc ccg tcc tcc atc gag aaa
                                                                                                                    
  AJ001563 IGHG4*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AJ001564 IGHG4*03   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  AL928742 IGHG4*04   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                             
                                     
                                     120 121 122 123 124 125 
                                      T   I   S   K   A   K  
  K01316   IGHG4*01   F   CH2 gDNA   acc atc tcc aaa gcc aaa 
                                                             
  AJ001563 IGHG4*02   F   CH2 gDNA   --- --- --- --- --- --- 
                                                             
  AJ001564 IGHG4*03   F   CH2 gDNA   --- --- --- --- --- --- 
                                                             
  AL928742 IGHG4*04   F   CH2 gDNA   --- --- --- --- --- --- 
                                                                                                                         
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          G   Q   P   R   E   P   Q   V   Y   T   L   P   P   S   Q   E 
  K01316   IGHG4*01   F   CH3-CHS gDNA                   ggg cag ccc cga gag cca cag gtg tac acc ctg ccc cca tcc cag gag
                                                                                                                        
  AJ001563 IGHG4*02   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AJ001564 IGHG4*03   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AL928742 IGHG4*04   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          E   M   T               K   N   Q   V   S   L   T   C   L   V   K   G   F   Y 
  K01316   IGHG4*01   F   CH3-CHS gDNA   gag atg acc ... ... ... aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac
                                                                                                                        
  AJ001563 IGHG4*02   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AJ001564 IGHG4*03   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  AL928742 IGHG4*04   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           S   D   I   A   V   E   W   E   S   N   G   Q   P   E   N         
  K01316   IGHG4*01   F   CH3-CHS gDNA   ccc ... ... agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac ... ...
                                                                                                                        
  AJ001563 IGHG4*02   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                        
  AJ001564 IGHG4*03   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                        
  AL928742 IGHG4*04   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              N   Y   K   T   T   P   P   V   L   D   S   D                           G 
  K01316   IGHG4*01   F   CH3-CHS gDNA   ... aac tac aag acc acg cct ccc gtg ctg gac tcc gac ... ... ... ... ... ... ggc
                                                                                                                        
  AJ001563 IGHG4*02   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  AJ001564 IGHG4*03   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  AL928742 IGHG4*04   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          S   F   F   L   Y   S   R   L   T   V   D   K   S   R   W           Q   E   G 
  K01316   IGHG4*01   F   CH3-CHS gDNA   tcc ttc ttc ctc tac agc agg cta acc gtg gac aag agc agg tgg ... ... cag gag ggg
                                                                                                                        
  AJ001563 IGHG4*02   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                  K                                                     
  AJ001564 IGHG4*03   F   CH3-CHS gDNA   --- --- --- --- --- --- -a- --c --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                        
  AL928742 IGHG4*04   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --c --- --- --- --- --- --- --- ... ... --- --- ---


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          N   V   F   S   C   S   V   M   H   E   A       L   H   N   H   Y   T   Q   K 
  K01316   IGHG4*01   F   CH3-CHS gDNA   aat gtc ttc tca tgc tcc gtg atg cat gag gct ... ctg cac aac cac tac aca cag aag
                                                                                                                        
  AJ001563 IGHG4*02   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --g --- ---
                                                                                                                        
  AJ001564 IGHG4*03   F   CH3-CHS gDNA   --c --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --g --- ---
                                                                                                                        
  AL928742 IGHG4*04   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                             __CHS___
                                         
                                         120 121 122 123 124 125 126 127 128 129 130 
                                          S   L   S   L   S   L               G   K  
  K01316   IGHG4*01   F   CH3-CHS gDNA   agc ctc tcc ctg tct ctg ... ... ... ggt aaa 
                                                                                     
  AJ001563 IGHG4*02   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  AJ001564 IGHG4*03   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  AL928742 IGHG4*04   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- 

                                    
                                    
                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                     E   L   Q   L   E   E   S   C   A   E   A   Q   D   G   E   L   D   G   L   W 
  AL928742 IGHG4*04   F   M1 gDNA   gag ctg caa ctg gag gag agc tgt gcg gag gcg cag gac ggg gag ctg gac ggg ctg tgg


                                    
                                    
                                     21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                     T   T   I   T   I   F   I   T   L   F   L   L   S   V   C   Y   S   A   T   V 
  AL928742 IGHG4*04   F   M1 gDNA   acg acc atc acc atc ttc atc aca ctc ttc ctg cta agc gtg tgc tac agt gcc acc gtc


                                    
                                    
                                     41  42  43  44 
                                     T   F   F   K  
  AL928742 IGHG4*04   F   M1 gDNA   acc ttc ttc aag 
                                   
                                    
                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                     V   K   W   I   F   S   S   V   V   D   L   K   Q   T   I   V   P   D   Y   R 
  AL928742 IGHG4*04   F   M2 gDNA   gtg aag tgg atc ttc tcc tca gtg gtg gac ctg aag cag acc atc gtc ccc gac tac agg


                                    
                                    
                                     21  22  23  24  25  26  27 
                                     N   M   I   R   Q   G   A  
  AL928742 IGHG4*04   F   M2 gDNA   aac atg ata agg cag ggg gcc 
  

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
20/01/1999
Last updated:
27/05/2016
Authors:
Saida Saljoqi, Christèle Martinez-Jean and Nathalie Bosc