When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12                                                                                                               
  X82119   IGHA13*01 F  (CH1)   ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ...
                                                                                                               
  X00353   IGHA13*02 F          ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ...


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                                     N       S   Q   Y   V   V   V   G   C   L   I   R   G   F 
  X82119   IGHA13*01 F  (CH1)   ... ... ... ... ..g aat ... tca cag tat gtg gtc gtc ggc tgc ctg atc cgg ggc ttc
                                                                                                               
  X00353   IGHA13*02 F          ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ...


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 F   P   P       G   P   L   S       V   S   W   T   V   N   G   E   N   V     
  X82119   IGHA13*01 F  (CH1)   ttc ccc ccg ... ggc cct ctg agt ... gtg agc tgg acc gtc aac ggg gag aat gtg ...
                                                                                                               
  X00353   IGHA13*02 F          ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                             S   A   Y   N   F   P   P   A   Q   S   G   T   S                 
  X82119   IGHA13*01 F  (CH1)   ... ... ... agc gcc tat aac ttc ccg cct gcc cag tct ggc act tca ... ... ... ...
                                                                                                               
  X00353   IGHA13*02 F          ... ... ... ... ... ... ... ... ... ... ... --- --- --- --- --- ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                     G   P   Y   T   A   C   S   E   L   I   L   P   V   T   Q   C           L 
  X82119   IGHA13*01 F  (CH1)   ... ggc ccg tac acc gca tgc agc gag ctg atc cta cca gtt acg cag tgt ... ... ctt
                                                                                                               
  X00353   IGHA13*02 F          ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ---


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 G   Q   K   S   A   A   C   H   V   E   Y   N               S   V   I   N   E 
  X82119   IGHA13*01 F  (CH1)   ggc caa aaa agc gca gcc tgc cac gtg gag tac aac ... ... ... tca gta ata aac gag
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- ---


                                                                                           
                                120 121 122 123 124 125 126 
                                 S   L   P   V   P   F   P  
  X82119   IGHA13*01 F  (CH1)   agt ctg ccc gtg ccc ttc cca 
                                                            
  X00353   IGHA13*02 F          --- --- --- --- --- --- --- 





                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 D   C   C   P   A   N   S   C   C   T   C   P   S   S   S   S   R   N   L   I 
  X82119   IGHA13*01 F  (H)     gac tgc tgc cca gcc aac agc tgc tgc acc tgc ccc agc tcc agc tct aga aac ctc atc
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                
                                
                                 21  22 
                                 S   G  
  X82119   IGHA13*01 F  (H)     tca ggc 
                                        
  X00353   IGHA13*02 F          --- --- 


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                             C   Q   P   S   L   S   L   Q   R   P   D   L   G 
  X82119   IGHA13*01 F  (CH2)   ... ... ... ... ... ... ... tgc cag ccc agc ctg tcc ctg cag cgg cca gac ctc ggg
                                                                                                               
  X00353   IGHA13*02 F          ... ... ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   L   L   L           G   R   D   A   S   L   T   C   T   L   S   G   L   K 
  X82119   IGHA13*01 F  (CH2)   gac ctg ctc ctg ... ... ggc cgg gac gcc agc ctc acc tgc acc ctg agc ggc ctg aag
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 N   P       E   D   A   V   F   T   W   E   P   T   N   G   N   E             
  X82119   IGHA13*01 F  (CH2)   aac ccc ... gag gat gcc gtc ttc act tgg gag ccc aca aac ggc aac gaa ... ... ...
                                                                                                               
  X00353   IGHA13*02 F          --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     P   V   Q   Q   R   A   Q   R   D   L   S   G                             
  X82119   IGHA13*01 F  (CH2)   ... ccc gtc cag cag aga gcc cag cgt gac ctc agt ggc ... ... ... ... ... ... ...
                                                                                                               
  X00353   IGHA13*02 F          ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 C   Y   S   V   S   S   V   L   P   S   S   A   E   T   W           K   A   R 
  X82119   IGHA13*01 F  (CH2)   tgc tac agt gtg tcc agt gtc cta ccc agc agt gcg gag acc tgg ... ... aaa gcg agg
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 T   E   F   T   C   T   V   T   H   P   E       I   D   S   G   S   L   T   A 
  X82119   IGHA13*01 F  (CH2)   aca gag ttc acc tgc aca gtc acc cac cct gag ... ata gac agt ggc tcc cta aca gcc
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                               
                                120 121 122 123 
                                 T   I   S   R  
  X82119   IGHA13*01 F  (CH2)   acc atc agc aga 
                                                
  X00353   IGHA13*02 F          --- --- --- --- 


                                                                                                                                               
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   V   V   T   P   P   Q   V   H   L   L   P   P   P   S   E 
  X82119   IGHA13*01 F  (CH3)   ... ... ... ... ggt gtc gtc acc ccg ccc cag gtc cac ctg ctg ccg ccg ccg tcg gag
                                                                                                               
  X00353   IGHA13*02 F          ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   L   A   L           N   E   Q   V   T   L   T   C   L   V   R   G   F   S 
  X82119   IGHA13*01 F  (CH3)   gag ctg gcc ctg ... ... aat gag cag gtg acg ctg acc tgc ctg gtg cgg ggc ttc agc
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   D   V   L   V   S   W   R   H   Q   G   Q   E   V   P   E   D 
  X82119   IGHA13*01 F  (CH3)   ccg ... ... aag gat gtg ctg gtg tcc tgg agg cac cag ggc cag gag gtc cct gaa gac
                                                                                                               
  X00353   IGHA13*02 F          --c ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     S   F   L   V   W   K   S   M   P   E   S   S   Q   D               K   A 
  X82119   IGHA13*01 F  (CH3)   ... agc ttc ctg gtg tgg aag tcc atg ccc gag tcc agc cag gac ... ... ... aaa gcc
                                                                                                               
  X00353   IGHA13*02 F          ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 

                                 T   Y   A   I   T   S   L   L   R   V   P   A   E   D   W           N   Q   G 
  X82119   IGHA13*01 F  (CH3)   acc tac gcc att acc agc ctg ctg cgc gtg ccg gcc gag gac tgg ... ... aac cag ggg
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 D   T   Y   S   C   M   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X82119   IGHA13*01 F  (CH3)   gac acc tat tcc tgc atg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                    ______________________________________CHS__                               
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  X82119   IGHA13*01 F  (CH3)   acc atc gac cgc ctg gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc
                                                                                                               
  X00353   IGHA13*02 F          --- --- --- --- --t --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---


                                ____________________________________                               
                                140 141 142 143 144 145 146 147 148 
                                 V   A   D   V   E   A   V   C   Y  
  X82119   IGHA13*01 F  (CH3)   gtg gca gac gta gaa gcc gtg tgc tac 
                                                                    
  X00353   IGHA13*02 F          --- --- --- --- --- --- --- --- ---