When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 D   P   A   T   T   P   I   L   F   P   L   S   L   P   C   P 
  X51647   IGHA1*01 F  (CH1)    ... ... ... ... gat ccc gca acc acc ccc atc ctc ttc ccg ctg agc ctc ccc tgt cct
                                                                                                               
  AY386696 IGHA1*02 F           ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 L   S                   G   Q   P   V   V   V   G   C   L   I   Q   G   F   F 
  X51647   IGHA1*01 F  (CH1)    ctc tct ... ... ... ... gga cag ccc gtg gtc gtc ggc tgc ctg atc cag ggc ttc ttc
                                 V                                                                             
  AY386696 IGHA1*02 F           g-g --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P   L       G   P   L   N   V   K   W   T   I   S   G                         
  X51647   IGHA1*01 F  (CH1)    ccc ctg ... ggc cct ctg aat gtg aag tgg acc atc agc ggg ... ... ... ... ... ...
                                                                                                               
  AY386696 IGHA1*02 F           --- --- ... --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     E   N   V   T   F   P   P   V   Q   L   D   T   S                       G 
  X51647   IGHA1*01 F  (CH1)    ... gag aac gtg acc ttc cct cct gtc cag ttg gac acc tca ... ... ... ... ... ggc
                                                                                                               
  AY386696 IGHA1*02 F           ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 L   Y   T   T   S   S   L   L   N   L   T   D   E   E   C                   P 
  X51647   IGHA1*01 F  (CH1)    ctg tac acc acg agt agc cta ctg aac ctg aca gat gaa gag tgt ... ... ... ... cct
                                                                                                               
  AY386696 IGHA1*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 T   C   V   A   C   H   V   E   H   N                   E   V   D   R   Y   L 
  X51647   IGHA1*01 F  (CH1)    aca tgt gtg gcc tgc cac gtg gaa cac aat ... ... ... ... gaa gtg gac aga tat ctg
                                                                                                               
  AY386696 IGHA1*02 F           --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---


                                                                                   
                                120 121 122 123 124 
                                 I   L   P   C   P  
  X51647   IGHA1*01 F  (CH1)    atc ctg ccc tgc cca 
                                                    
  AY386696 IGHA1*02 F           --- --- --- --- --- 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10 
                                 D   T   H   S   S   C   P   P   T   S  
  X51647   IGHA1*01 F  (H)      gat acc cac agc tcc tgc ccc ccc acc tcc 
                                                                        
  AY386696 IGHA1*02 F           --- --- --- --- --- --- --- --- --- --- 

                                                                                                                
                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                         C   G   E   P   S   L   S   L   Q   R   P   D   L   R 
  X51647   IGHA1*01 F  (CH2)    ... ... ... ... ... ... tgc ggg gag ccc agc ctg tcc ctg cag cgg cca gac ctc aga
                                                                                                               
  AY386696 IGHA1*02 F           ... ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   L   L   L           G   S   D   A   S   L   T   C   T   L   R   G   L   K 
  X51647   IGHA1*01 F  (CH2)    gac ctg ctc ctg ... ... ggc tca gac gcc agc ctc acc tgc acc ctg aga ggc ctg aag
                                                                                                               
  AY386696 IGHA1*02 F           --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 D   P       K   D   A   V   F   T   W   E   P   T   N   G   N   E             
  X51647   IGHA1*01 F  (CH2)    gac ccc ... aag gat gcc gtc ttc acc tgg gag ccc aca aac ggg aac gaa ... ... ...
                                                                                                               
  AY386696 IGHA1*02 F           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     P   V   Q   Q   S   P   Q   R   D   P   C   G                             
  X51647   IGHA1*01 F  (CH2)    ... ccg gtc cag cag agc ccc cag cgt gac ccc tgc ggc ... ... ... ... ... ... ...
                                                                                                               
  AY386696 IGHA1*02 F           ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 C   Y   S   V   S   S   V   L   P   G   C   A   E   T   W           T   A   G 
  X51647   IGHA1*01 F  (CH2)    tgc tac agt gtg tcc agt gtg ctg ccc ggc tgt gcg gag acc tgg ... ... act gcg ggg
                                                                                     P               N         
  AY386696 IGHA1*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- c-- --- ... ... -a- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 T   E   F   T   C   T   V   T   H   P   E       I   E   G   S   S   L   T   A 
  X51647   IGHA1*01 F  (CH2)    aca gag ttc acc tgc aca gtc acc cac cct gag ... ata gag ggc agc tcc ctg aca gcc
                                                                                                               
