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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                                                     
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                      A   P   K   T   A   P   S   V   Y   P   L   A   P   C   G   R 
  EU372654 IGHG4*01   F   CH1 gDNA                   gcc ccc aag acg gcc cca tcg gtc tac cct ctg gcc ccc tgc ggc agg
                                      

                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   V   S               G   P   N   V   A   L   G   C   L   A   S   S   Y   F 
  EU372654 IGHG4*01   F   CH1 gDNA   gac gtg tct ... ... ... ggc cct aac gtg gcc ttg ggc tgc ctg gcc tca agc tac ttc


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      P           E   P   V   T   V   T   W   N   S   G   A   L   T   S             
  EU372654 IGHG4*01   F   CH1 gDNA   ccc ... ... gag cca gtg acc gtg acc tgg aac tcg ggc gcc ctg acc agt ... ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          G   V   H   T   F   P   S   V   L   Q   P   S                           G 
  EU372654 IGHG4*01   F   CH1 gDNA   ... ggc gtg cac acc ttc cca tcc gtc ctg cag ccg tca ... ... ... ... ... ... ggg
                                                                                                                    
  U03782   IGHG4*02   F   CH1 cDNA                -t --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      L   Y   S   L   S   S   M   V   T   V   P   A   S   S   L               S   S 
  EU372654 IGHG4*01   F   CH1 gDNA   ctc tac tcc ctc agc agc atg gtg acc gtg ccg gcc agc agc ctg ... ... ... tcc agc
                                                                                                                    
  U03782   IGHG4*02   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   S   Y   T   C   N   V   N   H   P   A           T   T   T   K   V   D   K 
  EU372654 IGHG4*01   F   CH1 gDNA   aag agc tac acc tgc aat gtc aac cac ccg gcc ... ... acc acc acc aag gtg gac aag
                                                                                                                    
  U03782   IGHG4*02   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                             
                                     
                                     120 121 
                                      R   V  
  EU372654 IGHG4*01   F   CH1 gDNA   cgt gtt 
                                             
  U03782   IGHG4*02   F   CH1 cDNA   --- --- 




                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12 
                                    G   I   H   Q   P   Q   T   C   P   I   C   P  
  EU372654 IGHG4*01   F   H gDNA   gga ata cac cag ccg caa aca tgt ccc ata tgc cca 
                                        T   K   T   K   P   P                      
  U03782   IGHG4*02   F   H cDNA   --- -c- a-g acc aaa -c- c-- --- --- --- --- ---  
                                                                                                                                                                                                                                                               
                                                                                                                                                                                                                                                                                                                      



                                                                                                                     
                                     
                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                  A   C   E   G   P   G   P   S   A   F   I   F   P   P   K   P   K 
  EU372654 IGHG4*01   F   CH2 gDNA               gcc tgt gaa ggg ccc ggg ccc tcg gcc ttc atc ttc cct cca aaa ccc aag
                                                                                                                    
  U03782   IGHG4*02   F   CH2 cDNA               --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3                                                        
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   T   L   M   I       S   R   T   P   K   V   T   C   V   V   V   D   V   S 
  EU372654 IGHG4*01   F   CH2 gDNA   gac acc ctc atg atc ... tcc cgg acc ccc aag gtc acg tgc gtg gtg gtt gat gtg agc
                                                                                                                    
  U03782   IGHG4*02   F   CH2 cDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --a --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5    
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      Q   E   N   P   E   V   Q   F   S   W   Y   V   D   G   V   E   V   H         
  EU372654 IGHG4*01   F   CH2 gDNA   cag gag aac ccg gag gtc cag ttc tcc tgg tac gtg gac ggc gta gag gtg cac ... ...
                                                                                                                    
  U03782   IGHG4*02   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                          T   A   Q   T   R   P   K   E   E   Q   F   N                           S 
  EU372654 IGHG4*01   F   CH2 gDNA   ... acg gcc cag acg agg cca aag gag gag cag ttc aac ... ... ... ... ... ... agc
                                                                                                                    
