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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	
                                                                                                                                             
                                                             
                                                             1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                                          G   Q   P   V   V   T   P   S   L   T   L   F   P   P   S   S   E 
  M12763       IGLC4*01 F lambda-chain C-region C-lambda-4   ... ... ... ggt caa ccc gta gtc act cct tca ctc act ctg ttc ccg ccc tcc tct gag
                                                                                                                                            
  NW_003159316 IGLC4*02 F                                    ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                                         _____AB_____                                            ____________
                                                                         15.1    15.3                                                        
                                                              13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                                              E   L   K               D   N   K   A   T   L   V   C   L   I   N   D   F   Y 
  M12763       IGLC4*01 F lambda-chain C-region C-lambda-4   gaa ctc aag ... ... ... gac aac aag gcc aca cta gtg tgt ctg atc aat gac ttc tac
                                                                                                                                            
  NW_003159316 IGLC4*02 F                                    --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                             _______BC___________________                            _____________CD_________
                                                                                                                     45.1    45.3    45.5    
                                                              30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                                              P           G   T   L   T   V   N   W   K   A   D   G   T   S   I   T   Q     
  M12763       IGLC4*01 F lambda-chain C-region C-lambda-4   ccg ... ... ggc acc ctg acg gtg aac tgg aag gca gat ggc acc tcc atc acc cag ...
                                                                                  V                                                         
  NW_003159316 IGLC4*02 F                                    --- ... ... --- --- g-- --- --- --- --- --- --- --- --- --- --- --- --- --- ...


                                                             ____                                ___________________________DE_______________
                                                             45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                                                  77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                                                  G   M   D   T   T   Q   P   S   K   Q   S   N                           N 
  M12763       IGLC4*01 F lambda-chain C-region C-lambda-4   ... ggc atg gac acc acc cag ccc tcc aaa cag agc aac ... ... ... ... ... ... aac
                                                                                                      E                                     
  NW_003159316 IGLC4*02 F                                    ... --- --- --- --- --- --- --- --- --- g-- --- --- ... ... ... ... ... ... ---


                                                             ____________                                                ___EF___            
                                                                 85.2                                                    96.1                
                                                             85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                                              K   Y   A   A   S   S   F   L   S   L   S   A   N   Q   W           K   S   Y 
  M12763       IGLC4*01 F lambda-chain C-region C-lambda-4   aag tac gcg gcc agc agc ttc ctc agc ctg tca gcc aat cag tgg ... ... aaa tcc tac
                                                                                                                                            
  NW_003159316 IGLC4*02 F                                    --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                                                 _________________________FG_________________________        
                                                             
                                                             100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                                              Q   R   A   T   C   Q   V   T   H   E                   G   Q   A   M   E   R 
  M12763       IGLC4*01 F lambda-chain C-region C-lambda-4   cag aga gcc acc tgc cag gtc aca cac gag ... ... ... ... ggc caa gcc atg gag agg
                                                                                                                                            
  NW_003159316 IGLC4*02 F                                    --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---


                                                                                             
                                                             
                                                             120 121 122 123 124 125 126 127 
                                                              S   L   V   P   A   E   C   S  
  M12763       IGLC4*01 F lambda-chain C-region C-lambda-4   agc ctg gtc cct gca gaa tgc tcc 
                                                                                             
  NW_003159316 IGLC4*02 F                                    --- --- --- --- --- --- --- --- 

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
28/09/2012
Last updated:
27/05/2016
Authors:
Fatena Bellahcene