When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                             D   L   E   N   S   S   P   D   L   I   P   L   P   C   P   I   L 
  X82108   IGHA2*01 F  (CH1)    ... ... ... gat ctc gag aac agc agt cct gac ctc atc ccg cta ccc tgc ccc ata ctt
                                                             T                                                 
  AY386696 IGHA2*02 F           ... ... ... --- --- --- --- -c- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   P                   G   E   P   M   V   I   G   C   L   I   R   G   F   F 
  X82108   IGHA2*01 F  (CH1)    gaa ccc ... ... ... ... gga gag ccc atg gtc atc ggc tgc ctg atc cgg ggc ttc ttc
                                                                                                               
  AY386696 IGHA2*02 F           --- --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P   R       G   P   L   T   V   T   W   N   V   S   G                         
  X82108   IGHA2*01 F  (CH1)    ccc cgg ... ggc cct ctg act gtg aca tgg aac gtc agc ggg ... ... ... ... ... ...
                                                         S                                                     
  AY386696 IGHA2*02 F           --- --- ... --- --- --- -g- --- --- --- --- --- --- --- ... ... ... ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     E   S   V   I   F   P   P   V   P   S   P   P   S                       S 
  X82108   IGHA2*01 F  (CH1)    ... gag agc gtg atc ttc ccg ccc gtc ccg tct ccc ccc tca ... ... ... ... ... agc
                                                                                                               
  AY386696 IGHA2*02 F           ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 L   Y   T   T   Y   S   L   L   R   L   P   A   E   Q   C           P   E   E 
  X82108   IGHA2*01 F  (CH1)    ctc tac acc acg tac agc ctg ctg agg cta cca gct gag cag tgt ... ... cct gaa gaa
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 N   S   V   A   C   R   V   E   H   N                   N   K   G   Q   D   V 
  X82108   IGHA2*01 F  (CH1)    aac agt gtg gcc tgc cgc gtg gag cac aac ... ... ... ... aac aag ggc cag gat gtg
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---


                                                                                        
                                120 121 122 123 124 125 
                                 T   V   P   S   P   P  
  X82108   IGHA2*01 F  (CH1)    acc gtg ccc agc ccc cca 
                                                         
  AY386696 IGHA2*02 F           --- --- --- --- --- --- 


                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 A   C   N   E   S   T   I   E   P   P   T   T   P   T   C   P   C   P   C   P 
  X82108   IGHA2*01 F  (H)      gct tgc aat gag tcc acc ata gaa cca cca acg aca ccc acc tgc ccc tgc ccc tgc ccc
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                
                                
                                 21  22  23 
                                 S   P   S  
  X82108   IGHA2*01 F  (H)      tcc ccc tcc 
                                            
  AY386696 IGHA2*02 F           --- --- --- 


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                         C   G   K   P   S   L   S   L   Q   R   P   D   L   G 
  X82108   IGHA2*01 F  (CH2)    ... ... ... ... ... ... tgt ggg aag ccc agc ctg tcc ctg cag cgg cca gac ctc ggg
                                                                                                               
  AY386696 IGHA2*02 F           ... ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   L   L   L           N   S   N   A   S   L   T   C   T   L   R   G   L   L 
  X82108   IGHA2*01 F  (CH2)    gac ctg ctc ctg ... ... aac tcg aac gcc agc ctc acc tgc acc ctg aga ggc ctg ttg
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 N   P       E   G   A   V   F   T   W   E   P   T   F   G   K   E             
  X82108   IGHA2*01 F  (CH2)    aac ccc ... gag ggc gcc gtc ttc acc tgg gag ccc aca ttt ggg aag gaa ... ... ...
                                                                                                               
  AY386696 IGHA2*02 F           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     P   V   Q   Q   S   P   Q   L   D   H   C   G                             
  X82108   IGHA2*01 F  (CH2)    ... ccc gtc cag cag agt ccc cag ctt gac cac tgt ggc ... ... ... ... ... ... ...
                                                                                                               
