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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	                                                                                                                  
                                    
                                    1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                     E   S   Q   S   A   P   N   L   F   P   L   V   S   C   V   S 
  AB699686 IGHM*01   F   CH1 gDNA                   gag agc cag tct gcc ccg aat ctc ttc ccc ctc gtc tcc tgc gtc agc
                                                                                     Y                             
  U50149   IGHM*02   F   CH1 gDNA                   --- --- --- --- --- --- --- --- -a- --- --- --- --- --- --- ---


                                                _____AB_____                                            ____________
                                                15.1    15.3                                                        
                                     13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                     P   P   S   D           E   S   L   V   A   L   G   C   L   A   R   D   F   L 
  AB699686 IGHM*01   F   CH1 gDNA   ccc ccg tcc gat ... ... gag agc ctg gtg gcc ctg ggc tgc ctg gcc cgg gac ttc ctg
                                                                                                                   
  U50149   IGHM*02   F   CH1 gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    _______BC___________________                            _____________CD_________
                                                                                            45.1    45.3    45.5    
                                     30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                     P           S   S   V   T   F   S   W   N   Y   K   N   S   S   K   V   S   S 
  AB699686 IGHM*01   F   CH1 gDNA   ccc ... ... agc tcc gtc acc ttc tcc tgg aac tac aag aac agc agc aag gtc agc agc
                                                                                                                   
  U50149   IGHM*02   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH1 cDNA                                                                                --


                                    ____                                ___________________________DE_______________
                                    45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                         77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     Q   N   I   Q   D   F   P   S   V   L   R   G   G                             
  AB699686 IGHM*01   F   CH1 gDNA   cag aac atc cag gac ttc ccg tcc gtc ctg aga ggc ggc ... ... ... ... ... ... ...
                                                                                                                   
  U50149   IGHM*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
                                                                                                                   
  M92050   IGHM*03   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...


                                    ____________                                                ___EF___            
                                        85.2                                                    96.1                
                                    85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                     K   Y   L   A   S   S   R   V   L   L   P   S   V   S   I   P   Q   D   P   E 
  AB699686 IGHM*01   F   CH1 gDNA   aag tac ttg gcc tcc tcc cgg gtg ctc cta ccc tct gtg agc atc ccc cag gac cca gag
                                                                                                                   
  U50149   IGHM*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                        _________________________FG_________________________        
                                    
                                    100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                     A   F   L   V   C   E   V   Q   H   P                   S   G   T   K   S   V 
  AB699686 IGHM*01   F   CH1 gDNA   gcc ttc ctg gtg tgc gag gtc cag cac ccc ... ... ... ... agt ggc acc aag tcc gtg
                                                                                                                   
  U50149   IGHM*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH1 cDNA   --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---


                                                        
                                    
                                    120 121 122 123 124 
                                     S   I   S   G   P  
  AB699686 IGHM*01   F   CH1 gDNA   tcc atc tct ggg cca 
                                                        
  U50149   IGHM*02   F   CH1 gDNA   --- --- --- --- --- 
                                                        
  M92050   IGHM*03   F   CH1 cDNA   --- --- --- --- --- 

                                                                                                                    
                                    
                                    1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 V   V   E   E   Q   P   P   V   L   N   I   F   V   P   T   R   E 
  AB699686 IGHM*01   F   CH2 gDNA               gtc gta gag gag cag ccc ccc gtc ttg aac atc ttc gtc ccc acc cgg gag
                                                                                                                   
  U50149   IGHM*02   F   CH2 gDNA               --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH2 cDNA               --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                _____AB_____                                            ____________
                                                15.1    15.3                                                        
                                     13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                     S   F   S   S   T   P   Q   R   T   S   K   L   I   C   Q   A   S   D   F   S 
  AB699686 IGHM*01   F   CH2 gDNA   tcc ttc tcc agt act ccc cag cgc acg tcc aag ctc atc tgc cag gcc tca gac ttc agc
                                                                                                                   
  U50149   IGHM*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    _______BC___________________                            _____________CD_________
                                                                                            45.1    45.3    45.5    
                                     30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                     P           K   Q   I   S   M   A   W   F   R   D   G   K   R   V   V   S     
  AB699686 IGHM*01   F   CH2 gDNA   ccc ... ... aag cag atc tcc atg gcc tgg ttc cgt gat ggg aaa cgg gtg gtg tct ...
                                                                                                                   
  U50149   IGHM*02   F   CH2 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
                                                                                                                   
  M92050   IGHM*03   F   CH2 cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...


