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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                                                    
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                      A   P   K   T   A   P   S   V   Y   P   L   A   P   C   S   R 
  U03779   IGHG2*01   F   CH1 cDNA                   gcc ccc aag acg gcc cca tcg gtc tac cct ctg gcc ccc tgc agc agg
                                                                                                                    
  M81769   IGHG2*02   F   CH1 cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                              L                               G     
  U03780   IGHG2*03   F   CH1 cDNA                   --- --- --- --- --- --- -t- --- --- --- --- --- --- --- g-- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   T   S               G   P   N   V   A   L   G   C   L   A   S   S   Y   F 
  U03779   IGHG2*01   F   CH1 cDNA   gac acg tct ... ... ... ggc cct aac gtg gcc ttg ggc tgc ctg gcc tca agc tac ttc
                                                                                                                    
  M81769   IGHG2*02   F   CH1 cDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  U03780   IGHG2*03   F   CH1 cDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      P           E   P   V   T   V   T   W   N   S   G   A   L   S   S             
  U03779   IGHG2*01   F   CH1 cDNA   ccc ... ... gag cca gtg acc gtg acc tgg aac tcg ggc gcc ctg tcc agt ... ... ...
                                                                              T                                     
  M81769   IGHG2*02   F   CH1 cDNA   --- ... ... --- --- --- --- --- --- --- -c- --- --- --- --- --- --- ... ... ...
                                                                                                  T                 
  U03780   IGHG2*03   F   CH1 cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- a-- --- ... ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          G   V   H   T   F   P   S   V   L   Q   P   S                           G 
  U03779   IGHG2*01   F   CH1 cDNA   ... ggc gtg cat acc ttc cca tcc gtc ctg cag ccg tca ... ... ... ... ... ... ggg
                                                                                                                    
  M81769   IGHG2*02   F   CH1 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  U03780   IGHG2*03   F   CH1 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      L   Y   S   L   S   S   M   V   T   V   P   A   S   S   L               S   S 
  U03779   IGHG2*01   F   CH1 cDNA   ctc tac tcc ctc agc agc atg gtg acc gtg ccg gcc agc agc ctg ... ... ... tcc agc
                                                                                                                    
  M81769   IGHG2*02   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
                                                                                                                    
  U03780   IGHG2*03   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   S   Y   T   C   N   V   N   H   P   A           T   T   T   K   V   D   K 
  U03779   IGHG2*01   F   CH1 cDNA   aag agc tac acc tgc aat gtc aac cac ccg gcc ... ... acc acc acc aag gtg gac aag
                                                  S                                                                 
  M81769   IGHG2*02   F   CH1 cDNA   --- --- --- -g- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  U03780   IGHG2*03   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                             
                                     
                                     120 121 
                                      R   V  
  U03779   IGHG2*01   F   CH1 cDNA   cgt gtt 
                                             
  M81769   IGHG2*02   F   CH1 cDNA   --- --- 
                                             
  U03780   IGHG2*03   F   CH1 cDNA   --- --- 




                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12 
                                    G   T   K   T   K   P   P   C   P   I   C   P  
  U03779   IGHG2*01   F   H cDNA   gga aca aag acc aaa cca cca tgt ccc ata tgc cca 
                                                                                   
  M81769   IGHG2*02   F   H cDNA   --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                   
  U03780   IGHG2*03   F   H cDNA   --- --- --- --- --- --- --- --- --- --- --- --- 




                                                                                                                    
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                  A   C   E   S   P   G   P   S   V   F   I   F   P   P   K   P   K 
  U03779   IGHG2*01   F   CH2 cDNA               gcc tgt gaa tca cca ggg ccc tcg gtc ttc atc ttc cct cca aaa ccc aag
                                                                                                                    
  M81769   IGHG2*02   F   CH2 cDNA               --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  U03780   IGHG2*03   F   CH2 cDNA               --- --- --- --g --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   T   L   M   I       S   R   T   P   Q   V   T   C   V   V   V   D   V   S 
  U03779   IGHG2*01   F   CH2 cDNA   gac acc ctc atg atc ... tcc cgg aca ccc cag gtc acg tgc gtg gtg gtt gat gtg agc
                                                                                                                    
  M81769   IGHG2*02   F   CH2 cDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                    
  U03780   IGHG2*03   F   CH2 cDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --a --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      Q   E   N   P   E   V   Q   F   S   W   Y   V   D   G   V   E   V   H         
  U03779   IGHG2*01   F   CH2 cDNA   cag gag aac ccg gag gtc cag ttc tcc tgg tac gtg gac ggc gta gag gtg cac ... ...
                                                                                                                    
  M81769   IGHG2*02   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                    
  U03780   IGHG2*03   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          T   A   Q   T   R   P   K   E   E   Q   F   N                           S 
  U03779   IGHG2*01   F   CH2 cDNA   ... acg gcc cag acg agg cca aag gag gag cag ttc aac ... ... ... ... ... ... agc
                                                                                                                    
