When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 E   A   A   T   N   L   E   L   F   P   M   T   C   P   R   P 
  X82116   IGHA10*01 F  (CH1)   ... ... ... ... gag gct gca acc aat cta gaa ctc ttc ccg atg acc tgc ccc aga cct


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 R   P                   E   Q   T   V   V   V   G   C   L   I   R   G   F   P 
  X82116   IGHA10*01 F  (CH1)   cga cct ... ... ... ... gaa cag acc gtg gtc gtc ggc tgc ctg atc cgg ggc ttc cca


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 L           D   P   L   S   V   S   W   D   V   S   G   E   N   V             
  X82116   IGHA10*01 F  (CH1)   ctg ... ... gac cct ctg agt gtg agc tgg gat gtc agt ggg gag aac gtg ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     R   V   Y   N   F   P   P   A   Q   S   G   T   S                       G 
  X82116   IGHA10*01 F  (CH1)   ... aga gtc tat aac ttc ccg cct gcc cag tct ggc act tca ... ... ... ... ... ggc


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 L   N   T   A   C   S   L   L   S   L   P   S   D   Q   C           P   A   D 
  X82116   IGHA10*01 F  (CH1)   ctg aac act gca tgc agc ctg ctg agc cta cca tct gac cag tgt ... ... cct gca gat


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 D   N   V   T   C   H   V   V   H   N                   N   E   G   Q   D   L 
  X82116   IGHA10*01 F  (CH1)   gac aat gtg acc tgc cac gtg gtg cac aac ... ... ... ... aac gaa ggc cag gat ctc


                                                                                       
                                120 121 122 123 124 125 
                                 P   V   P   C   H   P  
  X82116   IGHA10*01 F  (CH1)   cct gtg ccc tgc cac cca 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15 
                                 E   C   R   E   P   I   I   D   P   T   P   C   P   T   T  
  X82116   IGHA10*01 F  (H)    gag tgc aga gaa ccc att ata gat cca acc ccc tgc ccc acc acc 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                         C   G   E   P   S   L   S   L   Q   R   P   D   I   G 
  X82116   IGHA10*01 F  (CH2)   ... ... ... ... ... ... tgc ggg gag ccc agc ctg tcc ctg cag cgg cca gac atc ggg


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   L   L   L           E   S   K   A   S   L   T   C   T   L   S   G   L   K 
  X82116   IGHA10*01 F  (CH2)   gac ctg ctc ctg ... ... gaa tcg aag gcc agc ctc acc tgc acc ctg agc ggc ctg aag


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 D   P       E   G   A   V   F   T   W   E   P   T   N   G   N   E             
  X82116   IGHA10*01 F  (CH2)   gac ccc ... gag ggc gcc gtc ttc acc tgg gag ccc aca aac ggg aac gaa ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     P   V   Q   Q   S   T   Q   S   Y   P   C   G                             
  X82116   IGHA10*01 F  (CH2)   ... ccc gtc cag cag agc acc cag agt tac ccg tgc ggc ... ... ... ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 C   Y   S   V   S   S   V   L   P   G   C   A   E   P   W           N   A   G 
  X82116   IGHA10*01 F  (CH2)   tgc tac agt gtg tcc agc gtg ctg ccc ggc tgt gcg gag ccc tgg ... ... aac gcg ggg


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 T   E   F   T   C   T   V   T   H   P   E       I   E   G   G   S   L   T   A 
  X82116   IGHA10*01 F  (CH2)   aca gag ttc acc tgc aca gtc acc cac cct gag ... ata gag ggc ggc tcc ctg aca gcc


                                                                               
                                120 121 122 123 
                                 T   I   S   R  
  X82116   IGHA10*01 F  (CH2)   acc atc agc aga 


                                                                                                                                               
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   I   I   I   P   P   L   V   H   L   L   P   P   P   S   D 
  X82116   IGHA10*01 F  (CH3)   ... ... ... ... ggc atc atc atc cca ccc ctg gtc cac ctg ctg ccg ccg cca tca gac


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   L   A   L           N   A   L   V   T   L   T   C   L   V   R   G   F   S 
  X82116   IGHA10*01 F  (CH3)   gaa cta gcc ctg ... ... aac gcg ctg gtg acg ctg acc tgc ctg gtg cgg ggc ttc agc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   D   V   L   V   Y   W   T   N   K   G   V   N   V   P   E   N 
  X82116   IGHA10*01 F  (CH3)   ccc ... ... aag gat gtg ctg gtg tac tgg acg aac aaa ggc gtg aat gtc cct gaa aac


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     S   F   L   L   W   K   P   L   P   E   P   G   Q   E               P   T 
  X82116   IGHA10*01 F  (CH3)   ... agc ttc ctg ctg tgg aag ccc ctg cct gag ccc ggc cag gaa ... ... ... ccc acc


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   Y   A   I   T   S   L   L   R   V   P   A   E   D   W           N   Q   N 
  X82116   IGHA10*01 F  (CH3)   acc tac gcc atc acc agc ctg ctg cgc gtg ccg gcc gag gac tgg ... ... aac cag aat


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   S   Y   T   C   V   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X82116   IGHA10*01 F  (CH3)   gaa agc tac acc tgc gtg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag


                                                                    ______________________________________CHS__                               
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   I   N   R   E   A               G   K   P   T   H   V   N   V   S   V   V 
  X82116   IGHA10*01 F  (CH3)   acc atc aac cgg gag gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc


                                ____________________________________                               
                                140 141 142 143 144 145 146 147 148 
                                 V   A   D   V   E   G   V   C   Y  
  X82116   IGHA10*01 F  (CH3)   gtg gca gac gtg gaa ggc gtg tgc tac