  U03782   IGHG4*02   F   CH2 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1                
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      T   Y   R   V   V   S   V   L   L   I   Q   H   Q   D   W           L   N   G 
  EU372654 IGHG4*01   F   CH2 gDNA   acc tac cgc gtg gtc agc gtc ctg ctc atc cag cac cag gac tgg ... ... ctg aac ggg
                                                                      P                                             
  U03782   IGHG4*02   F   CH2 cDNA   --- --- --- --- --- --- --- --- -c- --- --- --- --- --- --- ... ... --- --- ---


                                                         _________________________FG_________________________        
                                     
                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   E   F   K   C   K   V   N   N   K   D           L   P   A   P   I   T   R 
  EU372654 IGHG4*01   F   CH2 gDNA   aag gag ttc aag tgc aag gtc aac aac aaa gac ... ... ctc cca gcc ccc atc aca agg
                                                                                                                    
  U03782   IGHG4*02   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                             
                                     
                                     120 121 122 123 124 125 
                                      I   I   S   K   A   K  
  EU372654 IGHG4*01   F   CH2 gDNA   atc atc tcc aag gcc aaa 
                                                             
  U03782   IGHG4*02   F   CH2 cDNA   --- --- --- --- --- --- 




                                                                                                                        
                                         
                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          G   Q   T   R   E   P   Q   V   Y   T   L   P   P   P   T   E 
  EU372654 IGHG4*01   F   CH3-CHS gDNA                   ggg cag acc cgg gag ccg cag gtg tac acc ctg ccc cca ccc acc gag
                                                                                                                        
  U03782   IGHG4*02   F   CH3-CHS cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                     _____AB_____                                            ____________
                                                     15.1    15.3                                                        
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          E   L   S               R   S   K   V   T   L   T   C   L   V   T   G   F   Y 
  EU372654 IGHG4*01   F   CH3-CHS gDNA   gag ctg tcc ... ... ... agg agc aaa gtc acg cta acc tgc ctg gtc act ggc ttc tac
                                                                                                                        
  U03782   IGHG4*02   F   CH3-CHS cDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5    
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           P   D   I   D   V   E   W   Q   R   N   G   Q   P   E   P   E   G 
  EU372654 IGHG4*01   F   CH3-CHS gDNA   cca ... ... cct gac atc gat gtc gag tgg caa aga aac gga cag ccg gag cca gag ggc
                                                                                                                        
  U03782   IGHG4*02   F   CH3-CHS cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                              N   Y   R   T   T   P   P   Q   Q   D   V   D                           G 
  EU372654 IGHG4*01   F   CH3-CHS gDNA   ... aat tac cgc acc acc ccg ccc cag cag gac gtg gac ... ... ... ... ... ... ggg
                                                                                                                        
  U03782   IGHG4*02   F   CH3-CHS cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1                
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          T   Y   F   L   Y   S   K   L   A   V   D   K   A   S   W           Q   R   G 
  EU372654 IGHG4*01   F   CH3-CHS gDNA   acc tac ttc ctg tac agc aag ctc gcg gtg gac aag gcc agc tgg ... ... cag cgt gga
                                                                                                                        
  U03782   IGHG4*02   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                             _________________________FG_________________________    
                                         
                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 
                                          D   T   F   Q   C   A   V   M   H   E   A       L   H   N   H   Y   T  
  EU372654 IGHG4*01   F   CH3-CHS gDNA   gac aca ttc cag tgt gcg gtg atg cac gag gct ... ctg cac aac cac tac acc c
                                                                                                                  Q   K 
  U03782   IGHG4*02   F   CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- -ag aag


                                         
                                         
                                         
                                                                             __CHS___
                                                                         
                                          S   I   F   K   T   P               G   K  
  U03782   IGHG4*02   F   CH3-CHS cDNA   tcc atc ttc aag act ccg ... ... ... ggt aaa 

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
17/09/2014
Last updated:
27/05/2016
Authors:
Saida Saljoqi