                                    ____                                ___________________________DE_______________
                                    45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                         77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                         G   V   S   T   G   P   V   E   T   L   Q   S   S                   P   V 
  AB699686 IGHM*01   F   CH2 gDNA   ... ggc gtc agc aca ggc ccc gtg gag acc cta cag tcc agt ... ... ... ... ccg gtg
                                                                                                                   
  U50149   IGHM*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---
                                                         A                                                         
  M92050   IGHM*03   F   CH2 cDNA   ... --- --- --- --- -c- --- --- --- --- --- --- --- --- ... ... ... ... --- ---


                                    ____________                                                ___EF___            
                                        85.2                                                    96.1                
                                    85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                     T   Y   R   L   H   S   M   L   T   V   T   E   S   E   W           L   S   Q 
  AB699686 IGHM*01   F   CH2 gDNA   acc tac agg ctc cac agc atg ctg acc gtc acg gag tcc gag tgg ... ... ctc agc cag
                                                                                                                   
  U50149   IGHM*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                        _________________________FG_________________________        
                                    
                                    100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                     S   V   F   T   C   Q   V   E   H   K                   G   L   N   Y   E   K 
  AB699686 IGHM*01   F   CH2 gDNA   agc gtc ttc acc tgc cag gtg gag cac aaa ... ... ... ... ggg ctg aac tac gag aag
                                                                                                                   
  U50149   IGHM*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH2 cDNA   --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---


                                                                    
                                    
                                    120 121 122 123 124 125 126 127 
                                     N   A   S   S   L   C   T   S  
  AB699686 IGHM*01   F   CH2 gDNA   aac gcg tcc tct ctg tgc acc tcc 
                                                                    
  U50149   IGHM*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- 
                                                                    
  M92050   IGHM*03   F   CH2 cDNA   --- --- --- --- --- --- --- ---

                                                                                                                    
                                    
                                    1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                     N   P   N   S   P   I   T   V   F   A   I   A   P   S   F   A 
  AB699686 IGHM*01   F   CH3 gDNA                   aat ccc aac tct ccc atc acc gtc ttc gcc atc gcc ccc tcc ttc gct
                                                                                                                   
  U50149   IGHM*02   F   CH3 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH3 cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                _____AB_____                                            ____________
                                                15.1    15.3                                                        
                                     13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                     G   I   F   L           T   K   S   A   K   L   S   C   L   V   T   G   L   V 
  AB699686 IGHM*01   F   CH3 gDNA   ggc atc ttc ctc ... ... acc aag tcg gcc aag ctt tcc tgc ctg gtc acg ggc ctc gtc
                                                                                                                   
  U50149   IGHM*02   F   CH3 gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH3 cDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                    _______BC___________________                            _____________CD_________
                                                                                            45.1    45.3    45.5    
                                     30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                     T   R       E   S   L   N   I   S   W   T   R   Q   D   G   E   V   L         
  AB699686 IGHM*01   F   CH3 gDNA   acc agg ... gag agc ctc aac atc tcc tgg acc cgc cag gac ggc gag gtt ctg ... ...
                                                                                                                   
  U50149   IGHM*02   F   CH3 gDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                   
  M92050   IGHM*03   F   CH3 cDNA   --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                    ____                                ___________________________DE_______________
                                    45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                         77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                         K   T   S   I   V   F   S   E   I   Y   A   N                           G 
  AB699686 IGHM*01   F   CH3 gDNA   ... aag acc agt atc gtc ttc tct gag atc tac gcc aac ... ... ... ... ... ... ggc
                                                                                                                   
  U50149   IGHM*02   F   CH3 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                 R 
  M92050   IGHM*03   F   CH3 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... c-a


                                    ____________                                                ___EF___            
                                        85.2                                                    96.1                
                                    85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                     T   F   G   A   R   G   E   A   S   V   C   V   E   D   W           E   S   G 
  AB699686 IGHM*01   F   CH3 gDNA   acc ttc ggc gcc agg ggc gaa gcc tcc gtc tgc gtg gag gac tgg ... ... gag tcg ggc
                                                                                                                   
  U50149   IGHM*02   F   CH3 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                     A                                                                             
  M92050   IGHM*03   P   CH3 cDNA   g-- --- --- ..- --. --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                        _________________________FG_________________________        
                                    
                                    100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                     D   R   F   T   C   T   V   T   H   T   D           L   P   S   P   L   K   Q 
  AB699686 IGHM*01   F   CH3 gDNA   gac agg ttc acg tgc acg gtg acc cac acg gac ... ... ctg ccc tcg ccg ctg aag cag
                                                                                                                   
  U50149   IGHM*02   F   CH3 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                   
  M92050   IGHM*03   F   CH3 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                            
                                    
                                    120 121 122 123 124 125 
                                     S   V   S   K   P   R  
  AB699686 IGHM*01   F   CH3 gDNA   agc gtc tcc aag ccc aga 
                                                            
  U50149   IGHM*02   F   CH3 gDNA   --- --- --- --- --- --- 
                                                            
  M92050   IGHM*03   F   CH3 cDNA   --- --- --- --- --- --- 


                                                                                                                        
                                        
                                        1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                     G   I   A   R   H   M   P   S   V   Y   V   L   P   P   A   P   E 
  AB699686 IGHM*01   F   CH4-CHS gDNA               ggg atc gcc agg cac atg ccg tcc gtg tac gtg ctg ccg ccg gcc ccg gag
                                                                                                                       
