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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                                                   
                                   
                                   1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                    X   S   T   K   G   P   S   V   F   P   L   A   S   S   S   R 
  CS101556 IGHG4*01 F CH1 gDNA                     ncc tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg tcc tcc tcc agg
                                                                                                                  
  JQ868731 IGHG4*02 F CH1 gDNA                                             --- --- --- --- --- --- --- --- --- ---


                                               _____AB_____                                            ____________
                                               15.1    15.3                                                        
                                    13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                    S   T   S               E   S   T   A   A   L   G   C   L   V   K   D   Y   F 
  CS101556 IGHG4*01 F CH1 gDNA     agc acc tcc ... ... ... gag agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc
                                                                                                                  
  JQ868731 IGHG4*02 F CH1 gDNA     --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   _______BC___________________                            _____________CD_________
                                                                                           45.1    45.3    45.5    
                                    30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                    P           E   P   V   T   V   S   W   N   S   G   A   L   T   S             
  CS101556 IGHG4*01 F CH1 gDNA     ccc ... ... gaa ccc gtg act gtg tcg tgg aac tca ggc gcc ctg acc agc ... ... ...
                                                                                                                  
  JQ868731 IGHG4*02 F CH1 gDNA     --- ... ... --- --- --- --c --- --- --- --- --- --- --- --- --- --- ... ... ...


                                   ____                                ___________________________DE_______________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                        77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                        G   V   H   T   F   P   A   V   L   Q   S   S                           G 
  CS101556 IGHG4*01 F CH1 gDNA     ... ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca ... ... ... ... ... ... ggg
                                                                                                                  
  JQ868731 IGHG4*02 F CH1 gDNA     ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                   ____________                                                ___EF___            
                                       85.2                                                    96.1                
                                   85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                    L   Y   S   L   S   S   V   V   T   V   P   S   S   S   L               G   T 
  CS101556 IGHG4*01 F CH1 gDNA     ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ... ... ... ggc acc
                                                            M                                                     
  JQ868731 IGHG4*02 F CH1 gDNA     --- --- --- --- --- --- a-- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                                       _________________________FG_________________________        
                                   
                                   100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                    Q   T   Y   V   C   N   V   V   H   E   P           S   N   T   K   V   D   K 
  CS101556 IGHG4*01 F CH1 gDNA     cag acc tac gtc tgc aac gtc gtt cat gag ccc ... ... agc aac acc aag gtg gac aag
                                                                                                                  
  JQ868731 IGHG4*02 F CH1 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                           
                                   
                                   120 121 
                                    R   V  
  CS101556 IGHG4*01 F CH1 gDNA     aga gtt 
                                           
  JQ868731 IGHG4*02 F CH1 gDNA     --- --- 



                                 
                                 
                                  1   2   3   4   5   6   7   8   9   10 
                                  E   F   T   P   P   C   P   P   C   P  
  CS101556 IGHG4*01 F H gDNA     gag ttc aca ccc cca tgc cca cca tgc cca 
                                                                         
  JQ868731 IGHG4*02 F H gDNA     --- --- --- --- --- --- --- --- --- --- 



                                                                                                                   
                                   
                                   1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                            A   P   E   L   L   G   G   P   S   V   F   L   F   P   P   K   P   K 
  CS101556 IGHG4*01 F CH2 gDNA             gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag
                                                                                                                  
  JQ868731 IGHG4*02 F CH2 gDNA             --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                               _____AB_____                                            ____________
                                               15.1    15.3                                                        
                                    13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                    D   T   L   M   I       S   R   T   P   E   V   T   C   V   V   V   D   V   S 
  CS101556 IGHG4*01 F CH2 gDNA     gac acc ctc atg atc ... tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc
                                                                                                                  
  JQ868731 IGHG4*02 F CH2 gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --g --- --- --- --- --- --- ---


                                   _______BC___________________                            _____________CD_________
                                                                                           45.1    45.3    45.5    
                                    30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                    Q   E   D   P   E   V   Q   F   N   W   Y   V   D   G   V   E   V   H         
  CS101556 IGHG4*01 F CH2 gDNA     cag gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat ... ...
                                                                                            A                     
  JQ868731 IGHG4*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- -c- --- --- --c ... ...