  M81769   IGHG2*02   F   CH2 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                    
  U03780   IGHG2*03   F   CH2 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      T   Y   R   V   V   S   V   L   P   I   Q   H   Q   D   W           L   N   G 
  U03779   IGHG2*01   F   CH2 cDNA   acc tac cgc gtg gtc agc gtc cta ccc atc cag cac cag gac tgg ... ... ctg aac ggg
                                                                                                                    
  M81769   IGHG2*02   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                    
  U03780   IGHG2*03   F   CH2 cDNA   --- --- --- --- --- --- --- --g --- --- --- --- --- --- --- ... ... --- --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   E   F   K   C   K   V   N   N   K   D           L   P   A   P   I   T   R 
  U03779   IGHG2*01   F   CH2 cDNA   aag gag ttc aag tgc aag gtc aac aac aaa gac ... ... ctc cca gcc ccc atc aca agg
                                      P                                                                             
  M81769   IGHG2*02   F   CH2 cDNA   cc- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                    
  U03780   IGHG2*03   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                             
                                     
                                     120 121 122 123 124 125 
                                      I   I   S   K   A   K  
  U03779   IGHG2*01   F   CH2 cDNA   atc atc tcc aag gcc aaa 
                                                             
  M81769   IGHG2*02   F   CH2 cDNA   --- --- --- --- --- --- 
                                                             
  U03780   IGHG2*03   F   CH2 cDNA   --- --- --- --- --- --- 





                                                                                                                       
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          G   Q   T   R   E   P   Q   V   Y   T   L   P   P   H   A   E 
  U03779   IGHG2*01   F   CH3-CHS cDNA                   ggg cag acc cgg gag ccg cag gtg tac acc ctg ccc cca cac gcc gag
                                                                                                                        
  M81769   IGHG2*02   F   CH3-CHS cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  U03780   IGHG2*03   F   CH3-CHS cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          E   L   S               R   S   K   V   S   I   T   C   L   V   I   G   F   Y 
  U03779   IGHG2*01   F   CH3-CHS cDNA   gag ctg tcc ... ... ... agg agc aaa gtc agc ata acc tgc ctg gtc att ggc ttc tac
                                                                                                                        
  M81769   IGHG2*02   F   CH3-CHS cDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                        
  U03780   IGHG2*03   F   CH3-CHS cDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           P   D   I   D   V   E   W   Q   R   N   G   Q   P   E   P   E   G 
  U03779   IGHG2*01   F   CH3-CHS cDNA   cca ... ... cct gac atc gat gtc gag tgg caa aga aac gga cag ccg gag cca gag ggc
                                                                                                              L         
  M81769   IGHG2*02   F   CH3-CHS cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- -t- --- ---
                                                                                                                        
  U03780   IGHG2*03   F   CH3-CHS cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              N   Y   R   T   T   P   P   Q   Q   D   V   D                           G 
  U03779   IGHG2*01   F   CH3-CHS cDNA   ... aat tac cgc acc acc ccg ccc cag cag gac gtg gac ... ... ... ... ... ... ggg
                                                                                                                        
  M81769   IGHG2*02   F   CH3-CHS cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                        
  U03780   IGHG2*03   F   CH3-CHS cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          T   Y   F   L   Y   S   K   F   S   V   D   K   A   S   W           Q   G   G 
  U03779   IGHG2*01   F   CH3-CHS cDNA   acc tac ttc ctg tac agc aag ttc tcg gtg gac aag gcc agc tgg ... ... cag ggt gga
                                                                                                                        
  M81769   IGHG2*02   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                        
  U03780   IGHG2*03   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                             _________________________FG_________________________        
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          G   I   F   Q   C   A   V   M   H   E   A       L   H   N   H   Y   T   Q   K 
  U03779   IGHG2*01   F   CH3-CHS cDNA   ggc ata ttc cag tgt gcg gtg atg cac gag gct ... ctg cac aac cac tac acc cag aag
                                                                                                                        
  M81769   IGHG2*02   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                        
  U03780   IGHG2*03   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                             __CHS___
                                         
                                         120 121 122 123 124 125 126 127 128 129 130 
                                          S   I   S   K   T   P               G   K  
  U03779   IGHG2*01   F   CH3-CHS cDNA   tct atc tcc aag act ccg ... ... ... ggt aaa 
                                                                                     
  M81769   IGHG2*02   F   CH3-CHS cDNA   --- --- --- --- --- --- ... ... ... --- --- 
                                                                                     
  U03780   IGHG2*03   F   CH3-CHS cDNA   --- --- --- --- --- --- ... ... ... --- --- 

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
17/09/2014
Last updated:
27/05/2016
Authors:
Saida Saljoqi