  AY386696 IGHA2*02 F           ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 C   Y   S   V   S   S   V   L   P   G   C   A   V   L   W           N   A   G 
  X82108   IGHA2*01 F  (CH2)    tgc tac agt gtg tcc agt gtg ctg cct ggc tgt gca gtg ctc tgg ... ... aat gct ggg
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 T   E   F   T   C   T   V   T   H   P   E       I   E   G   D   S   L   T   G 
  X82108   IGHA2*01 F  (CH2)    aca gag ttc acc tgc aca gtc acc cac cct gag ... ata gag ggc gac tcc cta aca gga
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                                        
                                120 121 122 123 124 125 
                                 T   I   S   K   D   T  
  X82108   IGHA2*01 F  (CH2)    acc att agc aaa gac aca 
                                                        
  AY386696 IGHA2*02 F           --- --- --- --- --- --- 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   S   L   I   P   P   Q   V   H   L   L   P   P   P   S   E 
  X82108   IGHA2*01 F  (CH3)    ... ... ... ... ggc agc ctc atc cca ccc cag gtc cac ctg ctg ccg ccg cca tca gag
                                                                                                               
  AY386696 IGHA2*02 F           ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   L   A   L           N   A   L   V   T   L   T   C   L   V   R   G   F   S 
  X82108   IGHA2*01 F  (CH3)    gag ctg gcc ctc ... ... aac gcg ctg gtg aca ctg acc tgc ctg gtg agg ggc ttc agc
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   D   V   L   V   S   W   T   H   N   G   T   P   V   V   P   K 
  X82108   IGHA2*01 F  (CH3)    ccc ... ... aag gac gtg ctg gtg tcc tgg aca cac aac ggc acc cca gtg gtc ccc aaa
                                                                                                               
  AY386696 IGHA2*02 F           --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                 D   S   Y   L   V   W   K   P   L   R   E   P   G   Q   D               P   T 
  X82108   IGHA2*01 F  (CH3)    gac agc tac ctg gtg tgg aag ccc ctc cgt gag ccc ggc cag gac ... ... ... ccc aca
                                                                     P                                         
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --g -c- --- --- --- --- --- ... ... ... --- ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   Y   A   I   T   S   L   L   R   V   P   A   E   D   W           N   Q   G 
  X82108   IGHA2*01 F  (CH3)    acc tac gcc atc acc agc ctg ctg cgc gtg ccg gcc gag gac tgg ... ... aac cag ggg
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 D   S   Y   S   C   V   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X82108   IGHA2*01 F  (CH3)    gac agc tac tcc tgc gtg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                    ______________________________________CHS__                                
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  X82108   IGHA2*01 F  (CH3)    acc atc gac cgc ctg gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc
                                                                                                               
  AY386696 IGHA2*02 F           --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---


                                ____________________________________                                
                                140 141 142 143 144 145 146 147 148 
                                 V   A   D   V   E   G   V   C   Y  
  X82108   IGHA2*01 F  (CH3)    gtg gca gac gtg gaa ggc gtg tgc tac 
                                                                    
  AY386696 IGHA2*02 F           --- --- --- --- --- --- --- --- --- 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 G   C   Q   E   P   L   P   C   V   V   L   D   L   P   Q   D   S   L   E   E 
  AY386696 IGHA2*02 F  (M)      ggt tgt cag gag ccc ctg ccc tgt gtg gtg ctg gat ctg cca cag gac agc ctg gag gag


                                
                                
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                 E   A   P   G   A   N   L   W   P   T   T   V   T   L   L   T   L   F   L   L 
  AY386696 IGHA2*02 F  (M)      gag gcc ccc ggc gcc aac ctg tgg ccc acc acc gtc acc ctc ctc act ctc ttc ctg ctg


                                
                                
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 S   L   F   Y   S   T   A   L   T   M   T   N   I   R   G   P   A   A   S   K 
  AY386696 IGHA2*02 F  (M)      agc ctg ttc tac agc aca gct ctg acc atg aca aac atc cgg ggc cca gct gcc agc aaa


                                
                                
                                 61  62  63  64  65 
                                 E   G   P   Q   Y  
  AY386696 IGHA2*02 F  (M)      gag gga ccc cag tac