  U50149   IGHM*02   F   CH4-CHS gDNA               --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                       
  M92050   IGHM*03   F   CH4-CHS cDNA               --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                    _____AB_____                                            ____________
                                                    15.1    15.3                                                        
                                         13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                         E   L   S   L           Q   E   W   A   S   V   T   C   L   V   K   G   F   S 
  AB699686 IGHM*01   F   CH4-CHS gDNA   gag ctg agc ctg ... ... cag gag tgg gcc tcg gtc acc tgc ctg gtg aag ggc ttc tcc
                                                                                                                       
  U50149   IGHM*02   F   CH4-CHS gDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                       
  M92050   IGHM*03   F   CH4-CHS cDNA   --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                        _______BC___________________                            _____________CD_________
                                                                                                45.1    45.3    45.5    
                                         30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                         P           A   D   V   F   V   Q   W   L   Q   K   G   E   P   V   S   A   D 
  AB699686 IGHM*01   F   CH4-CHS gDNA   ccg ... ... gcg gac gtg ttc gtg cag tgg ctg cag aag ggg gag ccc gtg tcc gcc gac
                                                                                                                       
  U50149   IGHM*02   F   CH4-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                       
  M92050   IGHM*03   F   CH4-CHS cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                        ____                                ___________________________DE_______________
                                        45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                             77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                             K   Y   V   T   S   A   P   V   P   E   P   E   P   K           A   P   A 
  AB699686 IGHM*01   F   CH4-CHS gDNA   ... aag tac gtg acc agc gcg ccg gtg ccc gag ccc gag ccc aag ... ... gcc ccc gcc
                                                                                                                       
  U50149   IGHM*02   F   CH4-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                       
  M92050   IGHM*03   F   CH4-CHS cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                        ____________                                                ___EF___            
                                            85.2                                                    96.1                
                                        85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                         S   Y   F   V   Q   S   V   L   T   V   S   A   K   D   W           S   D   G 
  AB699686 IGHM*01   F   CH4-CHS gDNA   tcc tac ttc gtg cag agc gtc ctg acg gtg agc gcc aag gac tgg ... ... agc gac ggg
                                                                                                                       
  U50149   IGHM*02   F   CH4-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                       
  M92050   IGHM*03   F   CH4-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                            _________________________FG_________________________        
                                        
                                        100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                         E   T   Y   T   C   V   V   G   H   E   A       L   P   H   T   V   T   E   R 
  AB699686 IGHM*01   F   CH4-CHS gDNA   gag acc tac acc tgc gtc gtg ggc cac gag gcc ... ctg ccc cac acg gtg acc gag agg
                                                                                                                       
  U50149   IGHM*02   F   CH4-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                       
  M92050   IGHM*03   F   CH4-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                            ______________________________________CHS___
                                        
                                        120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                         T   V   D   K   S   T               G   K   P   T   L   Y   N   V   S   L   V 
  AB699686 IGHM*01   F   CH4-CHS gDNA   acc gtg gac aag tcc acc ... ... ... ggt aaa ccc acc ctg tac aac gtc tcc ctg gtc
                                                                                                                       
  U50149   IGHM*02   F   CH4-CHS gDNA   --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                       
  M92050   IGHM*03   F   CH4-CHS cDNA   --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---


                                        ____________________________________
                                        
                                        140 141 142 143 144 145 146 147 148 
                                         L   S   D   T   A   S   T   C   Y  
  AB699686 IGHM*01   F   CH4-CHS gDNA   ctg tcc gac acg gcc agc acc tgc tac 
                                                                            
  U50149   IGHM*02   F   CH4-CHS gDNA   --- --- --- --- --- --- --- --- --- 
                                                                            
  M92050   IGHM*03   F   CH4-CHS cDNA   --- --- --- --- --- --- --- --- --- 


                                   
                                   
                                    1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                    E   G   E   V   S   A   E   E   E   G   F   E   N   L   N   T   M   A   S   T 
  AB699686 IGHM*01   F   M1 gDNA   gag ggg gag gtg agc gct gag gag gaa ggc ttc gag aac ctc aac acc atg gcc tcc acc
                                     
  U50148   IGHM*02   F   M1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39 
                                    F   I   V   L   F   L   L   S   L   F   Y   S   T   T   V   T   L   F   K  
  AB699686 IGHM*01   F   M1 gDNA   ttc atc gtg ctc ttc ctc ctg agc ctc ttc tac agc acc acc gtc acg ctg ttc aag 
                                     
  U50148   IGHM*02   F   M1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                   
                                   
                                    1   2  
                                    V   K  
  AB699686 IGHM*01   F   M2 gDNA   gtg aag 
                                           
  U50148   IGHM*02   F   M2 gDNA   --- --- 

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
17/09/2014
Last updated:
27/05/2016
Authors:
Saida Saljoqi