                                   ____                                ___________________________DE_______________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                        77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                        H   A   Q   T   K   P   R   E   R   Q   F   N                           S 
  CS101556 IGHG4*01 F CH2 gDNA     ... cat gcc cag acg aag cca cgg gag agg cag ttc aac ... ... ... ... ... ... agc
                                        N                                                                         
  JQ868731 IGHG4*02 F CH2 gDNA     ... a-- --- --- --a --- --g --- --- --- --- --- --- ... ... ... ... ... ... ---


                                   ____________                                                ___EF___            
                                       85.2                                                    96.1                
                                   85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                    T   Y   R   V   V   S   V   L   T   V   T   H   Q   D   W           L   N   G 
  CS101556 IGHG4*01 F CH2 gDNA     acg tac cgc gtg gtc agc gtc ctc acc gtc aca cac cag gac tgg ... ... ctg aac ggc
                                                                                                                  
  JQ868731 IGHG4*02 F CH2 gDNA     --a --t --t --- --- --- --- --- --- --- --g --- --- --- --- ... ... --- --- ---


                                                       _________________________FG_________________________        
                                   
                                   100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                    K   E   Y   T   C   K   V   S   N   K   G           L   P   A   P   I   E   K 
  CS101556 IGHG4*01 F CH2 gDNA     aag gag tac acg tgc aag gtc tcc aac aaa ggc ... ... ctc ccg gcc ccc atc gag aaa
                                                                                                                  
  JQ868731 IGHG4*02 F CH2 gDNA     --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                           
                                   
                                   120 121 122 123 124 125 
                                    T   I   S   K   A   K  
  CS101556 IGHG4*01 F CH2 gDNA     acc atc tcc aaa gcc aaa 
                                                           
  JQ868731 IGHG4*02 F CH2 gDNA     --- --- --- --- --- --- 



                                                                                                                       
                                       
                                       1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                        G   Q   P   R   E   P   Q   V   Y   I   L   P   P   P   Q   E 
  CS101556 IGHG4*01 F CH3-CHS gDNA                     ggg cag ccc cga gag ccg cag gtg tac atc ctg ccc ccg ccc cag gag
                                                                                                                      
  JQ868731 IGHG4*02 F CH3-CHS gDNA                     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                   _____AB_____                                            ____________
                                                   15.1    15.3                                                        
                                        13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                        E   L   T               K   N   Q   V   S   L   T   C   L   V   T   G   F   Y 
  CS101556 IGHG4*01 F CH3-CHS gDNA     gag ctg acc ... ... ... aag aac cag gtc agc ctg acc tgc ctg gtc aca ggc ttc tac
                                                                                                                      
  JQ868731 IGHG4*02 F CH3-CHS gDNA     --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                       _______BC___________________                            _____________CD_________
                                                                                               45.1    45.3    45.5    
                                        30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                        P           S   D   I   A   V   E   W   E   S   N   G   Q   P   E   N         
  CS101556 IGHG4*01 F CH3-CHS gDNA     ccc ... ... agc gac atc gcc gtg gag tgg gag agc aac ggg cag ccg gag aac ... ...
                                                                    M                   S                             
  JQ868731 IGHG4*02 F CH3-CHS gDNA     --- ... ... --- --- --- --- a-- --- --- --- --- -g- --- --- --- --- --- ... ...


                                       ____                                ___________________________DE_______________
                                       45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                            77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                            T   Y   K   T   T   P   P   V   L   D   S   D                           G 
  CS101556 IGHG4*01 F CH3-CHS gDNA     ... acc tac aag acc acc ccg ccc gtg ctg gac tcc gac ... ... ... ... ... ... ggc
                                                                                                                      
  JQ868731 IGHG4*02 F CH3-CHS gDNA     ... --- --- --- --- --g --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                       ____________                                                ___EF___            
                                           85.2                                                    96.1                
                                       85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                        S   Y   F   L   Y   S   K   L   I   V   D   K   S   R   W           Q   Q   G 
  CS101556 IGHG4*01 F CH3-CHS gDNA     tcc tac ttc ctc tac agc aag ctc atc gtg gac aag agc agg tgg ... ... cag cag ggg
                                                                        T       N                                     
  JQ868731 IGHG4*02 F CH3-CHS gDNA     --- --- --- --- --- --- --- --- -c- --- a-- --- --- --- --- ... ... --- --- ---


                                                           _________________________FG_________________________        
                                       
                                       100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                        N   T   F   S   C   S   V   M   H   E   A       L   H   N   H   Y   T   Q   K 
  CS101556 IGHG4*01 F CH3-CHS gDNA     aac acc ttc tca tgc tcc gtg atg cat gag gct ... ctg cac aac cac tac acc cag aag
                                                                                   
  JQ868731 IGHG4*02 F CH3-CHS gDNA     --- --- --- --- --- --- --- --- --- --- --- 


                                                                           __CHS___
                                       
                                       120 121 122 123 124 125 126 127 128 129 130 
                                        S   L   S   L   S   P               G   K  
  CS101556 IGHG4*01 F CH3-CHS gDNA     agc ctc tcc ctg tct ccg ... ... ... ggt aaa 

  JQ868731 IGHG4*02 F CH3-CHS gDNA     

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
30/01/2014
Last updated:
17/01/2017
Authors:
Saida Saljoqi, Perrine Pégorier