When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 A   S   A   T   T   P   S   L   F   P   L   I   L   P   G   P 
  X82118   IGHA12*01 F  (CH1)   ... ... ... ... gcg tcc gca acc acc ccc agc ctc ttc ccg ctg atc ctc cct gga cct


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 V   S                   G   E   T   V   V   V   G   C   L   I   R   G   F   F 
  X82118   IGHA12*01 F  (CH1)   gtg tcg ... ... ... ... gga gag acc gtg gtc gtc ggc tgc ctg atc cgg ggc ttc ttc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P   L       G   P   L   N   V   S   W   N   G   S   E                         
  X82118   IGHA12*01 F  (CH1)   ccc ctg ... ggc cct ctg aat gtg agc tgg aac ggc agc gag ... ... ... ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     G   D   V   I   F   P   P   V   P   S   P   P   S                       S 
  X82118   IGHA12*01 F  (CH1)   ... ggg gac gtg atc ttc cct cct gtc ccg tct ccc ccc tcg ... ... ... ... ... agc


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 L   Y   T   T   S   S   L   L   N   L   T   I   E   E   C                   P 
  X82118   IGHA12*01 F  (CH1)   ctc tac acc acg agc agc ctg ctg aac ctg aca att gaa gag tgt ... ... ... ... cct


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 K   C   V   I   C   H   V   E   H   N                   E   V   H   R   D   L 
  X82118   IGHA12*01 F  (CH1)   aag tgt gtg atc tgc cac gtg gag cac aat ... ... ... ... gaa gtg cac aga gat ctg


                                                                                    
                                120 121 122 123 124 
                                 I   L   P   C   P  
  X82118   IGHA12*01 F  (CH1)   atc ctg ccc tgc cca 

                                
                                
                                 1   2   3   4   5   6   7   8  
                                 D   C   S   I   P   P   I   T  
  X82118   IGHA12*01 F  (H)     gac tgc tcc atc ccc ccc att acc 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                 D   C   S   I   P   P   I   T                           C   G   E   P   S   L 
  X82118   IGHA12*01 F  (CH2)   gac tgc tcc atc ccc ccc att acc ... ... ... ... ... ... tgc ggg gag ccc agc ctg


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 S   L   Q   R   P   D   I   G   D   L   L   L           E   S   K   A   S   L 
  X82118   IGHA12*01 F  (CH2)   tcc ctg cag cgg cca gac atc ggg gac ctg ctc ctg ... ... gaa tcg aag gcc agc ctc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6

                                 T   C   T   L   S   G   L   K   D   P       E   G   A   V   F   T   W   E   P 
  X82118   IGHA12*01 F  (CH2)   acc tgc acc ctg agc ggc cta aag gac ccc ... gag ggc gcc gtc ttc acc tgg gag ccc


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                 T   N   G   N   E                   P   V   Q   Q   S   V   Q   S   Y   P   C 
  X82118   IGHA12*01 F  (CH2)   aca aac ggg aac gaa ... ... ... ... ccc gtc cag cag agc gtc cag agt tac ccc tgc


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 G                               C   Y   S   V   S   S   V   L   P   G   C   A 
  X82118   IGHA12*01 F  (CH2)   ggc ... ... ... ... ... ... ... tgc tac agt gtg tcc agc gtg ctg ccc ggc tgt gcg


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   P   W           N   A   G   T   E   F   T   C   T   V   T   H   P   E     
  X82118   IGHA12*01 F  (CH2)   gag ccc tgg ... ... aat gcg ggg aca gag ttc acc tgc aca gtc acc cac cct gag ...


                                                                    ____CHS____                               
                                120 121 122 123 124 125 126 127 128 129 130 131 
                                 I   E   G   G   S   L   T   A   K   I   S   R  
  X82118   IGHA12*01 F  (CH2)   ata gag ggc ggc tcc ctg aca gcc aaa atc agc aga 

                                                                                                                                               
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   S   L   T   P   P   Q   V   H   L   L   P   P   P   S   E 
  X82118   IGHA12*01 F  (CH3)   ... ... ... ... ggc agc ctc acg ccg ccc cag gtc cac ctg ctg ccg ccg cca tcg gag


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   L   A   N           N   A   L   V   T   L   T   C   L   G   Q   G   F   S 
  X82118   IGHA12*01 F  (CH3)   gag ctg gcc aac ... ... aac gcg ctg gtg acg ctg acc tgc ctg ggg cag ggc ttc agc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   D   V   L   V   Y   W   T   N   K   G   T   V   V   L   K   E 
  X82118   IGHA12*01 F  (CH3)   ccc ... ... aag gac gtg ctg gtg tac tgg aca aac aaa ggc acg gta gtc ctc aaa gaa


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     S   Y   L   V   W   K   P   L   P   E   P   G   Q   E               P   T 
  X82118   IGHA12*01 F  (CH3)   ... agc tac ctg gta tgg aag ccc ctg cct gag ccc ggc cag gaa ... ... ... ccc acc


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   Y   A   V   T   S   L   L   R   V   P   A   E   D   W           N   Q   N 
  X82118   IGHA12*01 F  (CH3)   acc tat gcc gtc acc agc ctg ctg cgc gtg ccg gcc gag gac tgg ... ... aac cag aat


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   S   Y   T   C   V   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X82118   IGHA12*01 F  (CH3)   gaa agc tac acc tgc gtg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag


                                                                    ______________________________________CHS__                               
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   I   N   R   E   A               G   K   P   T   Q   V   N   V   S   V   V 
  X82118   IGHA12*01 F  (CH3)   acc atc aac cgg gag gcg ... ... ... ggt aaa ccc acc caa gtc aac gtg tct gtg gtc


                                ____________________________________                               
                                140 141 142 143 144 145 146 147 148 
                                 V   A   D   V   E   A   V   C   Y  
  X82118   IGHA12*01 F  (CH3)   gtg gca gat gtg gaa gcc gtg tgc tac