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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                                                         
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          A   S   T   K   A   P   D   V   F   P   I   T   S   A   C   Q 
  Macfas_2_Chr7 IGHD*01 ORF CH1 gDNA                     gca tcc acc aag gct ccg gat gtg ttc ccc atc aca tca gca tgc caa


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          L   P   K   D           N   S   P   V   V   L   A   C   L   I   T   G   Y   N 
  Macfas_2_Chr7 IGHD*01 ORF CH1 gDNA     ctc cca aag gat ... ... aac agc cct gtg gtc ctg gca tgc ttg ata act ggg tac aac


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           K   S   V   T   V   T   W   H   L   G   T   Q   I   Q             
  Macfas_2_Chr7 IGHD*01 ORF CH1 gDNA     cca ... ... aag tcc gtg act gtc acc tgg cac ctg ggg aca cag atc cag ... ... ...


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              N   Q   T   M   F   P   E   T   E   R   E   G                             
  Macfas_2_Chr7 IGHD*01 ORF CH1 gDNA     ... aac cag act atg ttc cct gag aca gag aga gag ggc ... ... ... ... ... ... ...


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          S   Y   T   T   S   S   Q   L   A   P   T   S   P   L   S   Q       Q   H   Q 
  Macfas_2_Chr7 IGHD*01 ORF CH1 gDNA     agc tac acg aca agc agc cag ctc gcc ccc acc tca ccc ctc tcc caa ... cag cac caa


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          G   E   Y   K   C   T   V   K   H   T   P           S   N   T   N   N   E   K 
  Macfas_2_Chr7 IGHD*01 ORF CH1 gDNA     ggc gag tac aaa tgc acc gtg aag cac acc ccc ... ... agc aat aca aac aat gag aag


                                                             
                                         
                                         120 121 122 123 124 
                                          T   F   R   W   P  
  Macfas_2_Chr7 IGHD*01 ORF CH1 gDNA     acc ttc cgc tgg cca 



                                           
                                           
                                            1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                            E   S   P   K   V   Q   Y   P   S   V   P   T   V   Q   P   Q   A   E   G   G 
  Macfas_2_Chr7 IGHD*01 ORF H1+H2 gDNA     gag tct cca aag gta cag tac ccc tca gtg ccc act gta cag ccc caa gca gag ggc ggc


                                           
                                           
                                            21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                            L   S   K   A   T   R   P   P   A   T   N   R   N   T   E   K   K   R   K   G 
  Macfas_2_Chr7 IGHD*01 ORF H1+H2 gDNA     ctc tcc aag gca acc aga ccc cca gcc acc aac agg aac aca gag aag aag aga aaa gga


                                           
                                           
                                            41  42  43  44  45  46  47  48  49  50  51  52  53  54  55 
                                            G   R   G   G   E   R   T   T   R   G   R   D   K   D   P  
  Macfas_2_Chr7 IGHD*01 ORF H1+H2 gDNA     gga cga gga gga gaa aga aca aca aga ggg aga gac aaa gac ccc a



                                                                                                                         
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                              E   C   P   S   H   T   Q   P   L   G   V   Y   L   L   P   P   A   L   Q 
  Macfas_2_Chr7 IGHD*01 ORF CH2 gDNA         gag tgt cca agc cac acc cag cct ctc ggc gtc tac ctg ctg ccc ccg gcc ctg cag


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          D   L   W   F           Q   D   K   A   I   F   T   C   F   V   V   G   S   D 
  Macfas_2_Chr7 IGHD*01 ORF CH2 gDNA     gac ctg tgg ttc ... ... caa gac aaa gcc atc ttc acc tgc ttc gtg gtg ggc agt gac


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          L           Q   D   A   H   L   S   W   E   V   A   G   K   D   P   K   G     
  Macfas_2_Chr7 IGHD*01 ORF CH2 gDNA     ctg ... ... cag gat gcc cac ctg tcc tgg gag gtg gcc ggg aag gac ccc aaa ggg ...


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              G   M   E   K   G   P   L   E   Q   H   S   N                           G 
  Macfas_2_Chr7 IGHD*01 ORF CH2 gDNA     ... ggc atg gag aag ggg cca ctg gag cag cac agc aac ... ... ... ... ... ... ggc


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          S   Q   S   Q   H   S   R   L   A   L   P   R   S   L   W           N   A   G 
  Macfas_2_Chr7 IGHD*01 ORF CH2 gDNA     tcc cag agc cag cac agc cgc ctg gcc cta ccc agg tcc ttg tgg ... ... aat gcg ggg


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          T   S   V   T   C   T   L   N   H   S   S           L   P   S   Q   K   L   M 
  Macfas_2_Chr7 IGHD*01 ORF CH2 gDNA     acc tcc gtc acc tgc aca ctg aac cat tcc agc ... ... ctc cca tcc cag aag ctg atg


                                                             
                                         
                                         120 121 122 123 124 
                                          A   L   R   E   P  
  Macfas_2_Chr7 IGHD*01 ORF CH2 gDNA     gcg ctg aga gaa ccc 



                                                                                                                         
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                              A   A   Q   A   P   V   R   L   S   L   N   L   L   A   S 
  Macfas_2_Chr7 IGHD*01 ORF CH3 gDNA                         gct gcc cag gca ccc gtc agg ctt tcc ctg aac ctg ttg gcc tcg


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          S   D   P   P           E   A   A   S   W   L   L   C   E   V   S   D   F   S 
  Macfas_2_Chr7 IGHD*01 ORF CH3 gDNA     tct gac cct ccg ... ... gaa gca gcc tca tgg ctc ctg tgt gag gtg tct gac ttc tcg


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           P   N   I   L   L   M   W   L   E   D   Q   R   E   V   N   T   S 
  Macfas_2_Chr7 IGHD*01 ORF CH3 gDNA     ccc ... ... ccc aac atc ctc ctg atg tgg ctg gag gac cag cgc gag gtg aac act tct


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              W   F   A   T   T   H   P   T   P   Q   P   G   S                       T 
  Macfas_2_Chr7 IGHD*01 ORF CH3 gDNA     ... tgg ttt gcc acc acg cac ccc act cca cag ccc ggg agc ... ... ... ... ... acc


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          M   F   W   A   W   S   V   L   R   V   P   G   P   T   S           P   Q   P 
  Macfas_2_Chr7 IGHD*01 ORF CH3 gDNA     atg ttc tgg gcc tgg agt gtg ctg cgt gtc cca ggc ccg acc agc ... ... cct cag cca


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          A   T   Y   T   C   V   V   S   H   E   D   S   R   T   L   L   N   A   S   R 
  Macfas_2_Chr7 IGHD*01 ORF CH3 gDNA     gcc acc tac acg tgt gtg gtc agc cac gag gac tcc agg act ctg ctc aac gcc agc cgg


                                                                 
                                         
                                         120 121 122 123 124 
                                          S   L   D   V   S  
  Macfas_2_Chr7 IGHD*01 ORF CH3 gDNA     agc ctg gat gtc agc t

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
17/01/2017
Last updated:
18/01/2017
Authors:
Perrine Pégorier