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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          A   T   K   T   A   P   T   I   F   P   L   N   A   Y   G   S 
  NW_001794226 IGHA2*01   F   CH1 gDNA                   gcg acc aag acc gca ccg acc atc ttc cca ctg aat gcc tac ggg tcc
                                                                                                                        
  AY055779     IGHA2*02   F   CH1 cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          N   S                   E   E   Q   V   S   I   G   C   L   V   R   G   Y   F 
  NW_001794226 IGHA2*01   F   CH1 gDNA   aac tcc ... ... ... ... gaa gaa caa gtg tcc att ggc tgc ctg gtc agg ggc tac ttc
                                                                                                                        
  AY055779     IGHA2*02   F   CH1 cDNA   --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P                   E   P   V   E   V   T   W   G   N   Q   A   S   S   A     
  NW_001794226 IGHA2*01   F   CH1 gDNA   cct ... ... ... ... gag ccg gtg gaa gtg acc tgg ggc aac cag gcc tcg tcc gca ...
                                                                                                                        
  AY055779     IGHA2*02   F   CH1 cDNA   --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                                      V   K   T   Y   P   A   V   L   E   S   N   G                     
  NW_001794226 IGHA2*01   F   CH1 gDNA   ... ... ... gtc aag acc tac cct gcc gtg ctg gag tcc aac ggg ... ... ... ... ...
                                                          R                                                             
  AY055779     IGHA2*02   F   CH1 cDNA   ... ... ... --- -g- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                                  Y   Y   L   V   S   S   M   L   T   L   P   A   N   Q   C           P 
  NW_001794226 IGHA2*01   F   CH1 gDNA   ... ... tac tac ctt gtg agc agc atg ctc acc ctc ccg gct aac cag tgc ... ... cct
                                                                                                                        
  AY055779     IGHA2*02   F   CH1 cDNA   ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ---


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          D   D   K   T   Y   Q   C   N   V   K   H   Y               D   S   S   K   T 
  NW_001794226 IGHA2*01   F   CH1 gDNA   gac gac aag acc tac caa tgc aat gtg aaa cac tac ... ... ... gat agc agc aaa acg
                                                                                                                        
  AY055779     IGHA2*02   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- ---


                                                                 
                                         
                                         120 121 122 123 124 125 
                                          A   N   V   K   C   R  
  NW_001794226 IGHA2*01   F   CH1 gDNA   gcc aac gtg aaa tgt aga 
                                                                 
  AY055779     IGHA2*02   F   CH1 cDNA   --- --- --- --- --- --- 




                                        1   2   3   4   5   6   7   8   9  
                                        G   P   V   S   N   C   G   C   E  
  NW_001794226 IGHA2*01   F   H gDNA   ggc cca gtt tca aac tgt gga tgt gaa 
                                                           
  AY055779     IGHA2*02   F   H gDNA   --- --- --- --- --- --- --- --- ---  




                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                  C   C   S   N   C   P   S   V   S   V   S   L   H   P   P   S   L   E 
  NW_001794226 IGHA2*01   F   CH2 gDNA           tgc tgc tca aac tgc cca tct gtg agt gtg tct ctg cac ccc ccg tcc ctg gaa

  AY055779     IGHA2*02   F   CH2 gDNA           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                             
                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          S   L   F   L           D   K   G   A   N   L   T   C   E   L   T   G   V   S 
  NW_001794226 IGHA2*01   F   CH2 gDNA   agc ctg ttc ctc ... ... gac aaa ggg gcc aac ctg acc tgt gaa cta acc ggg gtg agc

  AY055779     IGHA2*02   F   CH2 gDNA   agc ctg ttc ctc ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                    
                                                    
                                         _______BC___________________                            _____________CD_________
                                                                                              45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          N   V               K   G   V   N   F   S   W   S   P   L   S   G   T   A     
  NW_001794226 IGHA2*01   F   CH2 gDNA   aac gtt ... ... ... aaa ggg gta aac ttc tcc tgg tca ccg ctc tcc ggg acc gcc ...

  AY055779     IGHA2*02   F   CH2 gDNA   --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
                                                    
                                                    
                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                                      R   P   V   D   G   P   A   V   K   D   D   K                     
  NW_001794226 IGHA2*01   F   CH2 gDNA   ... ... ... agg ccc gtc gat ggc ccg gcg gtg aag gat gac aaa ... ... ... ... ...

  AY055779     IGHA2*02   F   CH2 gDNA   ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
                                                    
                                                    
                                          ____________                                                ___EF___            
                                              85.2                                                    96.1                
                                          85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                              G   K   Y   T   I   T   S   T   L   E   V   C   T   D   E   W           M 
  NW_001794226 IGHA2*01   F   CH2 gDNA   ... ggc aag tac acc atc acc agc acc ctg gag gtc tgc acc gat gag tgg ... ... atg

  AY055779     IGHA2*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ---
                                                    
                                                    
                                                             _________________________FG_________________________        
                                        
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          R   G   D   K   Y   T   C   T   V   S   H   P   E           L   P   K   P   V 
  NW_001794226 IGHA2*01   F   CH2 gDNA   cgg gga gac aaa tac acc tgc acc gta agc cac ccg gaa ... ... ctg ccc aaa ccc gtc