  AY386696 IGHA1*02 F           --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                                        
                                120 121 122 123 124 125 
                                 T   I   R   K   D   T  
  X51647   IGHA1*01 F  (CH2)    acc atc aga aaa gac aca 
                                         S              
  AY386696 IGHA1*02 F           --- --- --c --- --- --- 

                                                                                                                
                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   S   L   T   P   P   Q   V   H   L   L   P   P   P   S   E 
  X51647   IGHA1*01 F  (CH3)    ... ... ... ... ggc agc ctc acc ccg ccc cag gtc cac ctg ctg ccg ccg cca tca gaa
                                                                                                               
  AY386696 IGHA1*02 F           ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   L   A   L           N   A   L   V   T   L   T   C   L   V   R   G   F   S 
  X51647   IGHA1*01 F  (CH3)    gag ctg gcc ctc ... ... aac gcg ctg gtg acg ctg acc tgc ctg gtg agg ggc ttc agc
                                                                                                               
  AY386696 IGHA1*02 F           --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   D   V   L   V   Y   W   T   N   K   G   V   V   V   P   K   D 
  X51647   IGHA1*01 F  (CH3)    ccc ... ... aag gac gtg ctg gtg tac tgg aca aac aaa ggc gtg gtg gtc cca aaa gac
                                                                                                               
  AY386696 IGHA1*02 F           --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --c --- ---


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     S   F   L   V   W   K   P   L   P   E   P   G   Q   E               P   T 
  X51647   IGHA1*01 F  (CH3)    ... agc ttc ctg gtg tgg aag ccc ctg cca gag ccc ggc cag gaa ... ... ... ccc acc
                                                                                                               
  AY386696 IGHA1*02 F           ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   Y   A   V   T   S   L   L   R   V   S   A   E   D   W           N   Q   G 
  X51647   IGHA1*01 F  (CH3)    acc tac gcc gtc acc agc ctg ctg cgc gtg tcg gcc gag gac tgg ... ... aac cag ggg
                                                                                                               
  AY386696 IGHA1*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 D   S   Y   S   C   V   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X51647   IGHA1*01 F  (CH3)    gac agc tac tcc tgc gtg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag
                                                                                                               
  AY386696 IGHA1*02 F           --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                    ______________________________________CHS__                                
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   I   D   R   Q   A               G   K   P   T   H   V   N   V   S   V   V 
  X51647   IGHA1*01 F  (CH3)    acc atc gac cgc caa gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc
                                                                                                               
  AY386696 IGHA1*02 F           --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---


                                ____________________________________                                
                                140 141 142 143 144 145 146 147 148 
                                 V   A   D   V   E   G   V   C   Y  
  X51647   IGHA1*01 F  (CH3)    gtg gca gac gtg gaa ggc gtg tgc tac 
                                                                    
  AY386696 IGHA1*02 F           --- --- --- --- --- --- --- --- --- 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 G   C   Q   E   P   L   P   C   V   V   L   D   L   P   Q   D   S   L   E   E 
  AY386696 IGHA1*02 F  (M)      ggt tgt cag gag ccc ctg ccc tgt gtg gtg ctg gat ctg cca cag gac agc ctg gag gag


                                
                                
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                 E   A   P   S   D   S   L   W   P   T   T   V   T   L   L   T   L   F   L   L 
  AY386696 IGHA1*02 F  (M)      gag gcc cct agc gac agc ctg tgg ccc acc acc gtc acc ctc ctc act ctc ttc ctg ctg


                                
                                
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 S   L   F   Y   S   T   A   L   T   M   T   S   I   R   G   P   P   G   S   K 
  AY386696 IGHA1*02 F  (M)      agc ctg ttc tac agc aca gct ctg acc atg acc agc atc cgg ggc cca cct ggc agc aaa


                                
                                
                                 61  62  63  64  65 
                                 E   G   P   Q   Y  
  AY386696 IGHA1*02 F  (M)      gag gga ccc cag tac