  AY055779     IGHA2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- ---
                                                    
                                                    
                                                                            
                                         121 122 123 124 125 126 127 128 
                                          T   K   T   I   T   K   V   S  
  NW_001794226 IGHA2*01   F   CH2 gDNA   acc aaa acc atc acc aag gtt tct 

  AY055779     IGHA2*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- 
 
 
 

                                                                                                                            
                                             
                                             1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                              G   P   L   F   R   P   E   V   H   L   L   A   P   T   A   E 
  NW_001794226 IGHA2*01   F   CH3-CHS gDNA                   ggc ccc ctg ttc cga cct gag gtc cac ctg ctg gcc cct acc gcc gag
                                                                                                                            
  AY055779     IGHA2*02   F   CH3-CHS cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                         _____AB_____                                            ____________
                                                         15.1    15.3                                                        
                                              13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                              E   L   A   L           N   E   L   A   T   L   T   C   L   V   R   G   F   S 
  NW_001794226 IGHA2*01   F   CH3-CHS gDNA   gag ctg gcc ctg ... ... aat gag ttg gcc act ctg acc tgc ctg gtg agg ggt ttc agc
                                                                                                                            
  AY055779     IGHA2*02   F   CH3-CHS cDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                             _______BC___________________                            _____________CD_________
                                                                                                     45.1    45.3    45.5    
                                              30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                              P                   K   E   L   M   V   K   W   L   K   G   G   Q   E   V   P 
  NW_001794226 IGHA2*01   F   CH3-CHS gDNA   ccc ... ... ... ... aag gaa ctg atg gtg aaa tgg ctg aag ggg ggt cag gag gtg ccc
                                                                                                                            
  AY055779     IGHA2*02   F   CH3-CHS cDNA   --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                             ____                                ___________________________DE_______________
                                             45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                                  77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              R   K       D   Y   V   T   G   S   P   Q   R   E   V   S   E   G             
  NW_001794226 IGHA2*01   F   CH3-CHS gDNA   cgg aag ... gac tat gtg acc ggc tcc ccg cag cgg gag gtc agc gag ggc ... ... ...
                                                                                                                            
  AY055779     IGHA2*02   F   CH3-CHS cDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                             ____________                                                ___EF___            
                                                 85.2                                                    96.1                
                                             85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                              S   A   T   F   F   L   Y   S   T   L   R   V   Q   T   S   T   W           K 
  NW_001794226 IGHA2*01   F   CH3-CHS gDNA   tcc gcc acg ttc ttc ctg tac agc acc ctc cgc gtc cag acc tct acc tgg ... ... aaa
                                                                                                                            
  AY055779     IGHA2*02   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ---


                                                                 _________________________FG_________________________        
                                             
                                             100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                              E   G   E   N   F   S   C   V   V   G   H   E   S       L   P   L   N   F   T 
  NW_001794226 IGHA2*01   F   CH3-CHS gDNA   gag ggg gag aac ttc tcc tgt gta gtg ggc cac gag tcc ... ctg ccc ctc aac ttc acc
                                                                                                                            
  AY055779     IGHA2*02   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- ---


                                                                                         ________________________________CHS
                                             
                                             120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                              Q   K   T   F   D   H   S   T               G   K   P   S   T   V   N   L   T 
  NW_001794226 IGHA2*01   F   CH3-CHS gDNA   cag aaa acc ttc gac cac tcc acc ... ... ... ggt aaa ccc agc acg gtc aac ctg acc
                                                                                                                            
  AY055779     IGHA2*02   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- ---


                                             ____________________________________________
                                             
                                             140 141 142 143 144 145 146 147 148 149 150 
                                              V   V   M   S   D   A   A   N   T   C   Y  
  NW_001794226 IGHA2*01   F   CH3-CHS gDNA   gtg gtc atg tcc gac gcg gcc aac acc tgt tac 
                                                                                         
  AY055779     IGHA2*02   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- 

                                     

                                       
                                        1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                        G   P   E   C   Y   C   P   T   T   V   A   C   C   S   F   P   K   L   P   V 
  NW_001794226 IGHA2*01   F   M gDNA   gga cct gaa tgc tac tgt ccg acc acc gtg gcc tgc tgt tca ttc ccg aag tta cca gtg


                                       
                                       
                                        21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                        V   D   E   G   G   V   E   E   T   D   Q   E   S   T   L   W   P   T   S   V 
  NW_001794226 IGHA2*01   F   M gDNA   gtg gat gag gga gga gtg gag gaa aca gac cag gag tcc aca cta tgg ccc aca tca gtc


                                       
                                       
                                        41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                        T   F   L   T   L   F   L   L   S   L   F   Y   S   T   T   V   T   L   F   K 
  NW_001794226 IGHA2*01   F   M gDNA   acc ttc ctt acc ctg ttc cta ctc agc ttg ttc tac agc aca aca gtg acg ctc ttc aag


                                       
                                       
                                        61  62  63  64  65  66  67  68  69 
                                        V   K   P   L   S   P   I   K   Y  
  NW_001794226 IGHA2*01   F   M gDNA   gtg aag cct ctg tcg ccc atc aaa tat 

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
25/11/2014
Last updated:
27/05/2016
Authors:
Saida Saljoqi